I. Bjorkhem

发表

Cholesterol binding to cytochrome P450 7A1, a key enzyme in bile acid biosynthesis.

J. Peterson, I. Pikuleva, S. Graham, 2005, Biochemistry.

On the substrate specificity of human CYP27A1: implications for bile acid and cholestanol formation.

M. Norlin, K. Wikvall, I. Bjorkhem, 2003, Journal of lipid research.

Broad substrate specificity of human cytochrome P450 46A1 which initiates cholesterol degradation in the brain.

I. Pikuleva, Natalia Mast, M. Shou, 2003, Biochemistry.

Transcriptional and post-translational changes in the brain of mice deficient in cholesterol removal mediated by cytochrome P450 46A1 (CYP46A1)

I. Pikuleva, Natalia Mast, Kyle W. Anderson, 2017, PloS one.

Inhibition of human sterol delta 7-reductase and other post-lanosterol enzymes by 2-(4-phenethylpiperazin-1-yl)-1-(pyridine-3-yl)ethanol (LK-980), a novel inhibitor of cholesterol synthesis

J. Pascussi, K. Monostory, D. Rozman, 2010 .

Cholestenoic Acid is an important elimination product of cholesterol in the retina: comparison of retinal cholesterol metabolism with that in the brain.

Suber S. Huang, I. Pikuleva, Natalia Mast, 2011, Investigative ophthalmology & visual science.

Marked variability in hepatic expression of cytochromes CYP7A1 and CYP27A1 as compared to cerebral CYP46A1. Lessons from a dietary study with omega 3 fatty acids in hamsters.

G. Ansari, W. Zaman, T. Wood, 2010, Biochimica et biophysica acta.

24(S),25-epoxycholesterol--a potential friend.

U. Diczfalusy, I. Bjorkhem, 2004, Arteriosclerosis, thrombosis, and vascular biology.

A Simple , FullyEnzymicBioluminescentAssayfor Triglyceridesin Serum

K. Sandelin, A. Thore, I. Bjorkhem, 2004 .

A novel specific assay of 25-hydroxy vitamin D.

I. Holmberg, I. Bjorkhem, 1976, Clinica chimica acta; international journal of clinical chemistry.

Vasculoprotective properties of plasma lipoproteins from brown bears (Ursus arctos)

J. Arnemo, J. Kindberg, U. Aasa, 2021, Journal of lipid research.

Mass Fragmentographyof Creatinine Proposedas a Reference Method

I. Bjorkhem, G. Ohman, RoIf Blomstrand, 2004 .

Formation of chenodeoxycholic acid from 3 a , 7 a = di hydroxy-5 ~-cholestanoic acid by rat liver peroxisomes

J. I. Pedersen, K. Prydz, B. F. Kase, 2002 .

ABCG1 Is Required for Pulmonary B-1 B Cell and Natural Antibody Homeostasis

J. Witztum, D. Ford, Á. Baldán, 2014, The Journal of Immunology.

Impaired Development of Atherosclerosis in Abcg1−/− Apoe−/− Mice: Identification of Specific Oxysterols That Both Accumulate in Abcg1−/− Apoe−/− Tissues and Induce Apoptosis

P. Edwards, A. Lusis, D. Bojanic, 2010, Arteriosclerosis, thrombosis, and vascular biology.

Subcellular localization of 3~t,7~~-dihydroxy- and 3~ ,7a ,12a=tri hydroxy=5~-cholestanoyl-coenzyme A ligase(s) in rat liver

J. I. Pedersen, K. Prydz, F. Kase, 1988 .

26-Hydroxylation of SP-cholestane-3 a , 7 a , 1 2 a-triol by isolated nonparenchymal cells and hepatocytes from rat liver

C. Drevon, J. I. Pedersen, S. Dueland, 2002 .

Studies on the link between HMG-CoA reductase and cholesterol 7 ~ hydroxylase in rat liver

Jan-Erik, I. Bjorkhem, kerlund, 2003 .

Comparisonof Two Isotope Dilution / Mass SpectrometricMethodsfor Determinationof TotalSerum Cholesterol

J. Mandel, M. Welch, H. Hertz, 2004 .

Comparison ofTwoIsotope Dilution/MassSpectrometric Methods for Determination ofTotalSerumCholesterol

J. Mandel, M. Welch, H. Hertz, 1982 .

On the quantitative importance of o-oxidation of fatty acids

I. Bjorkhem, 2002 .

Inhibition of Human Sterol Δ7-Reductase and Other Postlanosterol Enzymes by LK-980, a Novel Inhibitor of Cholesterol Synthesis

Uroš Urleb, Damjana Rozman, Darko Kocjan, 2011, Drug Metabolism and Disposition.

Crystal structures of substrate-bound and substrate-free cytochrome P450 46A1, the principal cholesterol hydroxylase in the brain

Eric F. Johnson, C. Stout, I. Pikuleva, 2008, Proceedings of the National Academy of Sciences.

