E. Knaus

G. Reischl, H. Machulla, L. Wiebe, 2008, Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine.

An improved synthesis of 1,3-dihydro-1-methyl-5-phenyl-2H-pyrido[3,4-e]-1,4-diazepin-2-one via ortho-directed lithiation of 3-tert-butyl and 3-tert-butoxycarbonylaminopyridine

E. Knaus, C. Fiakpui, 1987 .

Syntheses of 4-[1-(2-deoxy-β-D-ribofuranosyl)]-derivatives of 2-substituted-5-fluoroaniline: "cytosine replacement" analogs of deoxycytidine for evaluation as anticancer and antihuman immunodeficiency virus (anti-HIV) agents

J. Balzarini, E. Clercq, L. Wiebe, 2000 .

Enantioselective syntheses and calcium channel modulating effects of (+)- and (-)-3-isopropyl 5-(4-methylphenethyll) 1,4-dihydro-2,6-dimethyl-4-(2-pyridyl)-3,5-pyridinedicarboxylates.

E. Knaus, M. Wolowyk, N. Iqbal, 1994, Chirality.

Syntheses, calcium channel agonist-antagonist modulation activities, and nitric oxide release studies of nitrooxyalkyl 1,4-dihydro-2,6-dimethyl-3-nitro-4-(2,1,3-benzoxadiazol-4-yl)pyridine-5-carboxylate racemates, enantiomers, and diastereomers.

E. Knaus, Carlos A. Velázquez, R. Shan, 2004, Journal of medicinal chemistry.

Hantzsch 1,4-dihydropyridines containing a diazen-1-ium-1,2-diolate nitric oxide donor moiety to study calcium channel antagonist structure-activity relationships and nitric oxide release.

J. Nguyen, E. Knaus, Carlos A. Velázquez, 2005, Bioorganic & medicinal chemistry.

Chiral synthesis of 4-[1-(2-deoxy-beta-L-ribofuranosyl)] derivatives of 2-substituted 5-fluoroaniline: "cytosine replacement" analogues of deoxy-beta-L-cytidine.

E. De Clercq, J. Balzarini, L. Wiebe, 2000, The Journal of organic chemistry.

Synthesis and calcium channel antagonist activity of dialkyl 1,4-dihydro-2,6-dimethyl-4-(pyridinyl)-3,5-pyridinedicarboxylates.

C. Triggle, L. Dagnino, E. Knaus, 1986, Journal of medicinal chemistry.

Design, synthesis, and biological evaluation of 6-substituted-3-(4-methanesulfonylphenyl)-4-phenylpyran-2-ones: a novel class of diarylheterocyclic selective cyclooxygenase-2 inhibitors.

Mohsen Amini, Huiying Li, M. Amini, 2003, Journal of medicinal chemistry.

SYNTHESIS AND ANTICONVULSANT ACTIVITY OF 3-3-(DIMETHYLAMINO)-METHYL-5-METHYL-4H-1, 2,4-TRIAZOL-4-YL-4-(O-CHLOROBENZOYL)PYRIDINE

V. Arora, E. Knaus, 1999 .

Design and synthesis of novel rofecoxib analogs as potential cyclooxygenase (COX-2) inhibitors: Replacement of the methylsulfonyl pharmacophore by a sulfonylazide bioisostere

M. J. Uddin, E. Knaus, P. Rao, 2003 .

Synthesis and Structure−Activity Relationship Studies of 1,3-Diarylprop-2-yn-1-ones: Dual Inhibitors of Cyclooxygenases and Lipoxygenases

Qiao-Hong Chen, E. Knaus, P. Rao, 2006 .

Synthesis of Novel 1,4‐Dihydropyridyl Substituted Acetic Acids, Esters and Amides and their Evaluation as Analgesic Anti‐inflammatory Agents

E. Knaus, S. A. Agudoawu, 2011 .

Design and syntheses of 4-[3-(1-methoxycarbonyl-1,6-dihydropyridyl)]- and 4-[3-(1-methoxycarbonyl-4-substituted-1,4-dihydropyridyl)]- derivatives of alkyl 1,4-dihydro-2,6-dimethyl-3-nitro-5-pyridine-carboxylates with calcium channel modulating activities

M. Amini, E. Knaus, C. McEwen, 2001 .

Design and syntheses of methyl 2‐methyl‐2‐[2‐(4‐benzoyl‐5‐phenyl‐7‐halo‐2‐azabicyclo[4.1.0]hept‐3‐ene)]acetates: novel inhibitors of cyclooxygenase‐2 (COX‐2) with analgesic‐antiinflammatory activity

Huiying Li, M. Suresh, E. Knaus, 2000 .

