L. Hsin

发表

Activation of serotonin 5-HT₇ receptor induces coronary flow increase in isolated rat heart.

M. Su, Ching-Chia Chang Chien, L. Hsin, 2015, European journal of pharmacology.

Anthracenedione-methionine conjugates are novel topoisomerase II-targeting anticancer agents with favorable drug resistance profiles.

Hsiang-Chin Chen, Tsai-Kun Li, N. Chan, 2012, Biochemical pharmacology.

5-HT7 receptor-dependent intestinal neurite outgrowth contributes to visceral hypersensitivity in irritable bowel syndrome

L. Yu, C. Tu, Ming-Shiang Wu, 2022, Laboratory Investigation.

Synthesis and analysis of 4-(3-fluoropropyl)-glutamic acid stereoisomers to determine the stereochemical purity of (4S)-4-(3-[18F]fluoropropyl)-L-glutamic acid ([18F]FSPG) for clinical use

Y. Tien, C. Shiue, M. Cheng, 2020, PloS one.

Synthesis of 3-[4-Acyl-2-(1-methoxy-1-methylethyl)morpholin-3-yl]-benzonitriles as Novel Potassium Channel Openers

L. Hsin, Chen-Yu Cheng, M. Lin, 2004 .

N-Arylated pyrrolidin-2-ones and morpholin-3-ones as potassium channel openers.

P. Liang, L. Hsin, Chen-Yu Cheng, 2002, Bioorganic & medicinal chemistry.

Synthesis and evaluation of 2-(2'-((dimethylamino)methyl)-4'-(2-fluoroethoxy-substituted)phenylthio)benzenamine derivatives as potential positron emission tomography imaging agents for serotonin transporters.

Hsin-Yi Shen, C. Shiue, K. Tzen, 2020, Bioorganic chemistry.

WRC-213, an l-methionine-conjugated mitoxantrone derivative, displays anticancer activity with reduced cardiotoxicity and drug resistance: identification of topoisomerase II inhibition and apoptotic machinery in prostate cancers.

P. Lyu, J. Guh, C. Liao, 2008, Biochemical pharmacology.

action illuminated through optical monitoring of synaptic vesicles in Drosophila brain.

R. Freyberg, J. Flores, D. Sulzer, 2016 .

5-HT7 receptor-dependent intestinal neurite outgrowth contributes to visceral hypersensitivity in irritable bowel syndrome

L. Yu, C. Tu, Ming-Shiang Wu, 2022, Laboratory Investigation.

A Novel Potential Positron Emission Tomography Imaging Agent for Vesicular Monoamine Transporter Type 2

C. Shiue, Zih-rou Huang, R. Yen, 2016, PloS one.

The effects of CRF antagonists, antalarmin, CP154,526, LWH234, and R121919, in the forced swim test and on swim-induced increases in adrenocorticotropin in rats

H. Houshyar, E. Jutkiewicz, K. Rice, 2005, Psychopharmacology.

Topoisomerase II inhibition suppresses the proliferation of telomerase-negative cancers

S. Teng, Tsai-Kun Li, Chuan-Chuan Lin, 2015, Cellular and Molecular Life Sciences.

Selective reversible and irreversible ligands for the kappa opioid receptor.

S. Tam, L. Hsin, C. Cheng, 1992, Journal of medicinal chemistry.

Quinazolin-4-one derivatives as selective histone deacetylase-6 inhibitors for the treatment of Alzheimer's disease.

J. Chern, Ji-Wang Chern, Chao-Wu Yu, 2013, Journal of medicinal chemistry.

Novel radical synthesis of morphine fragments spiro[benzofuran-3(2H),4′-piperidine] and octahydro-1H-benzofuro[3,2-e]isoquinoline

J. Liou, L. Hsin, Chen‐Yu Cheng, 1996 .

Inhibitor development of MTH1 via high-throughput screening with fragment based library and MTH1 substrate binding cavity.

H. Juan, J. Chern, Yi-Sheng Cheng, 2021, Bioorganic chemistry.

A concise synthesis of (S)-(+)-1-(4-{2-[bis-(4-fluorophenyl)methoxy]-ethyl} piperazin-1-yl)-2-phenylpropan-2-ol dimaleate

C. George, J. Flippen-Anderson, K. Rice, 2003 .

Synthesis and dopamine transporter affinity of chiral 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(2-hydroxypropyl)piperazines as potential cocaine abuse therapeutic agents.

K. Rice, R. Rothman, C. Dersch, 2003, Bioorganic & medicinal chemistry letters.

Development of long-acting dopamine transporter ligands as potential cocaine-abuse therapeutic agents: chiral hydroxyl-containing derivatives of 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine and 1-[2-(diphenylmethoxy)ethyl]-4-(3-phenylpropyl)piperazine.

K. Rice, R. Rothman, C. Dersch, 2002, Journal of medicinal chemistry.

Synthesis, DNA binding, and cytotoxicity of 1,4-bis(2-amino-ethylamino)anthraquinone-amino acid conjugates.

J. Guh, Tsai-Kun Li, Hung-Wei Chen, 2008, Bioorganic & medicinal chemistry.

Identification of a novel “almost neutral” μ‐opioid receptor antagonist in CHO cells expressing the cloned human μ‐opioid receptor

K. Rice, R. Rothman, C. Dersch, 2010, Synapse.

Mechanisms of amphetamine action illuminated through optical monitoring of dopamine synaptic vesicles in Drosophila brain

R. Freyberg, J. Flores, D. Sulzer, 2016, Nature Communications.

Intramolecular heck cyclization to the galanthamine-type alkaloids: total synthesis of (′)-lycoramine

L. Hsin, Pi-Hui Liang, Chen‐Yu Cheng, 2004 .

Synthesis of Galanthamine Analogs as Acetylcholinesterase Inhibitors via Intramolecular Heck Cyclization

L. Hsin, Chia-Huei Hsu, Pi-Hui Liang, 2003 .

N-cubylmethyl substituted morphinoids as novel narcotic antagonists.

