T. Biftu

发表

Kinetics of the thermal decomposition of pyridine in a flow system

T. Houser, M. Mccarville, T. Biftu, 1980 .

Kinetics of the Thermal Decomposition of Pyridine

T. Biftu, 1975 .

Purification and Molecular Characterization of cGMP-dependent Protein Kinase from Apicomplexan Parasites

Jeffrey Yuan, D. Schmatz, B. Nare, 2002, The Journal of Biological Chemistry.

Discovery of an orally bioavailable alkyl oxadiazole beta3 adrenergic receptor agonist.

R. Miller, C. Strader, D. Macintyre, 2000, Bioorganic & medicinal chemistry letters.

(3R)-4-[(3R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoyl]-3-(2,2,2-trifluoroethyl)-1,4-diazepan-2-one, a selective dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes.

G. Scapin, Suresh B. Singh, N. Thornberry, 2007, Bioorganic & medicinal chemistry letters.

Optimization of 1,4-diazepan-2-one containing dipeptidyl peptidase IV inhibitors for the treatment of type 2 diabetes.

N. Thornberry, B. Leiting, G. Eiermann, 2007, Bioorganic & medicinal chemistry letters.

Epibatidine is a nicotinic analgesic.

J. Eckman, C. Qian, T. Shen, 1993, European journal of pharmacology.

Novel tetrahydropyran analogs as dipeptidyl peptidase IV inhibitors: Profile of clinical candidate (2R,3S,5R)-2- (2,5-difluorophenyl)-5-(4,6-dihydropyrrolo [3,4-c]pyrazol-5-(1H)-yl)tetrahydro-2H-pyran-3-amine (23) [corrected].

Ping Chen, G. Scapin, R. S. Roy, 2013, Bioorganic & medicinal chemistry letters.

trans-2,5-Bis-(3,4,5-trimethoxyphenyl)tetrahydrofuran. An orally active specific and competitive receptor antagonist of platelet activating factor.

S. Hwang, M. Lam, T. Shen, 1985, The Journal of biological chemistry.

Structure-activity-relationship of amide and sulfonamide analogs of omarigliptin.

Youwei Yan, Ping Chen, J. Metzger, 2015, Bioorganic & medicinal chemistry letters.

Synthesis and biological activity of MK 287(L-680, 573) a potent specific and orally active PAF receptor antagonist.

Margaret S. Wu, T. Doebber, D. Macintyre, 1991 .

(+/-)-trans-2-(3-Methoxy-5-methylsulfonyl-4-propoxyphenyl)-5-(3,4,5- trimethoxyphenyl)tetrahydrofuran (L-659,989), a novel, potent PAF receptor antagonist.

T. Doebber, A. Alberts, J. C. Chabala, 1988, Biochemical and biophysical research communications.

Platelet-activating factor (PAF) mediation of rat anaphylactic responses to soluble immune complexes. Studies with PAF receptor antagonist L-652,731.

M. Wu, T. Doebber, T. Biftu, 1986, Journal of immunology.

Lead Optimization to Advance Protease-Activated Receptor-1 Antagonists in Early Discovery.

Walter A. Korfmacher, W. Greenlee, A. Cheng, 2022, Journal of medicinal chemistry.

Natural 2,5‐bisaryltetrahydrofuran lignans: Platelet‐activating factor antagonists

T. Biftu, R. Stevenson, 1987 .

Synthesis and biological activity of imidazopyridine anticoccidial agents: Part II.

D. Schmatz, P. Liberator, M. Fisher, 2007, European journal of medicinal chemistry.

A synthetic pseudolignan derivative as potent and specific PAF-acether receptor antagonist

Margaret S. Wu, T. Doebber, S. Hwang, 1985 .

Development, synthesis, and biological evaluation of (-)-trans-(2S,5S)-2-[3-[(2-oxopropyl)sulfonyl]-4-n-propoxy-5-(3- hydroxypropoxy)-phenyl]-5-(3,4,5-trimethoxyphenyl)tetrahydrofuran, a potent orally active platelet-activating factor (PAF) antagonist and its water-soluble prodrug phosphate ester.

T. Bach, A. Alberts, J. C. Chabala, 1992, Journal of medicinal chemistry.

Synthesis and SAR studies of very potent imidazopyridine antiprotozoal agents.

D. Schmatz, P. Liberator, M. Fisher, 2006, Bioorganic & medicinal chemistry letters.

Synthesis and biological activity of anticoccidial agents: 5,6-diarylimidazo[2,1-b][1,3]thiazoles.

D. Schmatz, P. Liberator, M. Fisher, 2008, Bioorganic & medicinal chemistry letters.

N-alkyl-4-piperidinyl-2,3-diarylpyrrole derivatives with heterocyclic substitutions as potent and broad spectrum anticoccidial agents.

D. Schmatz, P. Liberator, M. Fisher, 2008, Bioorganic & medicinal chemistry letters.

Synthesis and SAR of benzyl and phenoxymethylene oxadiazole benzenesulfonamides as selective beta3 adrenergic receptor agonist antiobesity agents.

C. Strader, D. Macintyre, M. Forrest, 2000, Bioorganic & medicinal chemistry letters.

Heterocyclic core analogs of a direct thrombin inhibitor.

A. Crespo, J. Wiltsie, M. Kurtz, 2014, Bioorganic & medicinal chemistry letters.

DETERMINATION OF PUNGENCY DUE TO CAPSICUM BY GAS‐LIQUID CHROMATOGRAPHY

T. Biftu, P. Todd, M. Bensinger, 1977 .

TLC screening techniques for the qualitative determination of natural and synthetic capsaicinoids.