Synthesis of celecoxib analogs that possess a N-hydroxypyrid-2(1H)one 5-lipoxygenase pharmacophore: biological evaluation as dual inhibitors of cyclooxygenases and 5-lipoxygenase with anti-inflammatory activity.

M. Suresh, Khaled R. A. Abdellatif, D. Das, 2008, Bioorganic & medicinal chemistry letters.

Synthesis of 1-(methanesulfonyl- and aminosulfonylphenyl)acetylenes that possess a 2-(N-difluoromethyl-1,2-dihydropyridin-2-one) pharmacophore: evaluation as dual inhibitors of cyclooxygenases and 5-lipoxygenase with anti-inflammatory activity.

Moshfiqur Rahman, M. Suresh, Khaled R. A. Abdellatif, 2009, Bioorganic & medicinal chemistry letters.

5-alkynyl analogs of arabinouridine and 2'-deoxyuridine: cytostatic activity against herpes simplex virus and varicella-zoster thymidine kinase gene-transfected cells.

E. De Clercq, J. Balzarini, G. Andrei, 2007, Journal of medicinal chemistry.

Design, synthesis, and structure-activity relationship studies of 3,4,6-triphenylpyran-2-ones as selective cyclooxygenase-2 inhibitors.

M. J. Uddin, E. Knaus, P. Rao, 2004, Journal of medicinal chemistry.

Novel nonsteroidal antiinflammatory drugs possessing a nitric oxide donor diazen-1-ium-1,2-diolate moiety: design, synthesis, biological evaluation, and nitric oxide release studies.

E. Knaus, P. N. Praveen Rao, Carlos A. Velázquez, 2005, Journal of medicinal chemistry.

Synthesis of alkyl 6‐methyl‐4‐(2‐trifluoromethylphenyl)‐1,2,3,4‐tetrahydro‐2H‐pyrimidine‐2‐one‐5‐carboxylates possessing a N‐3 nitro substituent to determine calcium channel modulation structure‐activity relationships

K. Kaur, E. Knaus, 2007 .

Improved Synthesis of Chiral N-Protected Allylic Amines

Zhong Wei, E. Knaus, 1994 .

Synthesis and antiinflammatory activity of 5-(1,6-dihydropyridyl)-tetrazol-2-acetic acids, esters and amides.

E. Knaus, P. Kumar, P. Kumar, 1994, Drug design and discovery.

Synthesis and Calcium Channel Modulating Effects of Isopropyl 1,4‐Dihydro‐2,6‐dimethyl‐3‐nitro‐4‐(thienyl)‐5‐pyridinecarboxylates

S. Howlett, R. Miri, E. Knaus, 1997, Archiv der Pharmazie.

Synthesis of N-[[(substituted-phenyl)carbonyl]amino]-1,2,3,6-tetrahydropyridines with analgesic and hyperglycemic activity.

E. Knaus, J. M. Yeung, L. A. Corleto, 1982, Journal of medicinal chemistry.

Synthesis and antinociceptive activity of 1-methylpiperidylidene-2-(pyridyl)sulfonamides and related dihydropyridyl analogs

E. Knaus, J. Buolamwini, 1993 .

Syntheses, calcium channel agonist-antagonist modulation activities, and voltage-clamp studies of isopropyl 1,4-dihydro-2,6-dimethyl-3-nitro-4-pyridinylpyridine-5-carboxylate racemates and enantiomers.

S. Howlett, W. Matowe, E. Knaus, 1995, Journal of medicinal chemistry.

Isomeric acetoxy analogs of celecoxib and their evaluation as cyclooxygenase inhibitors.

A. Bhardwaj, J. Kaur, Zhangjian Huang, 2011, Bioorganic & medicinal chemistry letters.

Synthesis and biological investigations of nitric oxide releasing nateglinide and meglitinide type II antidiabetic prodrugs: in-vivo antihyperglycemic activities and blood pressure lowering studies.

A. Bhardwaj, J. Kaur, F. Plane, 2012, Journal of medicinal chemistry.

Synthesis of valproate, valerate, and 1‐methyl‐1, 4‐dihydropyridyl‐3‐carbonyloxy ester derivatives of Hantzsch 1,4‐dihydropyridines as potential prodrugs and their evaluation as calcium channel antagonist and anticonvulsant agents

E. Knaus, S. Yiu, Edward E. Knaus, 1999 .

Synthesis and biological evaluation of 1,4-dihydropyridine calcium channel modulators having a diazen-1-ium-1,2-diolate nitric oxide donor moiety for the potential treatment of congestive heart failure.

