P. Ciaccio

发表

cDNA and deduced amino acid sequences of a human colon dihydrodiol dehydrogenase.

K. Tew, P. Ciaccio, 1994, Biochimica et biophysica acta.

Optimization of physicochemical properties and safety profile of novel bacterial topoisomerase type II inhibitors (NBTIs) with activity against Pseudomonas aeruginosa.

T. Dougherty, Liang Zhao, C. Eyermann, 2014, Bioorganic & medicinal chemistry.

Cellular and in vitro transport of glutathione conjugates by MRP.

K. Tew, G. Kruh, N. Laing, 1996, Biochemistry.

Modulation of detoxification gene expression in human colon HT29 cells by glutathione-S-transferase inhibitors.

M. Lyttle, K. Tew, A. Jaiswal, 1995, Molecular pharmacology.

The spontaneous and glutathione S-transferase-mediated reaction of chlorambucil with glutathione.

K. Tew, F. LaCreta, P. Ciaccio, 1990, Cancer communications.

Regulation of human dihydrodiol dehydrogenase by Michael acceptor xenobiotics.

K. Tew, A. Jaiswal, P. Ciaccio, 1994, The Journal of biological chemistry.

Overproduction of a 37.5-kDa cytosolic protein structurally related to prostaglandin F synthase in ethacrynic acid-resistant human colon cells.

K. Tew, P. Ciaccio, J. Stuart, 1993, Molecular pharmacology.

Characterization of a phenobarbital-inducible dog liver cytochrome P450 structurally related to rat and human enzymes of the P450IIIA (steroid-inducible) gene subfamily.

J. Halpert, P. Ciaccio, Paul J. Ciaccio, 1989, Archives of biochemistry and biophysics.

Optimization of brain-penetrant picolinamide derived leucine-rich repeat kinase 2 (LRRK2) inhibitors.

Karin M. Otte, G. Morriello, B. Pio, 2021, RSC medicinal chemistry.

Adaptive response to glutathione S-transferase inhibitors.

K. Tew, P. Ciaccio, Kenneth D. Tew, 1996, The British journal of cancer. Supplement.

Isozyme-specific glutathione S-transferase inhibitors potentiate drug sensitivity in cultured human tumor cell lines

L. Kauvar, K. Tew, A. Morgan, 1996, Cancer Chemotherapy and Pharmacology.

cDNA and deduced amino acid sequences of a dog hepatic cytochrome P450IIB responsible for the metabolism of 2,2',4,4',5,5'-hexachlorobiphenyl.

J. Halpert, P. Graves, P. Ciaccio, 1990, Archives of biochemistry and biophysics.

Characterization of the onset, progression, and reversibility of morphological changes in mouse lung following pharmacological inhibition of LRRK2 kinase activity

Matthew L. Maddess, Karin M. Otte, M. Kennedy, 2021 .

Differential Cytotoxicity Responses by Dog and Rat Hepatocytes to Phospholipogenic Treatments

J. K. Morelli, P. Ciaccio, 2013, Journal of toxicology.

Novel N-linked aminopiperidine inhibitors of bacterial topoisomerase type II with reduced pK(a): antibacterial agents with an improved safety profile.

D. Ehmann, M. Cronin, A. A. Godfrey, 2012, Journal of medicinal chemistry.

cDNA and deduced amino acid sequences of a dog liver cytochrome P-450 of the IIIA gene subfamily.

J. Halpert, P. Graves, B. Glinsmann-Gibson, 1991, Biochimica et biophysica acta.

Validation of an in vitro screen for phospholipidosis using a high-content biology platform

Y-K Lee, F. Pognan, R. Vrzal, 2006, Cell Biology and Toxicology.

Enzymatic conjugation of chlorambucil with glutathione by human glutathione S-transferases and inhibition by ethacrynic acid.

K. Tew, F. LaCreta, P. Ciaccio, 1991, Biochemical pharmacology.

Early prediction of polymyxin-induced nephrotoxicity with next-generation urinary kidney injury biomarkers.

Douglas Ferguson, Patricia Bentley, Gunther Kern, 2014, Toxicological sciences : an official journal of the Society of Toxicology.

