Maria Musgaard

发表

Insights into channel dysfunction from modelling and molecular dynamics simulations

P. Biggin, T. Paramo, Laura Domicevica, 2017, Neuropharmacology.

The dynamics of camphor in the cytochrome P450 CYP101D2

P. Biggin, S. Bell, L. Wong, 2013, Protein science : a publication of the Protein Society.

Coupling structure with function in acid‐sensing ion channels: challenges in pursuit of proton sensors

David M. Maclean, Maria Musgaard, M. Rook, 2020, The Journal of physiology.

Promiscuous attraction of ligands within the ATP binding site of RyR2 promotes diverse gating behaviour

E. Venturi, R. Sitsapesan, W. Welch, 2018, Scientific Reports.

Kainate receptor pore‐forming and auxiliary subunits regulate channel block by a novel mechanism

P. Biggin, D. Bowie, Patricia M G E Brown, 2016, The Journal of physiology.

Identification and functional evaluation of GRIA1 missense and truncation variants in individuals with ID: An emerging neurodevelopmental syndrome

Matthew O. Parker, D. Baralle, S. Ellard, 2022, American journal of human genetics.

Mutational Analysis and Modeling of Negative Allosteric Modulator Binding Sites in AMPA Receptors

A. Kristensen, Maria Musgaard, Sergei Chavez-Abiega, 2019, Molecular Pharmacology.

Statin activation of skeletal ryanodine receptors (RyR1) is a class effect but separable from HMG‐CoA reductase inhibition

R. Sitsapesan, A. Russell, Maria Musgaard, 2022, British Journal of Pharmacology.

A dynamically interacting flexible loop assists oligomerisation of the Caenorhabditis elegans centriolar protein SAS-6

M. Erat, P. Biggin, I. Vakonakis, 2019, Scientific Reports.

Mutation of a conserved Gln residue does not abolish desensitization of acid-sensing ion channel 1

David M. Maclean, Tyler Couch, Maria Musgaard, 2020, bioRxiv.

Statin activation of skeletal ryanodine receptors (RyR1) is a class effect but separable from HMG‐CoA reductase inhibition

R. Sitsapesan, A. Russell, Maria Musgaard, 2021, British journal of pharmacology.

Ion Pathways in the Sarcoplasmic Reticulum Ca2+-ATPase*

P. Nissen, J. P. Morth, B. Schiøtt, 2013, The Journal of Biological Chemistry.

Ion Pathways in the Sarcoplasmic Reticulum

P. Nissen, J. P. Morth, B. Schiøtt, 2013 .

A single historical substitution drives an increase in acetylcholine receptor complexity

K. Burkett, Gregory D. McCluskey, Maria Musgaard, 2021, Proceedings of the National Academy of Sciences.

P-type ATPases as drug targets: tools for medicine and science.

P. Nissen, J. P. Morth, M. Palmgren, 2009, Biochimica et biophysica acta.

Mutation of a conserved glutamine residue does not abolish desensitization of acid-sensing ion channel 1

David M. Maclean, Tyler Couch, Maria Musgaard, 2021, The Journal of general physiology.

β11-12 linker isomerization governs acid-sensing ion channel desensitization and recovery

J. Lueck, David M. Maclean, Maria Musgaard, 2019, bioRxiv.

Actions of Agonists, Fipronil and Ivermectin on the Predominant In Vivo Splice and Edit Variant (RDLbd, I/V) of the Drosophila GABA Receptor Expressed in Xenopus laevis Oocytes

S. Buckingham, D. Sattelle, P. Biggin, 2014, PloS one.

Identification of compounds that bind the centriolar protein SAS-6 and inhibit its oligomerization

P. Biggin, I. Vakonakis, G. Spyroulias, 2020, The Journal of Biological Chemistry.

Binding and Orientation of Tricyclic Antidepressants within the Central Substrate Site of the Human Serotonin Transporter*

L. Çelik, S. Sinning, K. Severinsen, 2009, The Journal of Biological Chemistry.

The V2475F CPVT1 mutation yields distinct RyR2 channel populations that differ in their responses to cytosolic Ca2+ and Mg2+

C. Valdivia, E. Venturi, R. Sitsapesan, 2021, The Journal of physiology.

Promiscuous attraction of ligands within the ATP binding site of RyR2 promotes diverse gating behaviour

E. Venturi, R. Sitsapesan, W. Welch, 2018, Scientific Reports.

Tracing cytoplasmic Ca(2+) ion and water access points in the Ca(2+)-ATPase.

E. Tajkhorshid, B. Schiøtt, Lea Thøgersen, 2012, Biophysical journal.

MD Simulations of P-Type ATPases in a Lipid Bilayer System.

Maria Musgaard, Henriette Elisabeth Autzen, Maria Musgaard, 2016, Methods in molecular biology.

Mutual adaptation of a membrane protein and its lipid bilayer during conformational changes.

P. Nissen, B. Schiøtt, J. Møller, 2011, Nature communications.

Distinct Structural Pathways Coordinate the Activation of AMPA Receptor-Auxiliary Subunit Complexes

P. Biggin, N. Nayeem, T. Green, 2016, Neuron.

Functional Validation of Heteromeric Kainate Receptor Models.

P. Biggin, D. Bowie, T. Paramo, 2017, Biophysical journal.

Steered Molecular Dynamics Simulations Predict Conformational Stability of Glutamate Receptors

Maria Musgaard, Philip C. Biggin, P. Biggin, 2016, J. Chem. Inf. Model..

Defining the structural relationship between kainate receptor deactivation and desensitization

P. Biggin, D. Bowie, Bryan A. Daniels, 2013, Nature Structural &Molecular Biology.

Protonation states of important acidic residues in the central Ca²⁺ ion binding sites of the Ca²⁺-ATPase: a molecular modeling study.

B. Schiøtt, Lea Thøgersen, Maria Musgaard, 2011, Biochemistry.

Role of the Cys Loop and Transmembrane Domain in the Allosteric Modulation of α4β2 Nicotinic Acetylcholine Receptors*

P. Biggin, P. Iturriaga-Vásquez, I. Bermúdez, 2016, The Journal of Biological Chemistry.

Molecular Investigation of Chicken Acid-Sensing Ion Channel 1 β11-12 Linker Isomerization and Channel Kinetics

David M. Maclean, Maria Musgaard, M. Rook, 2021, Frontiers in Cellular Neuroscience.

A dynamically interacting flexible loop assists oligomerisation of the Caenorhabditis elegans centriolar protein SAS-6

M. Erat, P. Biggin, I. Vakonakis, 2019, Scientific Reports.

Distinct Structural Pathwa ys Coordinate the Activation of AMPA Receptor-Auxiliary Subunit Complexes Highlights

P. Biggin, N. Nayeem, T. Green, 2016 .

Multiscale molecular dynamics simulations predict arachidonic acid binding sites in human ASIC1a and ASIC3 transmembrane domains

Maria Musgaard, Anna Ananchenko, 2023, The Journal of general physiology.

Binding and Orientation of Tricyclic Antidepressants within the Central Substrate Site of the Human Serotonin Transporter*

L. Çelik, S. Sinning, K. Severinsen, 2009, The Journal of Biological Chemistry.

Small molecule positive allosteric modulation of homomeric kainate receptors GluK1-3: Development of screening assays and insight into GluK3 structure

P. Biggin, J. Kastrup, M. Gajhede, 2023, bioRxiv.

Statin activation of skeletal ryanodine receptors (RyR1) is a class effect but separable from HMG‐CoA reductase inhibition

R. Sitsapesan, A. Russell, Maria Musgaard, 2022, British journal of pharmacology.