E. Knaus, Carlos A. Velázquez, 2004, Bioorganic & medicinal chemistry.

Synthesis and Antiviral Activity of 5‐Ethyl‐5‐halo‐6‐alkoxy‐(or Azido)‐5,6‐dihydro‐2′‐deoxyuridine Diastereomers as Potential Prodrugs to 5‐Ethyl‐2′‐deoxyuridine

L. Wiebe, E. Knaus, R. Kumar, 1997, Archiv der Pharmazie.

SYNTHESIS AND BIOLOGICAL EVALUATION OF 5-(1-ALKOXY-2-HALOETHYL)-2'-DEOXYURIDINES AND RELATED URACIL ANALOGUES

Rakesh Kumar, L. Wiebe, E. Knaus, 1991 .

Synthesis of pyrimido[1,4]diazepin‐2‐one analogs and their evaluation as anticonvulsant agents

K. Murthy, E. Knaus, 1999 .

Celecoxib analogs possessing a N-(4-nitrooxybutyl)piperidin-4-yl or N-(4-nitrooxybutyl)-1,2,3,6-tetrahydropyridin-4-yl nitric oxide donor moiety: synthesis, biological evaluation and nitric oxide release studies.

Moshfiqur Rahman, M. Suresh, Khaled R. A. Abdellatif, 2010, Bioorganic & medicinal chemistry letters.

Dinitroglyceryl and diazen-1-ium-1,2-diolated nitric oxide donor ester prodrugs of aspirin, indomethacin and ibuprofen: synthesis, biological evaluation and nitric oxide release studies.

M. Suresh, Khaled R. A. Abdellatif, D. Das, 2009, Bioorganic & medicinal chemistry letters.

Syntheses, calcium channel agonist-antagonist modulation activities, nitric oxide release, and voltage-clamp studies of 2-nitrooxyethyl 1,4-dihydro- 2,6-dimethyl-3-nitro-4-(2-trifluoromethylphenyl)pyridine-5-carboxylate enantiomers.

S. Howlett, E. Knaus, R. Shan, 2002, Journal of medicinal chemistry.

Hantzsch 1,4‐dihydropyridines containing a nitrooxyalkyl ester moiety to study calcium channel antagonist structure–activity relationships and nitric oxide release

J. Nguyen, E. Knaus, C. McEwen, 2000 .

Syntheses, calcium channel modulation effects, and nitric oxide release studies of O2‐alkyl‐1‐(pyrrolidin‐1‐yl) diazen‐1‐ium‐1,2‐diolate 4‐aryl(heteroaryl)‐1,4‐dihydro‐2,6‐dimethyl‐3‐nitropyridine‐5‐carboxylates

E. Knaus, D. Vo, Carlos A. Velázquez, 2003 .

Synthesis and calcium channel antagonist activity of dialkyl hexahydro-1,2′,6′-trimethyl[bipyridine]-3′,5′-dicarboxylates

C. Triggle, L. Dagnino, E. Knaus, 1987 .

A regioselective tandem reduction — Wittig-Horner reaction involving the α-ester moiety of diethyl aspartate or glutamate

E. Knaus, Z.‐Y. Wei, 1994 .

Design and synthesis of celecoxib and rofecoxib analogues as selective cyclooxygenase-2 (COX-2) inhibitors: replacement of sulfonamide and methylsulfonyl pharmacophores by an azido bioisostere.

E. Knaus, P. Rao, P. N. Praveen Rao, 2001, Journal of medicinal chemistry.

Design and synthesis of novel celecoxib analogues as selective cyclooxygenase-2 (COX-2) inhibitors: replacement of the sulfonamide pharmacophore by a sulfonylazide bioisostere.

M. J. Uddin, Md Jashim Uddin, Edward E Knaus, 2003, Bioorganic & medicinal chemistry.

Synthesis and biological evaluation of a novel class of rofecoxib analogues as dual inhibitors of cyclooxygenases (COXs) and lipoxygenases (LOXs).

Qiao-Hong Chen, E. Knaus, P. Rao, 2006, Bioorganic & medicinal chemistry.

Diazen-1-ium-1,2-diolated nitric oxide donor ester prodrugs of 5-(4-carboxymethylphenyl)-1-(4-methanesulfonylphenyl)-3-trifluoromethyl-1H-pyrazole and its aminosulfonyl analog: Synthesis, biological evaluation and nitric oxide release studies.

M. Suresh, Khaled R. A. Abdellatif, D. Das, 2008, Bioorganic & medicinal chemistry.

Design and synthesis of acyclic triaryl (Z)-olefins: a novel class of cyclooxygenase-2 (COX-2) inhibitors.