Modulation of notch processing by gamma-secretase inhibitors causes intestinal goblet cell metaplasia and induction of genes known to specify gut secretory lineage differentiation.

Francois Pognan, F. Pognan, B. Greenberg, 2004, Toxicological sciences : an official journal of the Society of Toxicology.

Pathology and Neurotoxicity in Dogs after Repeat Dose Exposure to a Serotonin 5-HT1B Inhibitor

P. Schroeder, A. Berg, P. Ciaccio, 2014, Journal of toxicologic pathology.

Detection of in vivo biomarkers of phospholipidosis using NMR‐based metabonomic approaches

John C. Lindon, Jeremy K. Nicholson, Elaine Holmes, 2001 .

Investigation of the positive response of ethyl acrylate in the mouse lymphoma genotoxicity assay.

P. O'Neill, Y. Vandenberghe, P. Ciaccio, 1998, Toxicological sciences : an official journal of the Society of Toxicology.

Genomic sequence of human glyoxalase-I: analysis of promoter activity and its regulation.

K. Tew, E. Walsh, S. Ranganathan, 1999, Gene.

Drug-Induced Phospholipidosis

Peter R. Bernstein, P. Bernstein, Paul Ciaccio, 2011 .

Structure-Guided Discovery of Aminoquinazolines as Brain-Penetrant and Selective LRRK2 Inhibitors.

Michael J. Ardolino, Karin M. Otte, M. Kennedy, 2021, Journal of medicinal chemistry.

The metabolism of xenobiotics and endogenous compounds by the constitutive dog liver cytochrome P450 PBD-2.

D. B. Duignan, J. Halpert, I. Sipes, 1988, Archives of biochemistry and biophysics.

An Evaluation of the Dna Array for Use in Toxicological Studies

L. G. Davis, L. Slusher, Gregory S. Ladies, 2001 .

Discovery and Optimization of Potent, Selective, and Brain-Penetrant 1-Heteroaryl-1H-Indazole LRRK2 Kinase Inhibitors for the Treatment of Parkinson's Disease.

Theodore A. Martinot, Michael J. Ardolino, Matthew L. Maddess, 2022, Journal of medicinal chemistry.

11 – Application of New Technologies to Toxicologic Pathology

B. Car, N. Contel, P. Ciaccio, 2002 .

Selective inactivation by chloramphenicol of the major phenobarbital-inducible isozyme of dog liver cytochrome P-450.

D. B. Duignan, J. Halpert, P. Ciaccio, 1987, Drug metabolism and disposition: the biological fate of chemicals.

Effects of chronic ethacrynic acid exposure on glutathione conjugation and MRP expression in human colon tumor cells.

K. Tew, G. Kruh, H. Shen, 1996, Biochemical and biophysical research communications.

2,6-Disubstituted pyrazines and related analogs as NR2B site antagonists of the NMDA receptor with anti-depressant activity.

Clay W Scott, Magnus J. Johansson, Jennifer R. Krumrine, 2011, Bioorganic & medicinal chemistry letters.

Early-Onset albuminuria and Associated Renal Pathology in Leucine-Rich Repeat Kinase 2 Knockout Rats

Yi-Zhong Gu, Roger J Smith, Rupesh P. Amin, 2023, Toxicologic pathology.

Characterization of the Onset, Progression, and Reversibility of Morphological Changes in Mouse Lung after Pharmacological Inhibition of Leucine-Rich Kinase 2 Kinase Activity

Matthew L. Maddess, Karin M. Otte, M. Kennedy, 2021, The Journal of Pharmacology and Experimental Therapeutics.

Promoter analysis of a human dihydrodiol dehydrogenase.

K. Tew, E. Walsh, P. Ciaccio, 1996, Biochemical and biophysical research communications.

Phospholipogenic Pharmaceuticals Are Associated with a Higher Incidence of Histological Findings than Nonphospholipogenic Pharmaceuticals in Preclinical Toxicology Studies

Scott Boyer, S. Boyer, J. Fikes, 2012, Journal of toxicology.