D. Luci

发表

PLATELETS AND THROMBOPOIESIS Platelet 12-LOX is essential for Fc g RIIa-mediated platelet activation

A. Jadhav, A. Simeonov, T. Holman, 2014 .

Pyrimidinopyrimidine inhibitors of ketohexokinase: exploring the ring C2 group that interacts with Asp-27B in the ligand binding pocket.

A. Gibbs, M. Connelly, D. McComsey, 2012, Bioorganic & medicinal chemistry letters.

12-Lipoxygenase Inhibitor Improves Functions of Cytokine-Treated Human Islets and Type 2 Diabetic Islets

S. H. Park, D. Maloney, R. Mirmira, 2017, The Journal of clinical endocrinology and metabolism.

Generation of novel, potent urotensin-II receptor antagonists by alkylation-cyclization of isoindolinone C3-carbanions

B. Maryanoff, L. Minor, W. Kinney, 2009 .

Synthesis and biological evaluation of a targeted library of protein phosphatase inhibitors.

P. Wipf, J. Lazo, E. Southwick, 2000, Biotechnology and bioengineering.

Discovery of ML355, a Potent and Selective Inhibitor of Human 12-Lipoxygenase

Adam Yasgar, A. Jadhav, A. Simeonov, 2014 .

Structure-Function Study of Quinazolinone-Based Vitronectin Receptor (αVβ3) Antagonists: Computer-Assisted Analysis of Ligand-Receptor Interactions

B. Tounge, M. J. Costanzo, W. Kinney, 2004 .

The Heck reaction with unprotected allylic amidines and guanidines

D. Wisnoski, B. Maryanoff, W. Kinney, 2002 .

Nonpeptide urotensin-II receptor antagonists: a new ligand class based on piperazino-phthalimide and piperazino-isoindolinone subunits.

C. Reynolds, B. Maryanoff, B. Damiano, 2009, Journal of medicinal chemistry.

Irreversible inhibition of cytosolic thioredoxin reductase 1 as a mechanistic basis for anticancer therapy

Anton Simeonov, Ajit Jadhav, Owe Orwar, 2018, Science Translational Medicine.

A selective USP1-UAF1 inhibitor links deubiquitination to DNA damage responses.

Anton Simeonov, Ping Zhang, Ajit Jadhav, 2014, Nature chemical biology.

Synthesis and Structure−Activity Relationship Studies of N‐Benzyl-2- phenylpyrimidin-4-amine Derivatives as Potent USP1/UAF1 Deubiquitinase Inhibitors with Anticancer Activity against Nonsmall Cell Lung Cancer

A. Jadhav, Hongmao Sun, A. Simeonov, 2014 .

Platelet 12-LOX is essential for FcγRIIa-mediated platelet activation.

Anton Simeonov, Ajit Jadhav, Jin Ren, 2014, Blood.

Disrupting malaria parasite AMA1 – RON2 interaction with a small molecule prevents erythrocyte invasion

Anton Simeonov, Xin Hu, Ajit Jadhav, 2013, Nature Communications.

Synthesis and structure-activity relationship studies of 4-((2-hydroxy-3-methoxybenzyl)amino)benzenesulfonamide derivatives as potent and selective inhibitors of 12-lipoxygenase.

Adam Yasgar, A. Jadhav, A. Simeonov, 2014, Journal of medicinal chemistry.

Discovery and Optimization of Potent, Cell-Active Pyrazole-Based Inhibitors of Lactate Dehydrogenase (LDH).

D. Urban, A. Jadhav, C. Dang, 2017, Journal of medicinal chemistry.

First Selective 12-LOX Inhibitor, ML355, Impairs Thrombus Formation and Vessel Occlusion In Vivo With Minimal Effects on Hemostasis

A. Jadhav, A. Simeonov, T. Holman, 2017, Arteriosclerosis, thrombosis, and vascular biology.

A High-Throughput Screen Identifies 2,9-Diazaspiro[5.5]Undecanes as Inducers of the Endoplasmic Reticulum Stress Response with Cytotoxic Activity in 3D Glioma Cell Models

G. Riggins, Adam Yasgar, A. Jadhav, 2016, PloS one.

Inhibitors of Ketohexokinase: Discovery of Pyrimidinopyrimidines with Specific Substitution that Complements the ATP-Binding Site.

A. Gibbs, D. McComsey, B. Maryanoff, 2011, ACS medicinal chemistry letters.

A Concise Synthesis of an Indenopyrrolidine-based Dual avb3/avb5 Integrin Antagonist

B. Tounge, B. Maryanoff, B. Damiano, 2004 .