M. J. Uddin, E. Knaus, P. Rao, 2004, Bioorganic & medicinal chemistry.

Evolution of nonsteroidal anti-inflammatory drugs (NSAIDs): cyclooxygenase (COX) inhibition and beyond.

Edward E Knaus, Praveen Rao, E. Knaus, 2008, Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques.

Synthesis of heterocyclic 1,4-dihydropyridylacetic acid derivatives of 6-aminopenicillanic acid and D-α-aminobenzylpenicillin with antibacterial activity

S. Dubey, E. Knaus, 1985 .

Some reactions of 2-n-butyl(phenyl)-1,2-dihydropyridines with isocyanates, pyridyl esters, and diethyl chlorophosphate

C. Giam, E. Knaus, F. M. Pasutto, 1978 .

Design and syntheses of diarylisoxazoles: Novel inhibitors of cyclooxygenase‐2 (COX‐2) with analgesic‐antiinflammatory activity

E. Knaus, P. Rao, A. G. Habeeb, 2000 .

Syntheses of 1-[(2-Hydroxyethoxy)methyl]- and 1-[(1,3-Dihydroxy-2-Propoxy)methyl]- Derivatives of 5-Substituted-2,4-difluorobenzene: Unnatural Acyclo Thymidine Mimics for Evaluation as Anticancer and Antiviral Agents

J. Balzarini, E. Clercq, L. Wiebe, 2000, Nucleosides, nucleotides & nucleic acids.

Phosphorylation of Isocarbostyril‐ and Difluorophenyl‐Nucleoside Thymidine Mimics by the Human Deoxynucleoside Kinases

S. Eriksson, L. Wiebe, E. Naimi, 2004, Nucleosides, nucleotides & nucleic acids.

Synthesis of chiral 5-substituted 2-pyrrolidinones: An unusual one-step transformation

Z. Y. Wei, E. Knaus, 1993 .

Synthesis of dialkyl 1,4‐dihydro‐2,6‐dimethylpyridine‐3,5‐dicarboxylates and alkyl 1,4‐dihydro‐2,6‐dimethyl‐3‐nitropyridine‐5‐carboxylates possessing a c‐4 2,4‐dioxo‐1,2,3,4‐tetrahydropyrimidin‐5‐yl (uracil) substituent to determine calcium channel modulation structure‐activity relationships

A. Fassihi, E. Knaus, Carlos A. Velázquez, 2004 .

Some reactions of 1,2‐dihydropyridines with cyanogen azide. Synthesis of üiazabieyclo[4.1.0]hept‐4‐enes

E. Knaus, T. A. Ondrus, C. S. Ciam, 1979 .

Some reactions of N-substituted-1,2-dihydropyridines with cyanogen azide. Synthesis of 1,2,3,4-tetrahydropyridylidene-4-cyanamides

C. Giam, E. Knaus, T. A. Ondrus, 1978 .

Some reactions of 1‐lithio‐2‐n‐butyl‐1,2‐dihydropyridine. VI. Synthesis of β‐substituted pyridines

C. Giam, E. Knaus, T. A. Ondrus, 1976 .

Diels‐alder cycloadditions of N‐substituted‐1,2‐dihydropyridines with 1,2,4‐triazoline‐3,5‐diones and maleimides

E. A. Swinyard, C. Giam, E. Knaus, 1976 .

A PRACTICAL PROCEDURE FOR THE SYNTHESIS OF 5-SUBSTITUTED ?-LACTAMS

E. Knaus, Zhenyi Wei, 1993 .

Synthesis and Calcium Channel Antagonist Activity of 3-Arylmethyl 5-Isopropyl l,4-Dihydro-2,6-dimethyl-4-(pyridyl)-3,5-pyridinedicarboxylates

W. Matowe, M. Akula, E. Knaus, 2004, Pharmaceutical Research.

Design and syntheses of C‐4 4‐(1‐methoxycarbonyl‐1,2‐dihydropyridyl)‐, and 3‐[1‐methoxycarbonyl‐1,2‐(and 1,6‐)dihydropyridyl]‐, derivatives of alkyl 1,4‐dihydro‐2,6‐dimethyl‐3‐nitro‐5‐pyridinecarboxylates with cardiospecific calcium channel agonist activity

W. Matowe, E. Knaus, M. Wolowyk, 2000 .

Synthesis of Dialkyl 1,4-Dihydro-2,6-dimethyl-4-(heteroaryl)-pyridine-3,5-dicarboxylates as Calcium Channel Antagonists

