G. Costello

发表

Discovery of a new class of anilinoquinazoline inhibitors with high affinity and specificity for the tyrosine kinase domain of c-Src.

P. Plé, J. Curwen, L. Hennequin, 2004, Journal of medicinal chemistry.

Structure/activity studies related to 2-(3,4-dichlorophenyl)-N-methyl-N-[2-(1-pyrrolidinyl)-1-substituted- ethyl]acetamides: a novel series of potent and selective kappa-opioid agonists.

T. Blackburn, K. Russell, J. Shaw, 1991, Journal of medicinal chemistry.

The discovery of AZD0530: a novel, oral, highly selective and dual-specific inhibitor of the Src and Abl family kinases

R. Morgentin, P. Plé, L. Hennequin, 2005 .

2-(3,4-Dichlorophenyl)-N-methyl-N-[2-(1-pyrrolidinyl)-1-substituted- ethyl]-acetamides: the use of conformational analysis in the development of a novel series of potent opioid kappa agonists.

J. Shaw, G. Costello, A. M. Slater, 1991, Journal of medicinal chemistry.

New heterocyclic analogues of 4-(2-chloro-5-methoxyanilino)quinazolines as potent and selective c-Src kinase inhibitors.

B. Barlaam, R. Morgentin, P. Plé, 2005, Bioorganic & medicinal chemistry letters.

Approaches to the synthesis of alkaloids

J. Saxton, G. Costello, 1986 .

A total synthesis of (±)-zoapatanol and demethyl-ORF13811

P. Kocieňski, C. Love, G. Costello, 1989 .

A synthetic approach to zoapatanol and related bicyclic analogues

P. Kocieňski, R. Whitby, G. Costello, 1987 .

A Synthetic Approach to Zoapatanol (I) and Related Bicyclic Analogues.

P. Kocieňski, R. Whitby, G. Costello, 1987 .

Preclinical anticancer activity of the potent, oral Src inhibitor AZD0530

N. Carragher, P. Elvin, B. Davies, 2009, Molecular oncology.

N-(5-chloro-1,3-benzodioxol-4-yl)-7-[2-(4-methylpiperazin-1-yl)ethoxy]-5- (tetrahydro-2H-pyran-4-yloxy)quinazolin-4-amine, a novel, highly selective, orally available, dual-specific c-Src/Abl kinase inhibitor.

L. Otterbein, J. Breed, R. A. Norman, 2006, Journal of medicinal chemistry.

Recent developments related to the EGFR as a target for cancer chemotherapy.

G. Speake, G. Costello, B. Holloway, 2005, Current opinion in pharmacology.

A novel series of potent and selective agonists at the opioid κ-receptor

Gerard F. Costello, Brain G. Main, Jeffrey J. Barlow, 1988 .

361 Preclinical activity of AZD0530, a novel, oral, potent and selective inhibitor of the Src family kinases

P. Plé, J. Curwen, V. Jacobs, 2004 .