M. Keenan

发表

Two Analogues of Fenarimol Show Curative Activity in an Experimental Model of Chagas Disease

David M. Shackleford, M. J. Abbott, Paul W. Alexander, 2013, Journal of medicinal chemistry.

Designing Drugs to Target Trypanosoma cruzi , the Etiological Agent of Chagas Disease: When Chemistry needs Biology

E. Chatelain, M. Keenan, 2019, Neglected Tropical Diseases.

T. cruzi CYP51 complexes with UDO and UDD Complexes of Trypanosoma cruzi sterol 14a-demethylase (CYP51) with two pyridine-based drug candidates for Chagas disease: Structural basis for pathogen-selectivity*

Paul W. Alexander, M. Waterman, Z. Wawrzak, 2013 .

Complexes of Trypanosoma cruzi Sterol 14α-Demethylase (CYP51) with Two Pyridine-based Drug Candidates for Chagas Disease

Paul W. Alexander, M. Waterman, Z. Wawrzak, 2013, The Journal of Biological Chemistry.

Enantioselective Heck reactions using chiral P,N-ligands

M. Hayashi, O. Loiseleur, A. Pfaltz, 1999 .

Design, structure-activity relationship and in vivo efficacy of piperazine analogues of fenarimol as inhibitors of Trypanosoma cruzi.

David M. Shackleford, Paul W. Alexander, E. Chatelain, 2013, Bioorganic & medicinal chemistry.

Analogues of fenarimol are potent inhibitors of Trypanosoma cruzi and are efficacious in a murine model of Chagas disease.

M. J. Abbott, Paul W. Alexander, E. Chatelain, 2012, Journal of medicinal chemistry.

A Suzuki Coupling Approach to Pyrazines Related to Coelenterazine

Keith Jones, F. Hibbert, M. Keenan, 1996 .

Synthesis of versatile chiral N,P ligands derived from pyridine and quinoline.

M. Hayashi, R. Goddard, W. Drury, 2004, Angewandte Chemie.

Highly efficient and flexible total synthesis of coelenterazine

Keith Jones, F. Hibbert, M. Keenan, 1997 .

Bicyclo[2.2.1]heptanes as novel triple re-uptake inhibitors for the treatment of depression.

J. Boot, D. Tupper, S. Milutinovic, 2003, Bioorganic & medicinal chemistry letters.

New facile and mild synthesis of 2-substituted oxazolopyridines

M. Keenan, A. Weichert, S. Heuser, 2005 .

Addition of lithiated tertiary aromatic amides to epoxides and;aziridines: Asymmetric synthesis of (S)-(+)-mellein

M. Helliwell, C. Stimson, J. Clayden, 2006 .

The regioselective aminohydroxylation of allylic carbamates.

T. Donohoe, P. Johnson, M. Helliwell, 2001, Chemical communications.

Concise and enantioselective synthesis of the aminocyclitol core of hygromycin A.

R. Pye, T. Donohoe, P. Johnson, 2005, Organic letters.

Synthesis of versatile chiral N,P ligands derived from pyridine and quinoline.

M. Hayashi, R. Goddard, W. Drury, 2004, Angewandte Chemie.

Synthesis of pyridine fused polycyclic amines using sequential ring-closing metathesis and radical cyclisation reactions

Richard A. Lewis, M. Keenan, S. R. Baker, 2003 .

Contra-Friedel-Crafts tert-butylation of substituted aromatic rings via directed metallation and sulfinylation.

C. Stimson, J. Clayden, M. Keenan, 2006, Chemical communications.

Fast racemisation and slow epimerisation of laterally lithiated amides: stereochemical evidence for the mechanism of inversion of amide-substituted benzyllithiums.

A. Wheatley, C. Stimson, J. Clayden, 2004, Chemical communications.

HIGHLY EFFICIENCY AND FLEXIBLE TOTAL SYNTHESIS OF COELENTERAZINE

Keith Jones, F. Hibbert, M. Keenan, 1997 .

A new era for chagas disease drug discovery?

M. Keenan, J. Chaplin, 2015, Progress in medicinal chemistry.

The tethered aminohydroxylation (TA) of cyclic allylic carbamates.

T. Donohoe, A. Cowley, P. Johnson, 2002, Journal of the American Chemical Society.

Re-evaluating pretomanid analogues for Chagas disease: Hit-to-lead studies reveal both in vitro and in vivo trypanocidal efficacy.

K. Read, W. Denny, A. M. Thompson, 2020, European journal of medicinal chemistry.

A Suzuki Coupling Approach to Pyrazines Related to Coelenterazine.

Keith Jones, F. Hibbert, M. Keenan, 1996 .

Glowing jellyfish, luminescence and a molecule called coelenterazine.

K Jones, F Hibbert, M Keenan, 1999, Trends in biotechnology.

Selection and optimization of hits from a high-throughput phenotypic screen against Trypanosoma cruzi.

M. J. Abbott, Paul W. Alexander, S. Cornwall, 2013, Future medicinal chemistry.

Boron-based drugs as antiprotozoals

J. Plattner, R. Jacobs, M. Keenan, 2011, Current opinion in infectious diseases.

Asymmetric Ortholithiation of Amides by Conformationally Mediated Chiral Memory: An Enantioselective Route to Naphtho- and Benzofuranones

C. Stimson, J. Clayden, M. Keenan, 2005 .

Allosteric Potentiators of Neuronal Nicotinic Cholinergic Receptors: Potential Treatments for Neurodegenerative Disorders

E. Sher, L. Wallace, L. Broad, 2008 .

Recent progress in the development of subtype selective nicotinic acetylcholine receptor ligands.

J. Boot, L. Broad, P. Astles, 2002, Current drug targets. CNS and neurological disorders.

PSAB-OFP, a selective alpha 7 nicotinic receptor agonist, is also a potent agonist of the 5-HT3 receptor.

E. Sher, L. Wallace, J. Boot, 2002, European journal of pharmacology.

High affinity ligands for the alpha7 nicotinic receptor that show no cross-reactivity with the 5-HT3 receptor.

L. Wallace, J. Boot, D. Dobson, 2005, Bioorganic & medicinal chemistry letters.

Selection and optimization of hits from a high-throughput phenotypic screen against Trypanosoma cruzi.

Paul W. Alexander, E. Chatelain, S. Charman, 2013, Future medicinal chemistry.