E. Knaus, R. Anana, 1997 .

Synthesis and Smooth Muscle Calcium Channel Effects of Dialkyl 1,4‐Dihydro‐2,6‐dimethyl‐4‐aryl‐3,5‐pyridinedicarboxylates Containing a Nitrone Moiety in the 4‐Aryl Substituent

S. Howlett, E. Knaus, R. Anana, 1997, Archiv der Pharmazie.

Synthesis and Calcium Channel Modulating Effects of Alkyl 1,4‐Dihydro‐2,6‐dimethyl‐4‐(pyridinyl or 2‐trifluoromethylphenyl)‐5‐(1H‐tetrazol‐5‐yl)‐3‐pyridinecarboxylates

E. Knaus, N. Iqbal, 1995 .

Specific inhibition of Ca‐activated K channels in red cells by selected dihydropyridine derivatives

P. Smith, J. Ellory, S. Culliford, 1994, British journal of pharmacology.

Synthesis and analgesic activity of 3-methyl derivatives of 4-(pyridyl) isosteres of ketobemidone

E. Knaus, J. Buolamwini, 1992 .

Synthesis and calcium channel modulation effects of isopropyl 1,4‐dihydro‐2,6‐dimethyl‐3‐nitro‐4‐phenylpyridine‐5‐carboxylates possessing ortho‐, meta‐, and para‐CH2S(O)nMe and –S(O)nMe (n = 0–2) phenyl substituents

E. Knaus, N. Iqbal, C. McEwen, 2000 .

Some reactions of 1-methyl-(2-phenylethyl)-1,2,3,4-tetrahydropyridines with organic azides. Synthesis of 1-methyl-(2-phenylethyl)piperidylidene-2-sulfonamides

E. Knaus, B. Warren, 1987 .

Synthesis of 3'- and 5'-nitrooxy pyrimidine nucleoside nitrate esters: "nitric oxide donor" agents for evaluation as anticancer and antiviral agents.

E. De Clercq, J. Balzarini, Aihua Zhou, 2003, Journal of medicinal chemistry.

Design, syntheses, and evaluation of 2,3‐diphenylcycloprop‐2‐en‐1‐ones and oxime derivatives as potential cyclooxygenase‐2 (COX‐2) inhibitors with analgesic‐antiinflammatory activity

Huiying Li, E. Knaus, P. N. Praveen Rao, 2002 .

Synthesis and reactions of 1-hydroxy-1-(pyridinyl)-2-propanones

K. Redda, A. Benderly, E. Knaus, 1980 .

Evaluation of Methylthio‐, Methylsulfinyl‐, and Methylsulfonyl‐Analogs of Alkanes and Alkanoic Acids as Cardiac Inotropic and Antifungal Agents

S. Sardari, M. Daneshtalab, E. Knaus, 2000, Archiv der Pharmazie.

6-Alkyl, alkoxy, or alkylthio-substituted 3-(4-methanesulfonylphenyl)-4-phenylpyran-2-ones: a novel class of diarylheterocyclic selective cyclooxygenase-2 inhibitors.

Mohsen Amini, Huiying Li, M. Amini, 2003, Bioorganic & medicinal chemistry letters.

Radiolabeled L-fucose for diagnostic oncology: preliminary studies in mice and rats using L-1-14C-fucose.

W. Knapp, L. Wiebe, F. Helus, 1985, International journal of nuclear medicine and biology.

The sodium borohydride reduction of N-sulfonylpyridinium salts. Synthesis of N-sulfonyl-1,4-(1,2-) dihydropyridines

K. Redda, E. Knaus, 1977 .

The sodium borohydrirle reduction of N-iminopyridinium ylides. I. Synthesis of N-imino-1,2,3,6-tetrahydropyridines

K. Redda, E. Knaus, 1976 .

Synthesis of 6,7,8,9‐tetrahydro‐5H‐pyrimido‐[4,5‐b][1,4]diazepine‐6,8‐diones

O. Phillips, E. Knaus, 1993 .

Structural modifications at the 2'- and 3'-positions of some pyrimidine nucleosides as determinants of their interaction with the mouse erythrocyte nucleoside transporter.

H. Misra, L. Wiebe, W. P. Gati, 1984, Biochemical pharmacology.

Synthesis, rotamer orientation, and calcium channel modulation activities of alkyl and 2-phenethyl 1,4-dihydro-2,6-dimethyl-3-nitro-4-(3- or 6-substituted-2-pyridyl)-5-pyridinecarboxylates.

W. Matowe, M. Akula, E. Knaus, 1998, Journal of medicinal chemistry.

Design, synthesis, and biological evaluation of linear 1-(4-, 3- or 2-methylsulfonylphenyl)-2-phenylacetylenes: a novel class of cyclooxygenase-2 inhibitors.

