Zhuo Chen

发表

Esculin protects against methionine choline-deficient diet-induced non-alcoholic steatohepatitis by regulating the Sirt1/NF-κB p65 pathway

L. Ye, Jing Chen, Xi-Ding Yang, 2021, Pharmaceutical biology.

Synthesis and structure–activity relationships of pyrazolo‐[3,4‐b]pyridine derivatives as adenosine 5'‐monophosphate‐activated protein kinase activators

Qianbin Li, Gaoyun Hu, Shengjie Sun, 2019, Archiv der Pharmazie.

Discovery of 1-(4-((3-(4-methylpiperazin-1-yl)propyl)amino)benzyl)-5-(trifluoromethyl)pyridin-2(1H)-one, an orally active multi-target agent for the treatment of diabetic nephropathy.

L. Tao, Qianbin Li, Dejian Jiang, 2018, Bioorganic & medicinal chemistry letters.

Identification of selective homeodomain interacting protein kinase 2 inhibitors, a potential treatment for renal fibrosis.

L. Tao, Qianbin Li, Zhang-zhe Peng, 2022, Bioorganic chemistry.

Binding pocket-based design, synthesis and biological evaluation of novel selective BRD4-BD1 inhibitors.

Qianbin Li, Gaoyun Hu, Zutao Yu, 2019, Bioorganic & medicinal chemistry.

Targeted degradation of CD147 proteins in melanoma.

Zhe Zhou, Qianbin Li, Gaoyun Hu, 2020, Bioorganic chemistry (Print).

Soluble guanylate cyclase stimulators and activators: Where are we, where to go?

Jingqing Yang, Qianbin Li, Gaoyun Hu, 2019, Mini reviews in medicinal chemistry.

Piperazine ferulate attenuates high glucose-induced mesangial cell injury via the regulation of p66Shc

Xi-Ding Yang, D. Xiang, Yong-Yu Yang, 2021, Molecular medicine reports.

Novel pyrazolo[3,4‐b]pyridine derivatives: Synthesis, structure–activity relationship studies, and regulation of the AMPK/70S6K pathway

Qianbin Li, Dejian Jiang, Gaoyun Hu, 2022, Archiv der Pharmazie.

Dual inhibitors of ASK1 and PDK1 kinases: Design, synthesis, molecular docking and mechanism studies of N-benzyl pyridine-2-one containing derivatives as anti-fibrotic agents.

Qianbin Li, Gaoyun Hu, Yuanyuan Cao, 2022, European journal of medicinal chemistry.

Synthesis and structure-activity relationship of 5-substituent-2(1H)-pyridone derivatives as anti-fibrosis agents.

B. Liu, L. Tao, G. Hu, 2012, Bioorganic & medicinal chemistry letters.

Synthesis and vasodilator effects of rutaecarpine analogues which might be involved transient receptor potential vanilloid subfamily, member 1 (TRPV1).

Gaoyun Hu, Y. Xie, Yuan‐jian Li, 2009, Bioorganic & medicinal chemistry.

Discovery of Novel Pyrazolo[3,4-b] pyridine Derivatives with Dual Activities of Vascular Remodeling Inhibition and Vasodilation for the Treatment of Pulmonary Arterial Hypertension.

Qinglian Liu, Lijun Li, Qianbin Li, 2020, Journal of medicinal chemistry.

Synthesis, anti-lung cancer activity and molecular docking study of 3-methylene-2-oxoindoline-5-carboxamide derivatives

Qianbin Li, Gaoyun Hu, Meng Lv, 2017, Medicinal Chemistry Research.

Drug repurposing and rediscovery: Design, synthesis and preliminary biological evaluation of 1-arylamino-3-aryloxypropan-2-ols as anti-melanoma agents.

Qianbin Li, Gaoyun Hu, Zhuo Chen, 2020, Bioorganic & medicinal chemistry.

Cost-effectiveness Analysis of Pembrolizumab Plus Axitinib Versus Sunitinib in First-line Advanced Renal Cell Carcinoma in China

Gaoyun Hu, Chongqing Tan, X. Wan, 2019, Clinical Drug Investigation.

Multistep Virtual Screening Based Identification of Homeodomain-Interacting Protein Kinase 2 Inhibitors: An Opportunity for Treating Chronic Kidney Disease

Qianbin Li, Gaoyun Hu, Yuanyuan Cao, 2021, Chemometrics and Intelligent Laboratory Systems.

