Severin Lechner

发表

Target deconvolution of HDAC pharmacopoeia reveals MBLAC2 as common off-target

Aubry K. Miller, Raphael R. Steimbach, B. Kuster, 2022, Nature Chemical Biology.

Development of hetero-triaryls as a new chemotype for subtype-selective and potent Sirt5 inhibition.

C. Ochsenfeld, Hongyan Sun, M. Jung, 2022, European journal of medicinal chemistry.

Target deconvolution of HDAC pharmacopoeia reveals MBLAC2 as common off-target

Aubry K. Miller, Raphael R. Steimbach, B. Kuster, 2022, Nature Chemical Biology.

Aza-SAHA Derivatives Are Selective Histone Deacetylase 10 Chemical Probes That Inhibit Polyamine Deacetylation and Phenocopy HDAC10 Knockout.

Aubry K. Miller, Raphael R. Steimbach, Magalie N. E. Géraldy, 2021, Journal of the American Chemical Society.

Decrypting drug actions and protein modifications by dose- and time-resolved proteomics

Thomas A. Hopf, Florian P Bayer, B. Kuster, 2023, Science.

A region-resolved proteomic map of the human brain enabled by high-throughput proteomics

B. Kuster, A. Sakhteman, C. Krisp, 2023, bioRxiv.

Chemoproteomic target deconvolution reveals Histone Deacetylases as targets of (R)-lipoic acid

Aubry K. Miller, Raphael R. Steimbach, B. Kuster, 2023, Nature communications.

High-Throughput Screening and Proteomic Characterization of Compounds Targeting Myeloid-Derived Suppressor Cells

B. Kuster, Hannes Hahne, M. Klingenspor, 2023, Molecular & cellular proteomics : MCP.

Targeting LC3/GABARAP for degrader development and autophagy modulation

E. Proschak, V. Rogov, D. Fearon, 2023, bioRxiv.

Aza-SAHA Derivatives Are Selective Histone Deacetylase 10 Chemical Probes That Inhibit Polyamine Deacetylation and Phenocopy HDAC10 Knockout.

Aubry K. Miller, Raphael R. Steimbach, G. Médard, 2022, Journal of the American Chemical Society.

Decrypting lysine deacetylase inhibitor action and protein modifications by dose-resolved proteomics.

Aubry K. Miller, Raphael R. Steimbach, A. Sakhteman, 2024, Cell reports.