Qiao-Hong Chen, E. Knaus, P. Rao, 2005, Bioorganic & medicinal chemistry.

An improved synthesis of 14C-labelled 2,2'-anhydrouridine, 2'-deoxyuridine and 5-ethyl-2'-deoxyuridine

L. Wiebe, J. Mercer, E. Knaus, 1986 .

Synthesis and Antiviral Activity of 1-β-D-Arabinofuranosyluracils and Uridines Containing 5-[2-Bromo-2-chloro (or Bromo)-1-Hydroxy (or Methoxy) Ethyl] Substituents

Rakesh Kumar, L. Wiebe, E. Knaus, 1993 .

Synthesis of brain‐targeted 5‐iodo‐, 5‐vinyl‐ and (E)‐5‐(2‐iodovinyl)‐2′‐deoxyuridines coupled to a dihydropyridine ⇌ pyridinium salt redox chemical delivery system

Rakesh Kumar, L. Wiebe, E. Knaus, 1991 .

Design and synthesis of (E)-1,1,2-triarylethenes: novel inhibitors of the cyclooxygenase-2 (COX-2) isozyme.

M. J. Uddin, R. McDonald, E. Knaus, 2005, Bioorganic & medicinal chemistry letters.

Synthesis and Antifungal Activities of Myristic Acid Analogs

K. Parang, F. Csizmadia, L. Wiebe, 1996, Archiv der Pharmazie.

Synthesis and calcium channel antagonist activity of dialkyl 4- (dihydropyridinyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinecarboxylates.

C. Triggle, L. Dagnino, E. Knaus, 1987, Journal of medicinal chemistry.

Phenylacetic acid regioisomers possessing a N-difluoromethyl-1,2-dihydropyrid-2-one pharmacophore: evaluation as dual inhibitors of cyclooxygenases and 5-lipoxygenase with anti-inflammatory activity.

M. Suresh, Khaled R. A. Abdellatif, D. Das, 2010, Bioorganic & medicinal chemistry letters.

Heterocyclic 1,2-epoxyalkan-3-ones as cytotoxic agents

T. Allen, E. Knaus, D. Vo, 1988 .

Synthesis and reactions of heterocyclic 2,3-epoxypropionitriles with pyrrolidine

E. Knaus, K. C. Agarwal, 1987 .

Synthesis and reactions of 1‐[1‐oxido‐2‐(3,4)‐pyridinyl]‐2‐methyloxiranes with nitrogen nucleophiles

E. Knaus, K. Avasthi, 1981 .

Syntheses of N-substituted 2(3,4)-pyridylcarboxylic acid hydrazides with analgesic and antiinflammatory activity.

K. Redda, E. Knaus, L. A. Corleto, 1979, Journal of medicinal chemistry.

Synthesis and tumor uptake of 5-halo-1-(2'-fluoro-2'-deoxy-beta-D-ribofuranosyl)[2-14C]uracils.

L. Wiebe, J. Mercer, E. Knaus, 1987, Journal of medicinal chemistry.

The Separation, Identification, and Quantitation of Cannabinoids and Their t-Butyldimethylsilyl, Trimethylsilylacetate, and Diethylphosphate Derivatives Using High-Pressure Liquid Chromatography, Gas-Liquid Chromatography, and Mass Spectrometry

R. T. Coutts, E. Knaus, C. Kazakoff, 1976 .

Synthesis and biological evaluation of N-difluoromethyl-1,2-dihydropyrid-2-one acetic acid regioisomers: dual inhibitors of cyclooxygenases and 5-lipoxygenase.

M. Suresh, Khaled R. A. Abdellatif, D. Das, 2010, Bioorganic & medicinal chemistry letters.

Synthesis of Alkyl 6‐Methyl‐4‐ (2‐pyridyl)‐1,2,3,4‐tetrahydro‐2H‐pyrimidine‐2‐one‐5‐carboxylates for Evaluation as Calcium Channel Antagonists.

K. Kaur, E. Knaus, 2007 .

Glycosylated diazeniumdiolate-based oleanolic acid derivatives: synthesis, in vitro and in vivo biological evaluation as anti-human hepatocellular carcinoma agents.

Jide Tian, Yihua Zhang, H. Ji, 2012, Organic & biomolecular chemistry.

Aspirin Analogues as Dual Cyclooxygenase‐2/5‐Lipoxygenase Inhibitors: Synthesis, Nitric Oxide Release, Molecular Modeling, and Biological Evaluation as Anti‐Inflammatory Agents

A. Bhardwaj, J. Kaur, Zhangjian Huang, 2012, ChemMedChem.

Acyclic triaryl olefins possessing a sulfohydroxamic acid pharmacophore: synthesis, nitric oxide/nitroxyl release, cyclooxygenase inhibition, and anti-inflammatory studies.

