C. Harris

发表

Sulfoximines as potent RORγ inverse agonists.

F. Bihl, E. Thoreau, S. Deret, 2018, Bioorganic & medicinal chemistry letters.

A convenient one-pot synthesis of boroxoles from diboronic acid

L. Tomas, G. Ouvry, J. Fournier, 2017 .

Design of selective PI3Kα inhibitors starting from a promiscuous pan kinase scaffold.

S. Green, B. Barlaam, S. Cosulich, 2015, Bioorganic & medicinal chemistry letters.

Facile synthesis of 7-amino anilinoquinazolines via direct amination of the quinazoline core

J. Kettle, E. Williams, C. Harris, 2005 .

Injectable Self-Healing Hydrogels Based on Boronate Ester Formation between Hyaluronic Acid Partners Modified with Benzoxaborin Derivatives and Saccharides.

R. Auzély-Velty, C. Rome, T. Figueiredo, 2019, Biomacromolecules.

An Efficient Benzoxaborole One‐Pot Synthesis by Silia Cat DPP‐Pd Heterogeneous Catalysis using Diboronic Acid

L. Tomas, C. Harris, G. Lafitte, 2018, Advanced Synthesis & Catalysis.

Squaramides as novel class I and IIB histone deacetylase inhibitors for topical treatment of cutaneous t-cell lymphoma.

F. Joly, R. Morgentin, E. Thoreau, 2018, Bioorganic & medicinal chemistry letters.

Discovery and Characterization of CD12681, a Potent RORγ Inverse Agonist, Preclinical Candidate for the Topical Treatment of Psoriasis

F. Bihl, N. Atrux-Tallau, E. Thoreau, 2018, ChemMedChem.

Synthesis and stability evaluation of novel peptidomimetic Caspase-1 inhibitors for topical application

N. Vanthuyne, L. Hennequin, L. Tomas, 2018, Tetrahedron.

Inhibitors of epidermal growth factor receptor tyrosine kinase: Novel C-5 substituted anilinoquinazolines designed to target the ribose pocket.

Andrew G. Leach, Paul D. Johnson, R. Morgentin, 2006, Bioorganic & medicinal chemistry letters.

Impact of Minor Structural Modifications on Properties of a Series of mTOR Inhibitors.

A. Taddei, E. Thoreau, S. Deret, 2019, ACS medicinal chemistry letters.

Novel 4-anilinoquinazolines with C-6 carbon-linked side chains: synthesis and structure-activity relationship of a series of potent, orally active, EGF receptor tyrosine kinase inhibitors.

Peter D Smith, J. Kendrew, Rebecca P A Ellston, 2006, Bioorganic & medicinal chemistry letters.

Inhibitors of epidermal growth factor receptor tyrosine kinase: Novel C-5 substituted anilinoquinazolines designed to target the ribose pocket.

Paul D. Johnson, R. Morgentin, R. Bradbury, 2006, Bioorganic & medicinal chemistry letters.

Diversity‐Orientated Synthesis of 3,5‐Bis(arylamino)pyrazoles.

S. Degorce, F. Jung, Arnaud Stévenin, 2012 .

Diversity-orientated synthesis of 3,5-bis(arylamino)pyrazoles

S. Degorce, Patrice Koza, Sébastien L. Degorce, 2011 .

Discovery and process development of a novel TACE inhibitor for the topical treatment of psoriasis.

B. Déprez, L. Hennequin, F. Hacini-Rachinel, 2017, Bioorganic & medicinal chemistry.

Preparation of 6-aminoquinazolin-4(3H)-ones via direct SNAr on the quinazoline ring

B. Barlaam, C. Harris, H. Nguyen, 2012 .

Facile preparation of alkoxybenzoxazoles via direct SNAr on the benzoxazole ring

C. Harris, Nicolas Warin, Hervé Germain, 2010 .

Discovery and application of iminotriphenylphosphorane as a formal aromatic primary amine protecting group

Anaïs F. M. Noisier, G. Ouvry, Honorine Lebraud, 2012 .

Facile, diversity-orientated one-pot synthesis of ethyl 1,5-disubstituted-1H-1,2,4-triazole-3-carboxylates

Paul R. J. Davey, S. Degorce, G. Ouvry, 2012 .

Completion of the impurity profile of lymecycline: Formal identification of impurities E and F.

Thibaud Gerfaud, C. Harris, Romain Pierre, 2022, Journal of pharmaceutical and biomedical analysis.

N-3 alkylation of uracils with unprotected amino alcohols using the Mitsunobu reaction

L. Tomas, J. Fournier, C. Bouix-Peter, 2018 .

Novel preparation of chiral α-amino acids using the Mitsunobu-Tsunoda reaction.

M. Brimble, Anaïs F. M. Noisier, C. Harris, 2013, Chemical communications.

Selective alkylation of a 6,7-dihydroxyquinazoline

L. Hennequin, J. Kettle, C. Harris, 2005 .

Fischer synthesis of isomeric thienopyrrole LHRH antagonists

D. M. Andrews, K. Foote, C. Harris, 2009 .

Synthesis and structure-activity relationships of thieno[2,3-b]pyrroles as antagonists of the GnRH receptor.

Urs J Hancox, K. Foote, C. Harris, 2007, Bioorganic & medicinal chemistry letters.

