Haytham O. Tawfik

发表

The plausible mechanisms of tramadol for treatment of COVID-19

K. Okasha, A. Goda, N. El‐Ashmawy, 2020, Medical Hypotheses.

Novel 3-(6-methylpyridin-2-yl)coumarin-based chalcones as selective inhibitors of cancer-related carbonic anhydrases IX and XII endowed with anti-proliferative activity

C. Supuran, Wagdy M. Eldehna, A. Nocentini, 2022, Journal of enzyme inhibition and medicinal chemistry.

New Genetic Bomb Trigger: Design, Synthesis, Molecular Dynamics Simulation, and Biological Evaluation of Novel BIBR1532-Related Analogs Targeting Telomerase against Non-Small Cell Lung Cancer

A. Veselovsky, D. Zhdanov, Y. Gladilina, 2022, Pharmaceuticals.

Synthesis, crystallographic, DNA binding, and molecular docking/dynamic studies of a privileged chalcone-sulfonamide hybrid scaffold as a promising anticancer agent

M. Sugiura, F. Belal, H. Elmansi, 2022, Journal of biomolecular structure & dynamics.

Investigating the potential anticancer activities of antibiotics as topoisomerase II inhibitors and DNA intercalators: in vitro, molecular docking, molecular dynamics, and SAR studies

Faten Farouk, Wagdy M. Eldehna, Ayman Abo Elmaaty, 2023, Journal of enzyme inhibition and medicinal chemistry.

Ligand-Based Design on the Dog-Bone-Shaped BIBR1532 Pharmacophoric Features and Synthesis of Novel Analogues as Promising Telomerase Inhibitors with In Vitro and In Vivo Evaluations.

S. Antar, Mohamed S. Nafie, Ayman Abo Elmaaty, 2022, Journal of medicinal chemistry.

Toxoplasmocidal and Cytotoxic Activities Guided Isolation and Characterization of an Undescribed Bioflavonoid-di-C-glucoside from Cycas rumphii Miq. Cultivated in Egypt

Mona El-Aasr, Haytham O. Tawfik, Kamilia A Abo El-Seoud, 2022, Plants.

Nicotinonitrile-derived apoptotic inducers: Design, synthesis, X-ray crystal structure and Pim kinase inhibition.

H. Aoyama, Haytham O. Tawfik, Shaimaa M Aboukhatwa, 2022, Bioorganic chemistry.

Discovery of new carbonic anhydrase IX inhibitors as anticancer agents by toning the hydrophobic and hydrophilic rims of the active site to encounter the dual-tail approach.

C. Supuran, Haytham O. Tawfik, A. Petreni, 2022, European journal of medicinal chemistry.

Terminators or Guardians? Design, Synthesis, and Cytotoxicity Profiling of Chalcone-Sulfonamide Hybrids

C. Supuran, A. Angeli, Haytham O. Tawfik, 2023, ACS omega.

Discovery of new symmetrical and asymmetrical nitrile-containing 1,4-dihydropyridine derivatives as dual kinases and P-glycoprotein inhibitors: synthesis, in vitro assays, and in silico studies

A. Belal, Ahmed B. M. Mehany, Haytham O. Tawfik, 2022, Journal of enzyme inhibition and medicinal chemistry.

Novel 4-(2-arylidenehydrazineyl)thienopyrimidine derivatives as anticancer EGFR inhibitors: Design, synthesis, biological evaluation, kinome selectivity and in silico insights.

Wagdy M. Eldehna, E. F. Khaleel, R. Badi, 2023, Bioorganic chemistry.

Recruitment of hexahydroquinoline as anticancer scaffold targeting inhibition of wild and mutants EGFR (EGFRWT, EGFRT790M, and EGFRL858R)

Ahmed B. M. Mehany, M. Sugiura, Omeima Abdullah, 2023, Journal of enzyme inhibition and medicinal chemistry.

Design, synthesis, and molecular docking study of new monastrol analogues as kinesin spindle protein inhibitors.

M. H. El-Hamamsy, Haytham O. Tawfik, T. El-Moselhy, 2020, Archiv der Pharmazie.

Design, synthesis, and bioactivity of dihydropyrimidine derivatives as kinesin spindle protein inhibitors.

M. H. El-Hamamsy, Haytham O. Tawfik, T. El-Moselhy, 2019, Bioorganic & medicinal chemistry.

Papaverinol-N-Oxide: A Microbial Biotransformation Product of Papaverine with Potential Antidiabetic and Antiobesity Activity Unveiled with In Silico Screening

Mohamed H. Mahmoud, G. Batiha, Wagdy M. Eldehna, 2023, Molecules.

Dependence on linkers’ flexibility designed for benzenesulfonamides targeting discovery of novel hCA IX inhibitors as potent anticancer agents

C. Supuran, A. Angeli, Alessandro Bonardi, 2022, Journal of enzyme inhibition and medicinal chemistry.

Novel fused imidazotriazines acting as promising top. II inhibitors and apoptotic inducers with greater selectivity against head and neck tumors: Design, synthesis, and biological assessments.

Hamada S. Abulkhair, A. A. Al-karmalawy, Haytham O. Tawfik, 2023, European journal of medicinal chemistry.

Discovery of sulfonamide-tethered isatin derivatives as novel anticancer agents and VEGFR-2 inhibitors

C. Supuran, A. Angeli, Wagdy M. Eldehna, 2023, Journal of enzyme inhibition and medicinal chemistry.

LC-MS/MS metabolomics profiling of Glechoma hederacea L. methanolic extract; in vitro antimicrobial and in vivo with in silico wound healing studies on Staphylococcus aureus infected rat skin wound

T. Nohara, Sally E Abu-Risha, Mona El-Aasr, 2022, Natural product research.

Lead Optimization of BIBR1591 To Improve Its Telomerase Inhibitory Activity: Design and Synthesis of Novel Four Chemical Series with In Silico, In Vitro, and In Vivo Preclinical Assessments.

Ahmed M. El‐Dessouki, Haytham O. Tawfik, Radwan Alnajjar, 2023, Journal of medicinal chemistry.

Discovery and Mechanistic Studies of Dual-Target Hits for Carbonic Anhydrase IX and VEGFR-2 as Potential Agents for Solid Tumors: X-ray, In Vitro, In Vivo, and In Silico Investigations of Coumarin-Based Thiazoles.

C. Supuran, Wagdy M. Eldehna, Ahmed M. El‐Dessouki, 2024, Journal of Medicinal Chemistry.

Discovery of Novel Pyridazine-Tethered Sulfonamides as Carbonic Anhydrase II Inhibitors for the Management of Glaucoma.

C. Supuran, Wagdy M. Eldehna, A. Nocentini, 2024, Journal of medicinal chemistry.

Development of new thieno[2,3-d]pyrimidines as dual EGFR and STAT3 inhibitors endowed with anticancer and pro-apoptotic activities.

Wagdy M. Eldehna, R. Badi, E. El-Bastawissy, 2024, Bioorganic chemistry.

An overview of recent advancements in small molecules suppression of oncogenic signaling of K-RAS: an updated review.

Ahmed Sabt, Wagdy M. Eldehna, E. F. Khaleel, 2024, Molecular diversity.

Evaluating the ability of some natural phenolic acids to target the main protease and AAK1 in SARS COV-2

A. Belal, Heba I. Ghamry, A. El-Mansi, 2023, Scientific reports.