A. Gavai

发表

Design and synthesis of 4-[3,5-dioxo-11-oxa-4,9-diazatricyclo[5.3.1.0(2,6)]undec-4-yl]-2-trifluoromethyl-benzonitriles as androgen receptor antagonists.

J. Chen, L. Schweizer, M. Salvati, 2010, Bioorganic & medicinal chemistry letters.

Beta 3 agonists. Part 1: evolution from inception to BMS-194449.

R. Gregg, A. Mathur, T. Waldron, 2001, Bioorganic & medicinal chemistry letters.

BMS-196085: a potent and selective full agonist of the human beta(3) adrenergic receptor.

A. Mathur, T. Waldron, K. Dickinson, 2001, Bioorganic & medicinal chemistry letters.

Novel cytokine release inhibitors. Part III: Truncated analogs of tripterine.

A. Zilberstein, F. Huang, W. Chan, 1998, Bioorganic & medicinal chemistry letters.

Overview: Recent Developments in Sulphidopeptide Leukotriene Receptor Antagonists

R. Galemmo, F. Huang, A. Gavai, 1992 .

Discovery of novel 1-arylmethyl pyrrolidin-2-yl ethanol amines as calcium-sensing receptor antagonists.

J. Y. Roberge, Roy J. Vaz, R. Seethala, 2005, Bioorganic & medicinal chemistry letters.

Development of BET Inhibitors as Potential Treatments for Cancer: Optimization of Pharmacokinetic Properties

M. D. Hill, Derek J. Norris, J. Tokarski, 2022, ACS Medicinal Chemistry Letters.

Development of BET inhibitors as potential treatments for cancer: A search for structural diversity.

M. D. Hill, J. Tokarski, S. Sheriff, 2021, Bioorganic & medicinal chemistry letters.

Discovery and Preclinical Pharmacology of an Oral Bromodomain and Extra-Terminal (BET) Inhibitor Using Scaffold-Hopping and Structure-Guided Drug Design.

Vijay T. Ahuja, Derek J. Norris, J. Tokarski, 2021, Journal of medicinal chemistry.

Development of BET inhibitors as potential treatments for cancer: A new carboline chemotype.

M. D. Hill, J. Tokarski, S. Sheriff, 2021, Bioorganic & medicinal chemistry letters.

Simple analogs of ginkgolide b which are highly active antagonists of platelet activating factor

E. Corey, A. Gavai, 1989 .

Novel pyrrolo[2,1-f][1,2,4]triazin-4-amines: Dual inhibitors of EGFR and HER2 protein tyrosine kinases.

Ping Chen, Derek J. Norris, J. Tokarski, 2011, Bioorganic & medicinal chemistry letters.

New C-5 substituted pyrrolotriazine dual inhibitors of EGFR and HER2 protein tyrosine kinases.

Henry Wong, Punit Marathe, John S Tokarski, 2007, Bioorganic & medicinal chemistry letters.

Pyrrolotriazine-5-carboxylate ester inhibitors of EGFR and HER2 protein tyrosine kinases and a novel one-pot synthesis of C-4 subsitituted pyrrole-2,3-dicarboxylate diesters

James G. Tarrant, B. Fink, T. Wong, 2006 .

Discovery of Pyridazinone and Pyrazolo[1,5-a]pyridine Inhibitors of C-Terminal Src Kinase.

Vijay T. Ahuja, J. Tokarski, D. Xie, 2019, ACS medicinal chemistry letters.

Enantioselective route to a key intermediate in the total synthesis of ginkgolide B

E. Corey, A. Gavai, 1988 .

Discovery and preclinical evaluation of [4-[[1-(3-fluorophenyl)methyl]-1H-indazol-5-ylamino]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]carbamic acid, (3S)-3-morpholinylmethyl ester (BMS-599626), a selective and orally efficacious inhibitor of human epidermal growth factor receptor 1 and 2 kinases.