T. Biftu, P. Todd, M. Bensinger, 1975, Journal of chromatographic science.

Syntheses and analgesic/antiinflammatory activities of novel 2-|5-aroyl pyrrolo|alkanoic acids

R. Zambias, M. Goldenberg, P. Bailey, 1987 .

Synthesis and SAR studies of potent imidazopyridine anticoccidial agents.

D. Schmatz, P. Liberator, M. Fisher, 2007, Bioorganic & medicinal chemistry letters.

Synthesis and SAR of 2-(4-fluorophenyl)-3-pyrimidin-4-ylimidazo[1,2-a]pyridine derivatives as anticoccidial agents.

D. Schmatz, P. Liberator, M. Fisher, 2006, Bioorganic & medicinal chemistry letters.

Dipeptidyl peptidase IV inhibition for the treatment of type 2 diabetes: potential importance of selectivity over dipeptidyl peptidases 8 and 9.

A. Woods, D. Zaller, N. Thornberry, 2005, Diabetes.

Hydroxylated N-alkyl-4-piperidinyl-2,3-diarylpyrrole derivatives as potent broad-spectrum anticoccidial agents.

D. Schmatz, P. Liberator, M. Fisher, 2005, Bioorganic & medicinal chemistry letters.

Synthesis and SAR of 2,3-diarylpyrrole inhibitors of parasite cGMP-dependent protein kinase as novel anticoccidial agents.

D. Schmatz, P. Liberator, M. Fisher, 2005, Bioorganic & medicinal chemistry letters.

Omarigliptin (MK-3102): a novel long-acting DPP-4 inhibitor for once-weekly treatment of type 2 diabetes.

Kathy Lyons, Ping Chen, Dennis Feng, 2014, Journal of medicinal chemistry.

DPP-4 Inhibitors

R. Sinharoy, T. Biftu, 2017 .

Systemic pan-AMPK activator MK-8722 improves glucose homeostasis but induces cardiac hypertrophy

M. Erion, D. Kemp, S. Prahalada, 2017, Science.

Diminishing GSH-Adduct Formation of Tricyclic Diazepine-based Mutant IDH1 Inhibitors.

Matthew L. Maddess, Y. Liu, X. Fradera, 2022, ACS medicinal chemistry letters.

Synthesis and SAR studies of diarylpyrrole anticoccidial agents.

D. Schmatz, P. Liberator, M. Fisher, 2006, Bioorganic & medicinal chemistry letters.

Pharmacological AMPK activation induces transcriptional responses congruent to exercise in skeletal and cardiac muscle, adipose tissues and liver

M. Erion, D. Kemp, S. Souza, 2019, PloS one.

Conformation and activity of tetrahydrofuran lignans and analogues as specific platelet activating factor antagonists.

J. Snyder, J. Springer, T. Doebber, 1986, Journal of medicinal chemistry.

Omarigliptin (MARIZEV™, MK‐3102)

T. Biftu, 2018 .

Discovery of MK-8722: A Systemic, Direct Pan-Activator of AMP-Activated Protein Kinase.

D. Kemp, Gaochao Zhou, F. A. Romero, 2018, ACS medicinal chemistry letters.

The discovery of novel 5,6,5- and 5,5,6-tricyclic pyrrolidines as potent and selective DPP-4 inhibitors.

J. Metzger, G. Scapin, S. Xu, 2016, Bioorganic & medicinal chemistry letters.

Synthesis and biological activity of imidazopyridine anticoccidial agents: part I.

D. Schmatz, P. Liberator, M. Fisher, 2007, European journal of medicinal chemistry.

Synthesis and biological activity of anticoccidial agents: 2,3-diarylindoles.

D. Schmatz, P. Liberator, M. Fisher, 2009, Bioorganic & Medicinal Chemistry Letters.

Discovery of new binding elements in DPP-4 inhibition and their applications in novel DPP-4 inhibitor design.

G. Scapin, Suresh B. Singh, N. Thornberry, 2008, Bioorganic & medicinal chemistry letters.

Modeling assisted rational design of novel, potent, and selective pyrrolopyrimidine DPP-4 inhibitors.

R. Sheridan, G. Scapin, N. Thornberry, 2007, Bioorganic & medicinal chemistry letters.

Improved Stability of Proline-Derived Direct Thrombin Inhibitors through Hydroxyl to Heterocycle Replacement.

L. Mitnaul, B. Hawes, K. O'neill, 2015, ACS medicinal chemistry letters.

Rational design of a novel, potent, and orally bioavailable cyclohexylamine DPP-4 inhibitor by application of molecular modeling and X-ray crystallography of sitagliptin.

G. Scapin, Suresh B. Singh, N. Thornberry, 2007, Bioorganic & medicinal chemistry letters.

Selective protection and relative importance of the carboxylic acid groups of zaragozic acid A for squalene synthase inhibition.

K. Wilson, R. Marquis, W. Parsons, 1994, Journal of medicinal chemistry.

Selective Protection and Relative Importance of the Carboxylic Acid Groups of Zargozic Acid A for Squalene Synthase Inhibition.

K. Wilson, R. Marquis, W. Parsons, 1994 .

Zaragozic acid A, a potent inhibitor of squalene synthase: initial chemistry and absolute stereochemistry

K. Wilson, R. Ball, K. Hoogsteen, 1992 .

Diesters of zaragozic acid A: Synthesis and biological activity

R. Marquis, G. Doss, M. Kurtz, 1993 .