P. Tao, T. Jong, L. Hsin, 1996, Bioorganic & medicinal chemistry.

Identification of Buctopamine and Mebuctopamine, a β2 Receptor Agonist and Its Metabolite, in Swine Hair and Feed Additives.

Yi-Ying Lin, L. Hsin, Chia-Ying Yang, 2017, Journal of agricultural and food chemistry.

A novel isoquinoline derivative exhibits anti-inflammatory properties and improves the outcomes of endotoxemia

S. Lee, M. Su, L. Hsin, 2019, Pharmacological reports : PR.

High‐selective HDAC6 inhibitor promotes HDAC6 degradation following autophagy modulation and enhanced antitumor immunity in glioblastoma

J. Chern, L. Hsin, Jia-rong Liu, 2019, Biochemical pharmacology.

Prospective comparison of (4S)-4-(3-18F-fluoropropyl)-l-glutamate versus 18F-fluorodeoxyglucose PET/CT for detecting metastases from pancreatic ductal adenocarcinoma: a proof-of-concept study

Y. Jeng, Y. Tien, C. Shiue, 2019, European Journal of Nuclear Medicine and Molecular Imaging.

An one-pot two-step automated synthesis of [18F]T807 injection, its biodistribution in mice and monkeys, and a preliminary study in humans

K. Ma, M. Chiu, C. Shiue, 2019, PloS one.

Improved enamine-type addition of dehydroaporphine using microwave irradiation

Jung-Hsin Lin, Shoei‐Sheng Lee, L. Hsin, 2010 .

Synthesis and biological evaluation of phenothiazine derivative-containing hydroxamic acids as potent class II histone deacetylase inhibitors.

Chien-Huang Lin, A. H. Wang, Wei-Jan Huang, 2021, European journal of medicinal chemistry.

Oxygenated analogues of 1-[2-(Diphenylmethoxy)ethyl]- and 1-[2-[Bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazines (GBR 12935 and GBR 12909) as potential extended-action cocaine-abuse therapeutic agents.

K. Rice, R. Rothman, C. Dersch, 1999, Journal of medicinal chemistry.

Design and synthesis of 2- and 3-substituted-3-phenylpropyl analogs of 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine and 1-[2-(diphenylmethoxy)ethyl]-4-(3-phenylpropyl)piperazine: role of amino, fluoro, hydroxyl, methoxyl, methyl, methylene, and oxo substituents on affinity fo

K. Rice, R. Rothman, C. Dersch, 2008, Journal of medicinal chemistry.

Synthesis and biological activity of fluoro-substituted pyrrolo[2,3-d]pyrimidines: the development of potential positron emission tomography imaging agents for the corticotropin-releasing hormone type 1 receptor.

G. Chrousos, C. Contoreggi, K. Rice, 2000, Bioorganic & medicinal chemistry letters.

The development of a potential single photon emission computed tomography (SPECT) imaging agent for the corticotropin-releasing hormone receptor type.

G. Chrousos, C. Contoreggi, K. Rice, 2001, Bioorganic & medicinal chemistry letters.

G. Chrousos, C. Contoreggi, K. Rice, 2000, Bioorganic & medicinal chemistry letters.

CRHR1 Receptor binding and lipophilicity of pyrrolopyrimidines, potential nonpeptide corticotropin-releasing hormone type 1 receptor antagonists.

G. Chrousos, C. Contoreggi, K. Rice, 2002, Bioorganic & medicinal chemistry.

Targeting breast cancer stem cells by novel HDAC3-selective inhibitors.

Hao-Yu Hsieh, H. Chuang, L. Hsin, 2017, European journal of medicinal chemistry.

Synthesis and biological evaluation of C-4 substituted phenoxazine-bearing hydroxamic acids with potent class II histone deacetylase inhibitory activities

Sung-Bau Lee, Wei-Jan Huang, K. Hsu, 2023, Journal of enzyme inhibition and medicinal chemistry.

F-fluorodeoxyglucose PET/CT for detecting metastases from pancreatic ductal adenocarcinoma: a proof-of-concept study

Y. Jeng, Y. Tien, C. Shiue, 2019 .

Synthesis and opioid activity of enantiomeric N-substituted 2,3,4,4a,5,6,7,7a-octahydro-1H-benzofuro[3,2-e]isoquinolines.

R. Rothman, C. Dersch, James A. Fishback, 2010, Journal of medicinal chemistry.

Synthesis of [3H](4-fluorobutyl)propyl[2,5,6-trimethyl-7-(2,4,6-trimethylphenyl)pyrrolo[2,3-d]pyrimidin-4-yl]amine: a potent radioligand for corticotropin-releasing hormone type 1 receptor

G. Chrousos, C. Contoreggi, K. Rice, 2000 .

Stereoselective synthesis of morphine fragments trans- and cis-octahydro-1H-benzo[4,5]furo[3,2-e]isoquinolines

Chien-Wei Chen, Hung-Wei Chen, L. Hsin, 2005 .

Synthesis and opioid activity of 7-oxygenated 2,3,4,4a,5,6,7,7a-octahydro-1H-benzofuro[3,2-e]isoquinolin-9-ols.

M. Tsai, S. Tam, W. Schmidt, 1994, Journal of Medicinal Chemistry.

Asymmetric Total Synthesis of (‐)‐Octahydro‐1H‐benzofuro[3,2‐e]isoquinoline, A Partial Structure of Morphine

Chien-Wei Chen, L. Hsin, Li-Te Chang, 2005 .