B. Johns

发表

A Phase IIa Study Evaluating Safety, Pharmacokinetics, and Antiviral Activity of GSK2838232, a Novel, Second-generation Maturation Inhibitor, in Participants With Human Immunodeficiency Virus Type 1 Infection.

M. Ramgopal, E. Dejesus, E. Dumont, 2019, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

The safety, tolerability, and pharmacokinetic profile of GSK2838232, a novel 2nd generation HIV maturation inhibitor, as assessed in healthy subjects

S. Baldwin, M. Davies, Mark Johnson, 2018, Pharmacology research & perspectives.

Carbamoyl pyridone HIV-1 integrase inhibitors. 1. Molecular design and establishment of an advanced two-metal binding pharmacophore.

T. Seki, T. Fujiwara, T. Yoshinaga, 2012, Journal of medicinal chemistry.

S/GSK1349572 is a Potent Next Generation HIV Integrase Inhibitor

E. Garvey, S. Foster, T. Fujiwara, 2009 .

Selection of diverse and clinically relevant integrase inhibitor-resistant human immunodeficiency virus type 1 mutants.

E. Garvey, T. Seki, S. Foster, 2008, Antiviral research.

Secondary mutations in viruses resistant to HIV-1 integrase inhibitors that restore viral infectivity and replication kinetics.

E. Garvey, T. Seki, S. Foster, 2009, Antiviral research.

Dolutegravir (S/GSK1349572) Exhibits Significantly Slower Dissociation than Raltegravir and Elvitegravir from Wild-Type and Integrase Inhibitor-Resistant HIV-1 Integrase-DNA Complexes

T. Seki, K. Weaver, F. Deanda, 2011, Antimicrobial Agents and Chemotherapy.

Discovery of a potent boronic acid derived inhibitor of the HCV RNA-dependent RNA polymerase.

R. Hamatake, Z. Hong, Shawn P. Williams, 2014, Journal of medicinal chemistry.

CTLA-4 and PD-1 dual blockade induces SIV reactivation without control of rebound after antiretroviral therapy interruption

J. Lifson, D. Margolis, K. Bar, 2020, Nature Medicine.

Inhibition of the Ribonuclease H Activity of HIV-1 Reverse Transcriptase by GSK5750 Correlates with Slow Enzyme-Inhibitor Dissociation*

G. Beilhartz, M. Götte, F. Deanda, 2014, The Journal of Biological Chemistry.

Pyrazolo[1,5-a]pyridines: synthetic approaches to a novel class of antiherpetics

M. Peel, K. Gudmundsson, F. Boyd, 2003 .

HIV-1 Integrase Strand Transfer Inhibitors

B. Johns, 2010 .

Carbamoyl pyridone HIV-1 integrase inhibitors. 2. Bi- and tricyclic derivatives result in superior antiviral and pharmacokinetic profiles.

E. Garvey, T. Seki, T. Fujiwara, 2013, Journal of medicinal chemistry.

A Scaleable Synthesis of Methyl 3-Amino-5-(4-fluorobenzyl)-2-pyridinecarboxylate

S. A. Burova, M. Sharp, C. Koble, 2007 .

Choosing the right antibody for resistin-like molecule (RELM/FIZZ) family members

R. Johns, Qingning Su, I. Kolosova, 2013, Histochemistry and Cell Biology.

Pyridopyrimidinone inhibitors of HIV-1 RNase H.

L. Leesnitzer, K. Hightower, B. Johns, 2014, European journal of medicinal chemistry.

Identification of 2,2-Dimethylbutanoic Acid (HST5040), a Clinical Development Candidate for the Treatment of Propionic Acidemia and Methylmalonic Acidemia.

B. Henke, M. S. Collado, R. Figler, 2021, Journal of medicinal chemistry.

A novel small molecule approach for the treatment of propionic and methylmalonic acidemias.

B. Henke, M. S. Collado, R. Figler, 2021, Molecular genetics and metabolism.

Pyrazolopyridines with potent activity against herpesviruses: effects of C5 substituents on antiviral activity.

K. Gudmundsson, B. Johns, Scott H. Allen, 2008, Bioorganic & medicinal chemistry letters.

The use of oxadiazole and triazole substituted naphthyridines as HIV-1 integrase inhibitors. Part 1: Establishing the pharmacophore.

