Hyunbum Jang

发表

Review: Precision medicine and driver mutations: Computational methods, functional assays and conformational principles for interpreting cancer drivers

Ruth Nussinov, Feixiong Cheng, Hyunbum Jang, 2019, PLoS Comput. Biol..

Precision medicine review: rare driver mutations and their biophysical classification

Ruth Nussinov, Feixiong Cheng, Hyunbum Jang, 2019, Biophysical Reviews.

Protein ensembles link genotype to phenotype

Ruth Nussinov, Hyunbum Jang, Chung-Jung Tsai, 2019, PLoS Comput. Biol..

Computational Structural Biology: Successes, Future Directions, and Challenges

Ruth Nussinov, Amarda Shehu, Hyunbum Jang, 2019, Molecules.

Allostery in Its Many Disguises: From Theory to Applications.

Ruth Nussinov, Ivet Bahar, Dima Kozakov, 2019, Structure.

GTP-dependent K-Ras dimerization

Ozlem Keskin, Ruth Nussinov, Hyunbum Jang, 2015 .

K-Ras4B/calmodulin/PI3Kα: A promising new adenocarcinoma-specific drug target?

Ozlem Keskin, Ruth Nussinov, Hyunbum Jang, 2016, Expert opinion on therapeutic targets.

GTP-Dependent K-Ras Dimerization.

Ozlem Keskin, Ruth Nussinov, Hyunbum Jang, 2015, Structure.

Plasma membrane regulates Ras signaling networks

Ozlem Keskin, Ruth Nussinov, Hyunbum Jang, 2015, Cellular logistics.

Ras Conformational Ensembles, Allostery, and Signaling.

Ozlem Keskin, Ruth Nussinov, Shaoyong Lu, 2016, Chemical reviews.

Truncated β-amyloid peptide channels provide an alternative mechanism for Alzheimer’s Disease and Down syndrome

Ruth Nussinov, Hyunbum Jang, Ratnesh Lal, 2010, Proceedings of the National Academy of Sciences.

Oncogenic KRas mobility in the membrane and signaling response.

Ruth Nussinov, Hyunbum Jang, Chung-Jung Tsai, 2019, Seminars in cancer biology.

Calmodulin and PI3K Signaling in KRAS Cancers.

Ruth Nussinov, Shaoyong Lu, Jian Zhang, 2017, Trends in cancer.

Oncogenic KRAS signaling and YAP1/β-catenin: Similar cell cycle control in tumor initiation.

Ruth Nussinov, Tamás Korcsmáros, Peter Csermely, 2016, Seminars in cell & developmental biology.

RASSF5: An MST activator and tumor suppressor in vivo but opposite in vitro.

Ruth Nussinov, Hyunbum Jang, Chung-Jung Tsai, 2016, Current opinion in structural biology.

Antimicrobial protegrin-1 forms amyloid-like fibrils with rapid kinetics suggesting a functional link.

Ruth Nussinov, Hyunbum Jang, Ratnesh Lal, 2011, Biophysical journal.

The disordered hypervariable region and the folded catalytic domain of oncogenic K-Ras4B partner in phospholipid binding.

Ruth Nussinov, Hyunbum Jang, Avik Banerjee, 2016, Current opinion in structural biology.

Is Nanoclustering essential for all oncogenic KRas pathways? Can it explain why wild-type KRas can inhibit its oncogenic variant?

Ruth Nussinov, Hyunbum Jang, Chung-Jung Tsai, 2019, Seminars in cancer biology.

GTP Binding and Oncogenic Mutations May Attenuate Hypervariable Region (HVR)-Catalytic Domain Interactions in Small GTPase K-Ras4B, Exposing the Effector Binding Site*

Ruth Nussinov, Shaoyong Lu, Hyunbum Jang, 2015, The Journal of Biological Chemistry.

The Structural Basis of Oncogenic Mutations G12, G13 and Q61 in Small GTPase K-Ras4B

Ruth Nussinov, Shaoyong Lu, Hyunbum Jang, 2016, Scientific Reports.

