Arielle Shkedi

KRASG12C inhibition produces a driver-limited state revealing collateral dependencies

Alex Y. Ge, Luke A. Gilbert, K. Shokat, 2019, Science Signaling.

A campaign targeting a conserved Hsp70 binding site uncovers how subcellular localization is linked to distinct biological activities.

Luke A. Gilbert, J. Weissman, J. Frydman, 2022, Cell chemical biology.

The interactions of molecular chaperones with client proteins: why are they so weak?

J. Gestwicki, Cory M. Nadel, Taylor Arhar, 2021, The Journal of biological chemistry.

Selective vulnerabilities in the proteostasis network of castration-resistant prostate cancer.

L. Neckers, R. Karnes, J. Gestwicki, 2022, Cell chemical biology.

Inhibitor Combinations Reveal Wiring of the Proteostasis Network in Prostate Cancer Cells.

L. Neckers, J. Gestwicki, W. Eckalbar, 2021, Journal of medicinal chemistry.