E. Garvey, S. Foster, J. Jeffrey, 2009, Bioorganic & medicinal chemistry letters.

Pyrazolo[1,5-a]pyridine antiherpetics: effects of the C3 substituent on antiviral activity.

K. Gudmundsson, B. Johns, Scott H. Allen, 2007, Bioorganic & medicinal chemistry letters.

1,3,4-Oxadiazole substituted naphthyridines as HIV-1 integrase inhibitors. Part 2: SAR of the C5 position.

E. Garvey, S. Foster, J. Jeffrey, 2009, Bioorganic & medicinal chemistry letters.

Imidazo[1,2-a]pyridines with potent activity against herpesviruses.

K. Gudmundsson, B. Johns, 2007, Bioorganic & medicinal chemistry letters.

Synthesis of novel imidazo[1,2-a]pyridines with potent activity against herpesviruses.

K. Gudmundsson, B. Johns, 2003, Organic letters.

Scaffolded bis-azasugars: A dual warhead approach to glycosidase inhibition

Carl R. Johnson, B. Johns, 1998 .

Pyrazolopyridines with potent activity against herpesviruses: effects of C5 substituents on antiviral activity.

K. Gudmundsson, B. Johns, Scott H. Allen, 2008, Bioorganic & medicinal chemistry letters.

The design of 8-hydroxyquinoline tetracyclic lactams as HIV-1 integrase strand transfer inhibitors.

Emile J Velthuisen, Brian A Johns, David P Temelkoff, 2016, European journal of medicinal chemistry.

Synthesis of C-6 substituted pyrazolo[1,5-a]pyridines with potent activity against herpesviruses.

G. A. Freeman, K. Gudmundsson, K. Creech, 2006, Bioorganic & medicinal chemistry.

Stereoselective synthesis of C5-C20 and C21-C34 subunits of the core structure of the aplyronines. Applications of enantioselective additions of chiral allenylindium reagents to chiral aldehydes.

J. A. Marshall, B. Johns, 2000, The Journal of organic chemistry.

Synthesis of novel substituted 2-phenylpyrazolopyridines with potent activity against herpesviruses.

G. A. Freeman, K. Gudmundsson, Zhicheng Wang, 2005, Bioorganic & medicinal chemistry.

Synthesis and Utilization of Indium (I) Iodide for in Situ Formation of Enantioenriched Allenylindium Reagents and their Addition to Aldehydes: (2R,3S,4S)-1-(tert-Butyldiphenylsilyloxy)-2,4-Dimethyl-5-Hexyn-3-ol

J. A. Marshall, B. Johns, C. M. Grant, 2003 .

Synthesis and Biological Evaluation of Aza-C-disaccharides: (1→6), (1→4), and (1→1) Linked Sugar Mimics

Carl R. Johnson, Yanbin Pan, A. D. Elbein, 1997 .

Synthesis of Carbohydrate Mimics: α-1-C-Substituted-deoxymannojirimycins

Carl R. Johnson, B. Johns, 1997 .

Synthesis and antiviral activity of 7-benzyl-4-hydroxy-1,5-naphthyridin-2(1H)-one HIV integrase inhibitors.

E. Garvey, S. Foster, T. Fujiwara, 2009, Journal of medicinal chemistry.

In Vitro Antiretroviral Properties of S/GSK1349572, a Next-Generation HIV Integrase Inhibitor

Shigeru Miki, Akihiko Sato, Kevin W. Brown, 2010, Antimicrobial Agents and Chemotherapy.

Conformational Behavior of Aza-C-Glycosides: Experimental Demonstration of the Relative Role of the exo-anomeric Effect and 1,3-Type Interactions in Controlling the Conformation of Regular Glycosides

F. Cañada, J. L. Asensio, A. Fernández-Mayoralas, 1999 .

Synthesis and HIV-integrase strand transfer inhibition activity of 7-hydroxy[1,3]thiazolo[5,4-b]pyridin-5(4H)-ones.

E. Garvey, C. Koble, W. H. Miller, 2006, Bioorganic & medicinal chemistry letters.

Antiviral Characteristics of GSK1265744, an HIV Integrase Inhibitor Dosed Orally or by Long-Acting Injection

E. Garvey, T. Seki, T. Fujiwara, 2014, Antimicrobial Agents and Chemotherapy.

Naphthyridinone (NTD) integrase inhibitors 4. Investigating N1 acetamide substituent effects with C3 amide groups.