J. Fargnoli, Derek J. Norris, J. Tokarski, 2009, Journal of medicinal chemistry.

Stereospecific deconjugation of alkyl (E)- and (Z)-3-trimethylstannyl-2-alkenoates

E. Piers, A. Gavai, 1990 .

A (Z)-ethylidenecyclopentane annulation method. Total syntheses of (.+-.)-anhydrooplopanone, (.+-.)-oplopanone, and (.+-.)-8-epi-oplopanone

E. Piers, A. Gavai, 1990 .

Stereospecific protonative deconjugation of alkyl 3-trimethylstannylalk-2-enoates

E. Piers, A. Gavai, 1985 .

BMS-871: a novel orally active pan-Notch inhibitor as an anticancer agent.

Derek J. Norris, D. Shen, G. Trainor, 2015, Bioorganic & medicinal chemistry letters.

Crystallization-Induced Dynamic Resolution toward the Synthesis of (S)-7-Amino-5H,7H-dibenzo[b,d]-azepin-6-one: An Important Scaffold for γ-Secretase Inhibitors

A. Mathur, Anuradha Gupta, Richard Rampulla, 2016 .

Identification of a novel series of tetrahydrodibenzazocines as inhibitors of 17beta-hydroxysteroid dehydrogenase type 3.

Derek J. Norris, J. Tokarski, S. D. Kimball, 2006, Bioorganic & medicinal chemistry letters.

Antitumor and Antiangiogenic Activities of BMS-690514, an Inhibitor of Human EGF and VEGF Receptor Kinase Families

J. Fargnoli, Derek J. Norris, J. Hunt, 2011, Clinical Cancer Research.

Preclinical Antitumor Activity of BMS-599626, a pan-HER Kinase Inhibitor That Inhibits HER1/HER2 Homodimer and Heterodimer Signaling

J. Hunt, F. Lee, B. Fink, 2006, Clinical Cancer Research.

[2.2.1]-Bicyclic sultams as potent androgen receptor antagonists.

Michael A. Galella, G. Trainor, Weifang Shan, 2016, Bioorganic & medicinal chemistry letters.

Novel cytokine release inhibitors. Part IV: analogs of podocarpic acid.

A. Zilberstein, J. Regan, S. Djurić, 1999, Bioorganic & medicinal chemistry letters.

Initial results from a phase I/IIa trial evaluating BMS-986158, an inhibitor of the bromodomain and extra-terminal (BET) proteins, in patients (pts) with advanced cancer.

D. Jackson, S. Chasalow, J. Diamond, 2018, Annals of oncology : official journal of the European Society for Medical Oncology.

Discovery of Clinical Candidate BMS-906024: A Potent Pan-Notch Inhibitor for the Treatment of Leukemia and Solid Tumors.

Derek J. Norris, D. Shen, G. Trainor, 2015, ACS medicinal chemistry letters.

Preclinical pharmacokinetics and in vitro metabolism of BMS-690514, a potent inhibitor of EGFR and VEGFR2.

P. Marathe, T. Wong, Hongjiang Zhang, 2010, Journal of pharmaceutical sciences.

Novel C-5 aminomethyl pyrrolotriazine dual inhibitors of EGFR and HER2 protein tyrosine kinases.

Henry Wong, Punit Marathe, John S Tokarski, 2007, Bioorganic & medicinal chemistry letters.

5-((4-Aminopiperidin-1-yl)methyl)pyrrolotriazine dual inhibitors of EGFR and HER2 protein tyrosine kinases.

Henry Wong, Punit Marathe, John S Tokarski, 2007, Bioorganic & medicinal chemistry letters.

BMS-201620: a selective beta 3 agonist.

T. Waldron, K. Dickinson, R. George, 2004, Bioorganic & medicinal chemistry letters.

Convenient (Z)-ethylidenecyclopentane annulation sequences. Total synthesis of (±)-oplopanone, (±)-8-epi-oplopanone, and (±)-anhydro-oplopanone

A. Gavai, E. Piers*, 1986 .

Identification and Optimization of Small Molecule Pyrazolopyrimidine TLR7 Agonists for Applications in Immuno-oncology.

Murugaiah A. M. Subbaiah, G. Schieven, A. Mathur, 2024, ACS medicinal chemistry letters.

Discovery of Novel TLR7 Agonists as Systemic Agent for Combination With aPD1 for Use in Immuno-oncology.

G. Schieven, A. Mathur, D. Critton, 2024, ACS medicinal chemistry letters.