Qianru Wei

Lck bound to coreceptor is less active than free Lck

Shvetha Sankaran, Lukasz Wojciech, N. Gascoigne, 2020, Proceedings of the National Academy of Sciences.

Ligand engaged TCR is triggered by Lck not associated with CD8 coreceptor

R. Zamoyska, V. Zarnitsyna, Cheng Zhu, 2014, Nature Communications.

Signaling from T cell receptors (TCRs) and chimeric antigen receptors (CARs) on T cells

N. Gascoigne, J. Brzostek, Ling-Tao Wu, 2020, Cellular & Molecular Immunology.

CD28-CAR-T cell activation through FYN kinase signaling rather than LCK enhances therapeutic performance

P. MacAry, N. Gascoigne, J. Brzostek, 2023, Cell reports. Medicine.

Targeting CAR to the Peptide-MHC Complex Reveals Distinct Signaling Compared to That of TCR in a Jurkat T Cell Model

Shvetha Sankaran, P. MacAry, N. Gascoigne, 2021, Cancers.

Signaling from T cell receptors (TCRs) and chimeric antigen receptors (CARs) on T cells

N. Gascoigne, J. Brzostek, Qianru Wei, 2020, Cellular & Molecular Immunology.

Canonical T cell receptor docking on peptide–MHC is essential for T cell signaling

K. Gaus, C. Szeto, J. Rossjohn, 2021, Science.

Non-Stimulatory pMHC Enhance CD8 T Cell Effector Functions by Recruiting Coreceptor-Bound Lck

N. Gascoigne, J. Brzostek, Qianru Wei, 2021, Frontiers in Immunology.