J. Reisz, Khaled R. A. Abdellatif, S. King, 2010, Organic & biomolecular chemistry.

In vitro antiviral activities of myristic acid analogs against human immunodeficiency and hepatitis B viruses.

K. Parang, D. Tyrrell, F. Csizmadia, 1997, Antiviral research.

Cytotoxicity and cellular uptake of pyrimidine nucleosides for imaging herpes simplex type-1 thymidine kinase (HSV-1 TK) expression in mammalian cells.

A. McEwan, Aihua Zhou, L. Wiebe, 2004, Nuclear medicine and biology.

Synthesis of [2-14C]-labelled 2,2′-anhydrouridine and 2'-deoxyuridine derivatives. A convenient route to [2-14C]-labelled 5-ethynyl- and 5-ethyl-2′-deoxyuridine

L. Wiebe, J. Mercer, R. J. Flanagan, 1985 .

In vitro anti-hepatitis B virus activities of 5"-O-myristoyl analogue derivatives of 3"-fluoro-2",3"-dideoxythymidine (FLT) and 3"-azido-2",3"-dideoxythymidine (AZT).

K. Parang, D. Tyrrell, L. Wiebe, 1998, Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques.

Synthesis and antiviral activity of novel 5-(1-azido-2-haloethyl) and 5-(1-azido-, amino-, or methoxyethyl) analogs of 2'-deoxyuridine.

L. Wiebe, E. Knaus, R. Kumar, 1993, Journal of medicinal chemistry.

Pharmacokinetics and metabolism of E-5-(2-[131I]iodovinyl)-2'-deoxyuridine in dogs

D. Tyrrell, L. Wiebe, J. Samuel, 1986, Antimicrobial Agents and Chemotherapy.

Synthesis, In Vitro Biological Stability, and Anti-HIV Activity of 5-Halo (or Methoxy)-6-Alkoxy (Azido or Hydroxy)-5,6-Dihydro-2′,3′-Didehydro-3′-Deoxythymidine Diastereomers as Potential Prodrugs of 2′,3′-Didehydro-3′-deoxythymidine (D4T)

L. Wiebe, Rohtash Kumar, Li-li Wang, 1996 .

Synthesis of brain-targeted 1-(2-deoxy-2-fluoro-beta-D-ribofuranosyl)-(E)-5-(2-iodovinyl)uracil coupled to a dihydropyridine <---> pyridinium salt redox chemical-delivery system.

L. Wiebe, K. Morin, E. Knaus, 1993, Carbohydrate research.

Bioavailability and pharmacokinetic parameters for 5-ethyl-2'-deoxyuridine.

L. Wiebe, E. Knaus, A. Cheraghali, 1994, Antiviral research.

A Comparative Study of 5-ethyl-2′-Deoxyuridine and Selected Lipophilic 5,6-Dihydro Double/Triple Prodrugs

E. De Clercq, K. Morin, L. Wiebe, 1995 .

Accumulation of 5‐Ethyl‐2′‐deoxyuridine and its 5,6‐Dihydro Prodrugs in Murine Lung and its Potential Clinical Application

Rakesh Kumar, L. Wiebe, K. Morin, 1995, The Journal of pharmacy and pharmacology.

Tumor uptake of radiolabelled pyrimidine bases and pyrimidine nucleosides in animal models--V. 6-[36Cl]chlorouracil, 6-[82Br]bromouracil and 6-[123I]iodouracil.

L. Wiebe, D. Abrams, E. Knaus, 1984, International Journal of Nuclear Medicine and Biology.

Synthesis of [2‐14C]‐1‐(2‐deoxy‐2‐fluoro‐β‐D‐arabinofuranosyl)‐5‐fluoro(chloro)uracil

H. Misra, L. Wiebe, E. Knaus, 1987 .

The synthesis of radiolabelled 1-(2′-Fluoro-2′-deoxy-β-D-ribofuranosyl)-uracil and 1-(2′-chloro-2′-deoxy-β-D-ribofuranosyl)uracil

L. Wiebe, J. Mercer, D. Abrams, 1985 .

Synthesis of 21-[82Br]-21-deoxyuridine

L. Wiebe, E. Knaus, Yip W. Lee, 1980 .

Reaction of 1-(2′,3′-epoxy-β-D-lyxofuranosyl)uracil with hydrogen fluoride. The unexpected formation of 1-(3′-fluoro-3′-deoxy-β-D-ribofuranosyl)uracil

H. Misra, L. Wiebe, W. P. Gati, 1984 .

Synthesis of 5-[1-hydroxy (or methoxy)-2,2-dihaloethyl]-2'- deoxyuridines with antiviral and cytotoxic activity.

