L. Tota

发表

Glucagon-Like Peptide 1/Glucagon Receptor Dual Agonism Reverses Obesity in Mice

Michael E. Lassman, N. Thornberry, Gaochao Zhou, 2009, Diabetes.

Potent and selective human beta(3)-adrenergic receptor antagonists.

A. Weber, M. Cascieri, M. Candelore, 1999, The Journal of pharmacology and experimental therapeutics.

A novel series of indazole-/indole-based glucagon receptor antagonists.

S. Qureshi, Bei B. Zhang, G. Salituro, 2015, Bioorganic & medicinal chemistry letters.

Design and synthesis of conformationally constrained tri-substituted ureas as potent antagonists of the human glucagon receptor.

V. Ding, Bei B. Zhang, J. Tata, 2007, Bioorganic & medicinal chemistry letters.

Discovery of novel, potent, and orally active spiro-urea human glucagon receptor antagonists.

V. Ding, S. Qureshi, K. Chapman, 2005, Bioorganic & medicinal chemistry letters.

L-750355, a human beta3-adrenoceptor agonist; in vitro pharmacology and profile of activity in vivo in the rhesus monkey.

C. Strader, T. Bach, M. Fisher, 2000, European journal of pharmacology.

Desensitization of beta3-adrenergic receptor-stimulated adenylyl cyclase activity and lipolysis in rats.

D. Macintyre, P. Vicario, L. Kelly, 1998, Life sciences.

Phytosphingosine 1-phosphate: a high affinity ligand for the S1P(4)/Edg-6 receptor.

M. Candelore, S. Mandala, J. Bergstrom, 2002, Biochemical and biophysical research communications.

A novel glucagon receptor antagonist inhibits glucagon-mediated biological effects.

D. Moller, V. Ding, S. Qureshi, 2004, Diabetes.

Discovery of potent, orally active benzimidazole glucagon receptor antagonists.

V. Ding, S. Qureshi, D. Szalkowski, 2008, Bioorganic & medicinal chemistry letters.

Discovery and investigation of a novel class of thiophene-derived antagonists of the human glucagon receptor.

V. Ding, S. Qureshi, D. Szalkowski, 2005, Bioorganic & medicinal chemistry letters.

Substituted oxazole benzenesulfonamides as potent human beta3 adrenergic receptor agonists.

C. Strader, D. Macintyre, M. Forrest, 2000, Bioorganic & medicinal chemistry letters.

Discovery of L-755,507: A subnanomolar human β3 adrenergic receptor agonist

C. Strader, M. Fisher, M. Wyvratt, 1998 .

Human beta3 adrenergic receptor agonists containing cyclic ureidobenzenesulfonamides.

R. Miller, C. Strader, D. Macintyre, 1999, Bioorganic & medicinal chemistry letters.

Discovery of an orally bioavailable alkyl oxadiazole beta3 adrenergic receptor agonist.

R. Miller, C. Strader, D. Macintyre, 2000, Bioorganic & medicinal chemistry letters.

Human beta3 adrenergic receptor agonists containing cyanoguanidine and nitroethylenediamine moieties.

M. Fisher, M. Wyvratt, A. Weber, 2001, Bioorganic & medicinal chemistry letters.

Potent, elective human beta3 adrenergic receptor agonists containing a substituted indoline-5-sulfonamide pharmacophore.

C. Strader, M. Fisher, M. Wyvratt, 1999, Bioorganic & medicinal chemistry letters.

L-770,644: a potent and selective human beta3 adrenergic receptor agonist with improved oral bioavailability.

R. Miller, C. Strader, D. Macintyre, 1999, Bioorganic & medicinal chemistry letters.

Discovery of a potent, orally bioavailable beta(3) adrenergic receptor agonist, (R)-N-[4-[2-[[2-hydroxy-2-(3-pyridinyl)ethyl]amino]ethyl]phenyl]-4-[4 -[4-(trifluoromethyl)phenyl]thiazol-2-yl]benzenesulfonamide.

R. Miller, D. Macintyre, M. Forrest, 2000, Journal of medicinal chemistry.

Tetrahydroisoquinoline derivatives containing a benzenesulfonamide moiety as potent, selective human beta3 adrenergic receptor agonists.

M. Fisher, M. Wyvratt, A. Weber, 2000, Bioorganic & medicinal chemistry letters.

Discovery of a novel glucagon receptor antagonist N-[(4-{(1S)-1-[3-(3, 5-dichlorophenyl)-5-(6-methoxynaphthalen-2-yl)-1H-pyrazol-1-yl]ethyl}phenyl)carbonyl]-β-alanine (MK-0893) for the treatment of type II diabetes.

S. Qureshi, S. Xu, Bei B. Zhang, 2012, Journal of medicinal chemistry.

Human beta3-adrenergic receptor agonists containing 1,2,3-triazole-substituted benzenesulfonamides.

D. Macintyre, M. Forrest, M. Fisher, 2000, Bioorganic & medicinal chemistry letters.

Potent, selective benzenesulfonamide agonists of the human beta 3 adrenergic receptor.

C. Strader, M. Fisher, M. Wyvratt, 1998, Bioorganic & medicinal chemistry letters.

Discovery of novel, potent, selective, and orally active human glucagon receptor antagonists containing a pyrazole core.

V. Ding, S. Qureshi, K. Chapman, 2011, Bioorganic & medicinal chemistry letters.

Discovery of N-aryl-2-acylindole human glucagon receptor antagonists.

V. Ding, S. Qureshi, D. Szalkowski, 2011, Bioorganic & medicinal chemistry letters.

Discovery of cyclic guanidines as potent, orally active, human glucagon receptor antagonists.

V. Ding, S. Qureshi, D. Szalkowski, 2011, Bioorganic & medicinal chemistry letters.

3-Pyridyloxypropanolamine agonists of the beta 3 adrenergic receptor with improved pharmacokinetic properties.

R. Miller, C. Strader, D. Macintyre, 1998, Bioorganic & medicinal chemistry letters.

GLP-1/GCGR dual agonism reverses obesity in mice Short-running title: Dual GLP-1/GCGR agonist for the treatment of obesity

Michael E. Lassman, N. Thornberry, Gaochao Zhou, 2009 .

Direct observation (NMR) of the efficacy of glucagon receptor antagonists in murine liver expressing the human glucagon receptor.

V. Ding, Bei B. Zhang, G. Kaczorowski, 2006, Bioorganic & Medicinal Chemistry.

3-Pyridylethanolamines: potent and selective human beta 3 adrenergic receptor agonists.

C. Strader, D. Macintyre, M. Forrest, 1998, Bioorganic & medicinal chemistry letters.

Pharmacological characterization of a recently described human beta 3-adrenergic receptor mutant.

C. Strader, L. Kelly, M. Cascieri, 1996, Endocrinology.

Human beta3 adrenergic receptor agonists containing imidazolidinone and imidazolone benzenesulfonamides.

C. Strader, D. Macintyre, M. Forrest, 1999, Bioorganic & medicinal chemistry letters.

Discovery of L-755,507: A Subnanomolar Human β3 Adrenergic Receptor Agonist.

C. Strader, M. Wyvratt, A. Weber, 1998 .

A selective human beta3 adrenergic receptor agonist increases metabolic rate in rhesus monkeys.

R. Miller, C. Strader, J. Metzger, 1998, The Journal of clinical investigation.

Discovery of L-755,507: a subnanomolar human beta 3 adrenergic receptor agonist.

C. Strader, M. Fisher, M. Wyvratt, 1998, Bioorganic & medicinal chemistry letters.