E. Garvey, S. Foster, T. Fujiwara, 2014, Bioorganic & medicinal chemistry letters.

Naphthyridinone (NTD) integrase inhibitors: N1 protio and methyl combination substituent effects with C3 amide groups.

E. Garvey, S. Foster, T. Fujiwara, 2013, Bioorganic & medicinal chemistry letters.

Combining symmetry elements results in potent naphthyridinone (NTD) HIV-1 integrase inhibitors.

E. Garvey, S. Foster, T. Fujiwara, 2011, Bioorganic & medicinal chemistry letters.

Pharmacovirological Impact of an Integrase Inhibitor on Human Immunodeficiency Virus Type 1 cDNA Species In Vivo

Steven J Novick, Steven J. Novick, E. Garvey, 2009, Journal of Virology.

Pharmacovirological Impact of an Integrase Inhibitor on Human Immunodeﬁciency Virus Type 1 cDNA Species In Vivo (cid:1)

Steven J. Novick, E. Garvey, K. Chiswell, 2009 .

The Naphthyridinone GSK364735 Is a Novel, Potent Human Immunodeficiency Virus Type 1 Integrase Inhibitor and Antiretroviral

E. Garvey, S. Foster, T. Fujiwara, 2007, Antimicrobial Agents and Chemotherapy.

Advances in two-metal chelation inhibitors of HIV integrase

B. Johns, Angilique Svolto, 2008 .

Synthesis and pharmacokinetic profile of highly deuterated brecanavir analogs.

T. Baughman, B. Johns, D. Temelkoff, 2013, European journal of medicinal chemistry.

Pyrazolopyrimidines and pyrazolotriazines with potent activity against herpesviruses.

K. Gudmundsson, B. Johns, J. Weatherhead, 2009, Bioorganic & medicinal chemistry letters.

Synthesis of Discodermolide Subunits by S(E)2' Addition of Nonracemic Allenylstannanes to Aldehydes.

Zhi-Hui Lu, J. A. Marshall, B. Johns, 1998, The Journal of organic chemistry.

1‐Amino‐Pyridinium Iodide

B. Johns, 2008 .

Carbamoyl pyridone HIV-1 integrase inhibitors 3. A diastereomeric approach to chiral nonracemic tricyclic ring systems and the discovery of dolutegravir (S/GSK1349572) and (S/GSK1265744).

E. Garvey, T. Seki, S. Foster, 2013, Journal of medicinal chemistry.

Glycomimetics: A Versatile de Novo Synthesis of β-1-C-Aryl-deoxymannojirimycin Analogues

Carl R. Johnson, B. Johns, 1997 .

Pyrazolopyridine antiherpetics: SAR of C2' and C7 amine substituents.

J. A. Ray, V. Samano, G. A. Freeman, 2005, Bioorganic & medicinal chemistry.

Synthesis of novel imidazo[1,2-a]pyridines with potent activity against herpesviruses.

K. Gudmundsson, B. Johns, 2003, Organic letters.

Discovery of a novel and potent class of anti-HIV-1 maturation inhibitors with improved virology profile against gag polymorphisms.

C. McDanal, D. Irlbeck, Stacey A. Jones, 2017, Bioorganic & medicinal chemistry letters.

Synthesis and Biological Evaluation of Macrocyclized Betulin Derivatives as a Novel Class of Anti-HIV-1 Maturation Inhibitors

Heping Yang, C. McDanal, D. Irlbeck, 2014, The open medicinal chemistry journal.

Novel cleavage of reductively aminated glycan-tags by N-bromosuccinimide to regenerate free, reducing glycans.

David F. Smith, Xuezheng Song, Yi Lasanajak, 2013, ACS chemical biology.

CTLA-4 and PD-1 dual blockade induces SIV reactivation without control of rebound after antiretroviral therapy interruption

J. Lifson, D. Margolis, K. Bar, 2020, Nature Medicine.

A Phase 1 Study to Assess the Relative Bioavailability, Food Effect, and Safety of a Tablet Formulation of GSK2838232, a Novel HIV Maturation Inhibitor in Healthy Participants After Single and Repeated Doses

E. Dumont, Mark Johnson, R. Jewell, 2020, Clinical pharmacology in drug development.

The Activity of the Integrase Inhibitor Dolutegravir Against HIV-1 Variants Isolated From Raltegravir-Treated Adults

Jeffrey N. Martin, S. Deeks, T. Fujiwara, 2012, Journal of acquired immune deficiency syndromes.