Alexander J Stevens

发表

SB-656104-A: a novel 5-HT(7) receptor antagonist with improved in vivo properties.

I. Forbes, G. Riley, P. Jeffrey, 2002, Bioorganic & medicinal chemistry letters.

Discovery and structure-activity relationships of a series of pyroglutamic acid amide antagonists of the P2X7 receptor.

S. Senger, P. Beswick, Robert J Gleave, 2010, Bioorganic & medicinal chemistry letters.

Discovery of SB-705498: a potent, selective and orally bioavailable TRPV1 antagonist suitable for clinical development.

A. Randall, G. Stemp, M. Gunthorpe, 2006, Bioorganic & medicinal chemistry letters.

Discovery of N-(3-fluorophenyl)-1-[(4-([(3S)-3-methyl-1-piperazinyl]methyl)phenyl)acetyl]-4-piperidinamine (GSK962040), the first small molecule motilin receptor agonist clinical candidate.

A. Muir, G. Sanger, Christopher N. Johnson, 2009, Journal of medicinal chemistry.

The discovery and optimisation of benzazepine sulfonamide and sulfones as potent agonists of the motilin receptor.

Jackie S. Scott, A. Muir, G. Sanger, 2009, Bioorganic & medicinal chemistry letters.

The discovery of biaryl carboxamides as novel small molecule agonists of the motilin receptor.

Michael A. Briggs, G. Macdonald, G. Sanger, 2008, Bioorganic & medicinal chemistry letters.

Discovery of potent and stable conformationally constrained analogues of the MCH R1 antagonist SB-568849.

G. Hervieu, A. Muir, K. Thewlis, 2006, Bioorganic & medicinal chemistry letters.

Identification of 2,3-diaryl-pyrazolo[1,5-b]pyridazines as potent and selective cyclooxygenase-2 inhibitors.

I. Chessell, A. Naylor, C. Bountra, 2004, Bioorganic & medicinal chemistry letters.

Optimization of sphingosine-1-phosphate-1 receptor agonists: effects of acidic, basic, and zwitterionic chemotypes on pharmacokinetic and pharmacodynamic profiles.

I. Wall, K. Philpott, T. Heightman, 2014, Journal of medicinal chemistry.

SB‐656104‐A, a novel selective 5‐HT7 receptor antagonist, modulates REM sleep in rats

J. Hagan, D. Middlemiss, C. Scott, 2003, British journal of pharmacology.

The Cyclooxygenase-2 Inhibitor GW406381X [2-(4-Ethoxyphenyl)-3-[4-(methylsulfonyl)phenyl]-pyrazolo[1,5-b]pyridazine] Is Effective in Animal Models of Neuropathic Pain and Central Sensitization

S. Summerfield, I. Chessell, A. Naylor, 2005, Journal of Pharmacology and Experimental Therapeutics.

SAR of biphenyl carboxamide ligands of the human melanin-concentrating hormone receptor 1 (MCH R1): discovery of antagonist SB-568849.

G. Hervieu, Shelagh Wilson, A. Muir, 2006, Bioorganic & medicinal chemistry letters.

Discovery of small molecule antagonists of TRPV1.

P. Wyman, A. Randall, M. Gunthorpe, 2004, Bioorganic & medicinal chemistry letters.

N-Tetrahydroquinolinyl, N-quinolinyl and N-isoquinolinyl biaryl carboxamides as antagonists of TRPV1.

G. Stemp, John B Davis, S. Medhurst, 2006, Bioorganic & medicinal chemistry letters.

Design and synthesis of 6-phenylnicotinamide derivatives as antagonists of TRPV1.

G. Stemp, M. Gunthorpe, John B Davis, 2008, Bioorganic & medicinal chemistry letters.

Synthesis and structure-activity relationships of a series of (1H-pyrazol-4-yl)acetamide antagonists of the P2X7 receptor.

S. Senger, P. Beswick, E. Demont, 2010, Bioorganic & medicinal chemistry letters.

Structure-activity relationships and in vivo activity of (1H-pyrazol-4-yl)acetamide antagonists of the P2X(7) receptor.

S. Senger, P. Beswick, Robert J Gleave, 2010, Bioorganic & medicinal chemistry letters.

Identification of [4-[4-(methylsulfonyl)phenyl]-6-(trifluoromethyl)-2-pyrimidinyl] amines and ethers as potent and selective cyclooxygenase-2 inhibitors.

I. Chessell, C. Bountra, S. Bingham, 2009, Bioorganic & medicinal chemistry letters.