An expedient synthesis of non-racemic N-alkylated pyrrolidin-2,5-diones and piperidin-2,6-diones as peptidomimetics

D. Roche, C. Lardy, J. Fournier, 2016 .

A facile and rapid preparation of hydroxamic acids by hydroxylaminolysis using DBU as base

L. Tomas, G. Ouvry, Yushma Bhurruth-Alcor, 2016 .

Boronic acid and diol-containing polymers: how to choose the correct couple to form "strong" hydrogels at physiological pH.

R. Auzély-Velty, T. Figueiredo, Vanina A. Cosenza, 2020, Soft matter.

An efficient multi-component synthesis of N-1-alkylated 5-nitrouracils from α-amino acids

Kenny Mebrouk, L. Tomas, J. Fournier, 2016 .

An Efficient Multi-Component Synthesis of N-1-Alkylated 5-Nitrouracils from α-Amino Acids.

C. Harris, 2016 .

Structure-activity relationship of a series of non peptidic RGD integrin antagonists targeting α5β1: part 2.

S. Barry, J. Kendrew, D. Cross, 2012, Bioorganic & medicinal chemistry letters.

Inhibitors of epidermal growth factor receptor tyrosine kinase: optimisation of potency and in vivo pharmacokinetics.

J. Kendrew, R. Bradbury, P. Ballard, 2006, Bioorganic & medicinal chemistry letters.

Efficient Large-Scale Synthesis of Boc-L-azatyrosine

C. Harris, Nicolas Warin, Fabrice Renaud, 2009 .

Efficient three-step one-pot synthesis of a novel 2,3,5-substituted pyrazine library.

L. Hennequin, C. Harris, C. Lambert-van der Brempt, 2011, ACS combinatorial science.

One-pot synthesis of bis(amino)-1,2,4-thiadiazoles via direct SNAr

S. Degorce, R. Morgentin, H. Beeley, 2013 .

Discovery of 1-(4-(5-(5-amino-6-(5-tert-butyl-1,3,4-oxadiazol-2-yl)pyrazin-2-yl)-1-ethyl-1,2,4-triazol-3-yl)piperidin-1-yl)-3-hydroxypropan-1-one (AZD8835): A potent and selective inhibitor of PI3Kα and PI3Kδ for the treatment of cancers.

S. Green, Rebecca P A Ellston, B. Barlaam, 2015, Bioorganic & medicinal chemistry letters.

Discovery of a novel aminopyrazine series as selective PI3Kα inhibitors.

S. Green, B. Barlaam, S. Cosulich, 2017, Bioorganic & medicinal chemistry letters.

Rapid and Selective Cleavage of Amide Groups at Neutral pH: Applications from Hyaluronic Acid to Small Molecules

A. Rousseau, A. Karlsson, L. Nord, 2018, European Journal of Organic Chemistry.

Identification of novel TACE inhibitors compatible with topical application.

B. Déprez, L. Hennequin, F. Hacini-Rachinel, 2017, Bioorganic & medicinal chemistry letters.

Identification of 1,5,7-Triazabicyclododecene and Polystyrene-Supported Superbases as Efficient Hydroxylaminolysis Agents of Sterically Hindered and Epimerizable Esters

L. Tomas, G. Ouvry, C. Harris, 2018, Synlett.

Self-crosslinking smart hydrogels through direct complexation between benzoxaborole derivatives and diols from hyaluronic acid

R. Auzély-Velty, T. Figueiredo, Vanina A. Cosenza, 2020 .

A Convenient Method for the Asymmetric Synthesis of Fluorinated α‐Amino Acids from Alcohols

M. Brimble, Daniel P. Furkert, F. Drouet, 2014 .

Rational Drug Design of Topically Administered Caspase 1 Inhibitors for the Treatment of Inflammatory Acne.

E. Thoreau, L. Chantalat, Kenny Mebrouk, 2018, Journal of Medicinal Chemistry.

Discovery of phenoxyindazoles and phenylthioindazoles as RORγ inverse agonists.

E. Thoreau, L. Chantalat, G. Ouvry, 2016, Bioorganic & medicinal chemistry letters.

New Caspase-1 inhibitor by scaffold hopping into bio-inspired 3D-fragment space.

E. Thoreau, L. Chantalat, M. Gastreich, 2017, Bioorganic & medicinal chemistry letters.

Facile preparation and Suzuki–Miyaura cross-coupling of N-2-alkylated 2H-1,2,3-triazole 4-boronates

Paul R. J. Davey, Thomas Tricotet, G. Ouvry, 2012 .

Novel synthesis of C-3-(hetero)aryl [1,2,3]triazolo[1,5-a]pyridines using the Stille reaction

Honorine Lebraud, C. Harris, Hervé Germain, 2011 .

Abstract 2830: Discovery of AZD8835, a potent and selective inhibitor of PI3Kα and PI3Kδ for the treatment ofPIK3CA-dependent cancers

S. Green, R. Morgentin, S. Cosulich, 2015 .

Three-point variation of a gefinitib quinazoline core

L. Hennequin, C. Harris, Olivier A. Willerval, 2009 .

Facile preparation of thiophene C2-ethers using the Mitsunobu reaction

C. Harris, G. Pasquet, Hervé Germain, 2008 .