High-Affinity Interaction of the K-Ras4B Hypervariable Region with the Ras Active Site

Ruth Nussinov, Hyunbum Jang, Avik Banerjee, 2015, Biophysical journal.

Unraveling the molecular mechanism of interactions of the Rho GTPases Cdc42 and Rac1 with the scaffolding protein IQGAP2

Ozlem Keskin, Ruth Nussinov, Hyunbum Jang, 2018, The Journal of Biological Chemistry.

Principles of K-Ras effector organization and the role of oncogenic K-Ras in cancer initiation through G1 cell cycle deregulation

Ozlem Keskin, Ruth Nussinov, Hyunbum Jang, 2015, Expert review of proteomics.

Intrinsic protein disorder in oncogenic KRAS signaling

Ruth Nussinov, Jian Zhang, Hyunbum Jang, 2017, Cellular and Molecular Life Sciences.

Probing ion channel activity of human islet amyloid polypeptide (amylin).

Ruth Nussinov, Hyunbum Jang, Guanghong Wei, 2012, Biochimica et biophysica acta.

The Key Role of Calmodulin in KRAS-Driven Adenocarcinomas

Ozlem Keskin, Ruth Nussinov, Hyunbum Jang, 2015, Molecular Cancer Research.

Raf-1 Cysteine-Rich Domain Increases the Affinity of K-Ras/Raf at the Membrane, Promoting MAPK Signaling.

Ruth Nussinov, Jian Zhang, Hyunbum Jang, 2018, Structure.

Membrane-associated Ras dimers are isoform-specific: K-Ras dimers differ from H-Ras dimers.

Ozlem Keskin, Ruth Nussinov, Hyunbum Jang, 2016, The Biochemical journal.

Independent and core pathways in oncogenic KRAS signaling

Ruth Nussinov, Hyunbum Jang, Chung-Jung Tsai, 2016, Expert review of proteomics.

A New View of Ras Isoforms in Cancers.

Ruth Nussinov, Hyunbum Jang, Chung-Jung Tsai, 2016, Cancer research.

Models of beta-amyloid ion channels in the membrane suggest that channel formation in the bilayer is a dynamic process.

Ruth Nussinov, Hyunbum Jang, R. Nussinov, 2007, Biophysical journal.

Autoinhibition in Ras effectors Raf, PI3Kα, and RASSF5: a comprehensive review underscoring the challenges in pharmacological intervention

Ruth Nussinov, Hyunbum Jang, Chung-Jung Tsai, 2018, Biophysical Reviews.

The higher level of complexity of K‐Ras4B activation at the membrane

Ruth Nussinov, Shaoyong Lu, Jian Zhang, 2016, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Inhibitors of Ras–SOS Interactions

Ruth Nussinov, Shaoyong Lu, Jian Zhang, 2016, ChemMedChem.

Atomic force microscopy and MD simulations reveal pore-like structures of all-D-enantiomer of Alzheimer's β-amyloid peptide: relevance to the ion channel mechanism of AD pathology.

Ruth Nussinov, Hyunbum Jang, Ratnesh Lal, 2012, The journal of physical chemistry. B.

A New View of Pathway-Driven Drug Resistance in Tumor Proliferation.

Ruth Nussinov, Hyunbum Jang, Chung-Jung Tsai, 2017, Trends in pharmacological sciences.

β-Barrel topology of Alzheimer's β-amyloid ion channels.

Ruth Nussinov, Hyunbum Jang, Ratnesh Lal, 2010, Journal of molecular biology.

Oncogenic Ras Isoforms Signaling Specificity at the Membrane.

Ruth Nussinov, Hyunbum Jang, Chung-Jung Tsai, 2017, Cancer research.

Drugging Ras GTPase: a comprehensive mechanistic and signaling structural view.

Ruth Nussinov, Shaoyong Lu, Jian Zhang, 2016, Chemical Society reviews.