Victor R. Guarino

发表

Snowmass 2021 CMB-S4 White Paper

Adrian T. Lee, Edward J. Wollack, Jae Hwan Kang, 2022, 2203.08024.

The Molecular Design of Prodrugs by Functional Group

Victor R. Guarino, 2011 .

Biologic-like In Vivo Efficacy with Small Molecule Inhibitors of TNFα Identified Using Scaffold Hopping and Structure-Based Drug Design Approaches.

D. Shuster, J. Macor, J. Yanchunas, 2020, Journal of medicinal chemistry.

Azaxanthene based selective glucocorticoid receptor modulators: design, synthesis, and pharmacological evaluation of (S)-4-(5-(1-((1,3,4-thiadiazol-2-yl)amino)-2-methyl-1-oxopropan-2-yl)-5H-chromeno[2,3-b]pyridin-2-yl)-2-fluoro-N,N-dimethylbenzamide (BMS-776532) and its methylene homologue (BMS-7918

A. Doweyko, D. Shuster, J. Barrish, 2011, Journal of medicinal chemistry.

Discovery of an Oxycyclohexyl Acid Lysophosphatidic Acid Receptor 1 (LPA1) Antagonist BMS-986278 for the Treatment of Pulmonary Fibrotic Diseases.

C. Chu, S. Jusuf, Yanou Yang, 2021, Journal of medicinal chemistry.

Modulating Solubility Through Prodrugs for Oral and IV Drug Delivery

Victor R. Guarino, 2011 .

Discovery of a Phenylpyrazole Amide ROCK Inhibitor as a Tool Molecule for in vivo Studies.

David S. Taylor, J. Sack, Chunhong Yan, 2020, Bioorganic & medicinal chemistry letters.

Sulfenamides as prodrugs of NH-acidic compounds: a new prodrug option for the amide bond.

V. Stella, V. Karunaratne, Victor R. Guarino, 2007, Bioorganic & medicinal chemistry letters.

Discovery of Two Novel Antiplatelet Clinical Candidates (BMS-986120 and BMS-986141) That Antagonize Protease-Activated Receptor 4.

Shana L. Posy, A. Mathur, J. Guay, 2022, Journal of medicinal chemistry.

Discovery of Potent Protease-Activated Receptor 4 Antagonists with in vivo Antithrombotic Efficacy.

Shana L. Posy, D. Seiffert, Yanou Yang, 2019, Journal of medicinal chemistry.

BMS-871: a novel orally active pan-Notch inhibitor as an anticancer agent.

Derek J. Norris, D. Shen, G. Trainor, 2015, Bioorganic & medicinal chemistry letters.

Prodrugs of Amides, Imides and Other NH-acidic Compounds

V. Stella, Victor R. Guarino, 2007 .

Preparation, characterization and in vivo conversion of new water-soluble sulfenamide prodrugs of carbamazepine.

V. Stella, Victor R. Guarino, J. Hemenway, 2007, Bioorganic & medicinal chemistry letters.

Discovery of Clinical Candidate BMS-906024: A Potent Pan-Notch Inhibitor for the Treatment of Leukemia and Solid Tumors.

Derek J. Norris, D. Shen, G. Trainor, 2015, ACS medicinal chemistry letters.

Determination of the permeability characteristics of two sulfenamide prodrugs of linezolid across Caco-2 cells.

V. Stella, G. Dalwadi, Victor R. Guarino, 2012, Journal of pharmaceutical sciences.

Discovery of Potent and Selective Quinoxaline-Based Protease-Activated Receptor 4 (PAR4) Antagonists for the Prevention of Arterial Thrombosis.

Shana L. Posy, R. Wexler, J. M. Richter, 2024, Journal of medicinal chemistry.