Piperazine ferulate prevents high-glucose-induced filtration barrier injury of glomerular endothelial cells

Dang Xiang, Xi-Ding Yang, Yong-Yu Yang, 2021, Experimental and therapeutic medicine.

Therapeutic strategies of diabetic nephropathy: recent progress and future perspectives.

Qianbin Li, Gaoyun Hu, Meng Lv, 2015, Drug discovery today.

Synthesis, Pharmacophores, and Mechanism Study of Pyridin‐2(1H)‐one Derivatives as Regulators of Translation Initiation Factor 3A

Qianbin Li, Gaoyun Hu, Zhaoqian Liu, 2013, Archiv der Pharmazie.

An emerging strategy for targeted therapy of pulmonary arterial hypertension: vasodilation plus vascular remodeling inhibition.

Qianbin Li, Gaoyun Hu, Zhuo Chen, 2022, Drug discovery today.

Pulmonary artery smooth muscle cell phenotypic switching: A key event in the early stage of pulmonary artery hypertension.

Qianbin Li, Gaoyun Hu, Yuanyuan Cao, 2023, Drug discovery today.

Recent advances in the development of HIPK2 inhibitors as anti-renal fibrosis agents.

Qianbin Li, Gaoyun Hu, Zhuo Chen, 2023, Future medicinal chemistry.

Fluorofenidone attenuates paraquat-induced pulmonary fibrosis by regulating the PI3K/Akt/mTOR signaling pathway and autophagy

Zhuo Chen, T. Wang, Sha Li, 2021, Molecular medicine reports.

Discovery of Ureido-Based Apcin Analogues as Cdc20-specific Inhibitors against Cancer

Qianbin Li, Gaoyun Hu, Yiqin He, 2023, Pharmaceuticals.

Metabolic profiles of neratinib in rat by using ultra-high-performance liquid chromatography coupled with diode array detector and Q-Exactive Orbitrap tandem mass spectrometry.

Zhuo Chen, Sha Li, Yangke Wu, 2018, Biomedical chromatography : BMC.

A Novel PDK1/MEK Dual Inhibitor Induces Cytoprotective Autophagy via the PDK1/Akt Signaling Pathway in Non-Small Cell Lung Cancer

Qianbin Li, Gaoyun Hu, Zutao Yu, 2023, Pharmaceuticals.

A novel dual MEK/PDK1 inhibitor 9za retards the cell cycle at G0/G1 phase and induces mitochondrial apoptosis in non-small cell lung cancer cells

Fengying Huang, Qianbin Li, Gaoyun Hu, 2020, PeerJ.

Dual inhibitors of RAF-MEK-ERK and PI3K-PDK1-AKT pathways: Design, synthesis and preliminary anticancer activity studies of 3-substituted-5-(phenylamino) indolone derivatives.

Xiaoping Yang, Qianbin Li, Gaoyun Hu, 2019, Bioorganic & medicinal chemistry.

Effect of Fluorofenidone Against Paraquat-Induced Pulmonary Fibrosis Based on Metabolomics and Network Pharmacology

Zhuo Chen, T. Wang, Sha Li, 2021, Medical science monitor : international medical journal of experimental and clinical research.

Discovery of a Dual Tubulin Polymerization and Cell Division Cycle 20 Homologue Inhibitor via Structural Modification on Apcin.

Qianbin Li, Gaoyun Hu, F. Huang, 2020, Journal of medicinal chemistry.

9za plays cytotoxic and proapoptotic roles and induces cytoprotective autophagy through the PDK1/Akt/mTOR axis in non‐small‐cell lung cancer

Fengying Huang, Gaoyun Hu, Zhaoqian Liu, 2019, Journal of cellular physiology.

Discovery of 1-(4-((3-(4-methylpiperazin-1-yl)propyl)amino)benzyl)-5-(trifluoromethyl)pyridin-2(1H)-one, an orally active multi-target agent for the treatment of diabetic nephropathy.

L. Tao, Qianbin Li, Dejian Jiang, 2018, Bioorganic & medicinal chemistry letters.

Inhibitors of 11β-Hydroxylase (CYP11B1) for Treating Diseases Related to Excess Cortisol.

Qianbin Li, Gaoyun Hu, Guishan Tan, 2016, Current medicinal chemistry.

Soluble Guanylate Cyclase: A New Therapeutic Target for Fibrotic Diseases.

R. Yi, Qianbin Li, Gaoyun Hu, 2017, Current medicinal chemistry.