W. Zhong

发表

Fragment based drug discovery: practical implementation based on ¹⁹F NMR spectroscopy.

L. Poppe, J. B. Jordan, P. Schnier, 2012, Journal of medicinal chemistry.

Development of 2-aminooxazoline 3-azaxanthenes as orally efficacious β-secretase inhibitors for the potential treatment of Alzheimer's disease.

S. Hitchcock, A. Cheng, Yuan Cheng, 2015, Bioorganic & medicinal chemistry letters.

GPCR structure and function relationship: identification of a biased apelin receptor mutant.

Liaoyuan A. Hu, Yingli Ma, Yaping Sun, 2018, The Biochemical journal.

Synthesis and conformational analysis of a,a-difluoroalkyl heteroaryl ethers

S. Hitchcock, H. Monenschein, Daniel B Horne, 2009 .

Structural insights into ligand recognition and selectivity of somatostatin receptors

Liaoyuan A. Hu, Yingli Ma, Qiang Zhao, 2022, Cell Research.

Structure-guided discovery of a single-domain antibody agonist against human apelin receptor

Liaoyuan A. Hu, Yingli Ma, Yaping Sun, 2020, Science Advances.

Design and Enabling Development of Hydroxyethylamine-Derived BACE1 Inhibitor

J. Tedrow, W. Zhong, 2016 .

Cryo-EM structures of PAC1 receptor reveal ligand binding mechanism

Liaoyuan A. Hu, Yingli Ma, Hongwei Wang, 2020, Cell Research.

Convenient Synthesis of Novel Nitrones: (Z)-4-Amino-5-hydroxyimino-2,5-dihydro-1H-imidazole 3-Oxides

Zhanxiong Li, Lihua Qiu, Guo-qiang Chen, 2009 .

Design and synthesis of quinolin-2(1H)-one derivatives as potent CDK5 inhibitors.

Jiandong Zhang, T. Osslund, C. Henley, 2007, Bioorganic & medicinal chemistry letters.

Inverse-Electron-Demand Diels-Alder Reactions for the Synthesis of Pyridazines on DNA.

Xiaojie Lu, Wenge Zhong, Wenting Wu, 2018, Organic letters.

Total synthesis of fostriecin (CI-920).

D. Boger, S. Ichikawa, W. Zhong, 2001, Journal of the American Chemical Society.

Design and preparation of a potent series of hydroxyethylamine containing β-secretase inhibitors that demonstrate robust reduction of central β-amyloid.

Yuan Cheng, Wenge Zhong, Michael D Bartberger, 2012, Journal of medicinal chemistry.

Palladium-Promoted DNA-Compatible Heck Reaction.

Xiaojie Lu, Wenge Zhong, Jiaxiang Liu, 2019, Organic letters.

Preclinical Evaluation of AMG 337, a Highly Selective Small Molecule MET Inhibitor, in Hepatocellular Carcinoma

Liaoyuan A. Hu, O. Wang, K. Rex, 2015, Molecular Cancer Therapeutics.

Structural Basis for Apelin Control of the Human Apelin Receptor.

Liaoyuan A. Hu, R. Stevens, Fei Xu, 2017, Structure.

Hydroxyethylamine-based inhibitors of BACE1: P₁-P₃ macrocyclization can improve potency, selectivity, and cell activity.

R. Wahl, S. Hitchcock, M. Citron, 2013, Bioorganic & medicinal chemistry letters.

Structure guided P1' modifications of HEA derived β-secretase inhibitors for the treatment of Alzheimer's disease.

S. Hitchcock, H. Monenschein, M. Bartberger, 2012, Bioorganic & medicinal chemistry letters.

A Potent and Orally Efficacious, Hydroxyethylamine-Based Inhibitor of β-Secretase.

Yuan Cheng, Yi Luo, Wenge Zhong, 2012, ACS medicinal chemistry letters.

Design and synthesis of potent, orally efficacious hydroxyethylamine derived β-site amyloid precursor protein cleaving enzyme (BACE1) inhibitors.

R. Wahl, S. Hitchcock, Yuan Cheng, 2012, Journal of medicinal chemistry.

Discovery of TRPM8 Antagonist ( S)-6-(((3-Fluoro-4-(trifluoromethoxy)phenyl)(3-fluoropyridin-2-yl)methyl)carbamoyl)nicotinic Acid (AMG 333), a Clinical Candidate for the Treatment of Migraine.

H. Monenschein, M. Horner, M. Bartberger, 2018, Journal of medicinal chemistry.

Design and synthesis of 6-oxo-1,6-dihydropyridines as CDK5 inhibitors.

C. Henley, D. Powers, R. Rzasa, 2009, Bioorganic & medicinal chemistry letters.

Structure-activity relationships of 3,4-dihydro-1H-quinazolin-2-one derivatives as potential CDK5 inhibitors.

V. Viswanadhan, T. Osslund, D. Powers, 2007, Bioorganic & medicinal chemistry.

Cryo-EM structures of PAC1 receptor reveal ligand binding mechanism

Liaoyuan A. Hu, Yingli Ma, Hongwei Wang, 2020, Cell Research.

Discovery of selective biaryl ethers as PDE10A inhibitors: improvement in potency and mitigation of Pgp-mediated efflux.

E. Hu, Shannon Rumfelt, N. Chen, 2012, Bioorganic & medicinal chemistry letters.

Establishing the Relationship between In Vitro Potency, Pharmacokinetic, and Pharmacodynamic Parameters in a Series of Orally Available, Hydroxyethylamine-Derived β-Secretase Inhibitors

S. Hitchcock, M. Citron, S. Babu-Khan, 2012, Journal of Pharmacology and Experimental Therapeutics.

Stereoselective synthesis of anti-N-protected 3-amino-1,2-epoxides by nucleophilic addition to N-tert-butanesulfinyl imine of a glyceraldehyde synthon.

R. Hungate, P. Reider, Patricia Lopez, 2009, Journal of Organic Chemistry.

Direct Construction of Chiral Ether via Highly Efficient Heck Reaction and N-Directed Asymmetric Hydrogenation for Large-Scale Synthesis of MALT1 Inhibitor RGT-068A

Xudong Wei, Xingao Peng, W. Zhong, 2022, Organic Process Research & Development.

Accelerated Discovery of Macrocyclic CDK2 Inhibitor QR-6401 by Generative Models and Structure-Based Drug Design.

L. Yao, Tingyang Xu, Wei Huang, 2023, ACS medicinal chemistry letters.

Fragment-Based Computational Method for Designing GPCR Ligands

Qing Zhang, Xun Li, Yan Li, 2020, J. Chem. Inf. Model..

Ruthenium-Promoted C-H Activation Reactions between DNA-Conjugated Acrylamide and Aromatic Acids.

Xiaojie Lu, Wenge Zhong, Jiaxiang Liu, 2018, Organic letters.