Formation of cholic acid from 3a,7a, 12a-trihydroxy- 5P-cholestanoic acid by rat liver peroxisomes

J. I. Pedersen, F. Kase, I. Bjorkhem, 1983 .

Two genes that map to the STSL locus cause sitosterolemia: genomic structure and spectrum of mutations involving sterolin-1 and sterolin-2, encoded by ABCG5 and ABCG8, respectively.

A. Pandya, A. Brooks-Wilson, H. Brewer, 2001, American journal of human genetics.

Expression of human cytochrome P450 46A1 in Escherichia coli: effects of N- and C-terminal modifications.

I. Pikuleva, Natalia Mast, K. Nakayama, 2004, Archives of biochemistry and biophysics.

POSSIBILITY OF PRENATAL DIAGNOSIS OF ZELLWEGER SYNDROME

L. Hagenfeldt, R. Blomstrand, F. Kase, 1984, The Lancet.

Determination of serum levels of unesterified lathosterol by isotope dilution-mass spectrometry.

E. Lund, E. Reihnér, I. Bjorkhem, 1989, Scandinavian journal of clinical and laboratory investigation.

Use of complementary cation and anion heavy-atom salt derivatives to solve the structure of cytochrome P450 46A1

Eric F. Johnson, C. Stout, I. Pikuleva, 2008, Acta Crystallographica Section D: Biological Crystallography.

Phospholipids modify substrate binding and enzyme activity of human cytochrome P450 27A1 Published, JLR Papers in Press, September 1, 2004. DOI 10.1194/jlr.M400300-JLR200

G. Ansari, I. Pikuleva, U. Andersson, 2004, Journal of Lipid Research.

Cytochrome P450 27A1 Deficiency and Regional Differences in Brain Sterol Metabolism Cause Preferential Cholestanol Accumulation in the Cerebellum*

C. Tatsuoka, I. Turko, I. Pikuleva, 2017, The Journal of Biological Chemistry.

Properties of a reconstituted vitamin D3 25-hydroxylase from rat liver mitochondria.

J. I. Pedersen, I. Björkhem, H. Oftebro, 1980, The Journal of biological chemistry.

Cerebrotendinous xanthomatosis in the Israeli Druze: molecular genetics and phenotypic characteristics.

Y. Friedlander, V. Meiner, R. Safadi, 1994, American journal of human genetics.

Correlation between serum levels of some cholesterol precursors and activity of HMG-CoA reductase in human liver.

K. Einarsson, B. Angelin, T. Miettinen, 1987, Journal of lipid research.

Distinct binding of cholesterol and 5beta-cholestane-3alpha,7alpha,12alpha-triol to cytochrome P450 27A1: evidence from modeling and site-directed mutagenesis studies.

J. Halpert, Hong Liu, J. Peterson, 2006, Biochemistry.

Hepatic uptake of bile acids in man. Fasting and postprandial concentrations of individual bile acids in portal venous and systemic blood serum.

K. Einarsson, B. Angelin, I. Björkhem, 1982, The Journal of clinical investigation.

CREM modulates the circadian expression of CYP51, HMGCR and cholesterogenesis in the liver.

Jure Acimovic, P. Sassone-Corsi, D. Rozman, 2008, Biochemical and biophysical research communications.

A novel route for the biosynthesis of cholestanol, and its significance for the pathogenesis of cerebrotendinous xanthomatosis.

I. Bjorkhem, S. Skrede, 1985, Scandinavian journal of clinical and laboratory investigation. Supplementum.

Individual serum bile acid concentrations in normo- and hyperlipoproteinemia as determined by mass fragmentography: relation to bile acid pool size.

K. Einarsson, B. Angelin, I. Bjorkhem, 1978, Journal of lipid research.

Cerebrotendinous xanthomatosis: defective liver mitochondrial hydroxylation of chenodeoxycholic acid precursors.

J. I. Pedersen, I. Björkhem, H. Oftebro, 1981, Journal of lipid research.

Inhibition of Human Sterol Δ7-Reductase and Other Postlanosterol Enzymes by LK-980, a Novel Inhibitor of Cholesterol Synthesis

J. Pascussi, Jure Acimovic, K. Monostory, 2011, Drug Metabolism and Disposition.

CombinedEnzymic-Jaff # { 233 } Methodfor Determinationof Creatininein Serum

P. Ohlsson, I. Bjorkhem, P. Masson, 2004 .

Hepatic cholesterol metabolism in normo- and hyperlipidemic patients with cholesterol gallstones.

J. Ahlberg, K. Einarsson, B. Angelin, 1979, Journal of lipid research.

Regulation of hepatic cholesterol metabolism in humans: stimulatory effects of cholestyramine on HMG-CoA reductase activity and low density lipoprotein receptor expression in gallstone patients.

K. Einarsson, B. Angelin, M. Rudling, 1990, Journal of lipid research.