T. Allen, E. Knaus, R. Kumar, 1994, Antiviral research.

Synthesis and Anti-Hiv Activity of 3′-0-Formyl Derivatives of Thymidine and 2′-Deoxyuridine

Rakesh Kumar, L. Wiebe, E. Knaus, 1992 .

The synthesis of [36Cl]-, [82Br]- and [123I]-labelled 1-(3'-chloro-(bromo and iodo)-3'-deoxy-beta-D-arabinofuranosyl)uracil.

L. Wiebe, J. Mercer, E. Knaus, 1984, The International journal of applied radiation and isotopes.

Interaction of 2'-halogeno-2'-deoxyuridines with the human erythrocyte nucleoside transport mechanism.

L. Wiebe, W. P. Gati, E. Knaus, 1983, Molecular pharmacology.

Tumor uptake of radiolabeled pyrimidine bases and pyrimidine nucleosides in animal models--III. 2'-[82Br]-bromo-2'-deoxyuridine.

L. Wiebe, E. Knaus, Y. W. Lee, 1979, International journal of nuclear medicine and biology.

Dual-acting 5-Fluorodeoxyuridine (FUdR) Prodrugs: Cell Death Induced by 3'-O-retinoyl-5-fluoro-2'-deoxyuridine and 5'-O-(bis(2,2,2,-trichloroethyl) phosphoryl-3'-O-butanoyl)-5-fluoro-2'-deoxyuridine

L. Wiebe, Zuping Xia, E. Knaus, 2013 .

Aziridination of the uracil 5,6-olefinic bond of 3-N-3′,5′-Di-O-tribenzoyl-5-vinyl-2′-deoxyuridine

T. T. Nakashima, L. Wiebe, Rohtash Kumar, 1991 .

Biochemical and pharmacokinetic evaluation of a novel pyrimidine nucleoside nitric oxide donor as a potential anticancer/antiviral agent.

L. Wiebe, E. Naimi, E. Knaus, 2003, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Synthesis of 1‐(2‐deoxy‐β‐D‐ribofuranosyl)‐2,4‐ difluoro‐5‐(2‐halo‐1‐hydroxyethyl)benzenes and related derivatives: “thymine replacement” analogs of deoxythymidine for evaluation as antiviral and anticancer agents

E. De Clercq, J. Balzarini, L. Wiebe, 2001 .

Synthesis of the diastereomers of 5-(2,2-dichlorocyclopropyl)- and 5-(2-chlorocyclopropyl)-2'-deoxyuridine, and the antiviral and cytotoxic activity of these and bromo analogues.

L. Wiebe, M. Tandon, W. P. Gati, 1991, Drug design and delivery.

Synthesis of 5-[1-hydroxy(or methoxy)-2-bromo(or chloro)ethyl]-2'-deoxyuridines and related halohydrin analogues with antiviral and cytotoxic activity.

D. Tyrrell, T. Allen, L. Wiebe, 1989, Journal of medicinal chemistry.

Design and synthesis of the 3′‐aminocarbonylamino, aminothiocarbonylamino and N‐(Hydroxy)guanidinyl derivatives of thymidine as potential anti‐HIV agents

Rakesh Kumar, L. Wiebe, K. Morin, 1991 .

Production of 34m Cl from a gaseous hydrogen sulfide target

L. Wiebe, W. Maier-borst, D. Abrams, 1984 .

Drug-induced perturbations in the in vivo distribution of oncological radiotracers--I. 5-Fluoro-6-3H-2'-deoxyuridine influenced by nitrobenzylthioinosine 5'-phosphate (NBMPR-P).

L. Wiebe, E. Knaus, 1986, International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology.

Synthesis of 5-(1-azidovinyl) and 5-[2-(1-azirinyl)] analogs of 2′-deoxyuridine

Rakesh Kumar, L. Wiebe, E. Knaus, 1996 .

Synthesis and properties of 5-(1,2-dihaloethyl)-2′-deoxyuridines and related analogues

L. Wiebe, Rohtash Kumar, E. Knaus, 1991 .

Synthesis and tumor uptake of 5-bromine-82- and 5-iodine-131-labeled 5-halo-1-(2-fluoro-2-deoxy-.beta.-D-ribofuranosyl)uracils

L. Wiebe, J. Mercer, E. Knaus, 1989 .

Synthesis and tumor uptake of 5-82Br- and 5-131I-labeled 5-halo-1-(2-fluoro-2-deoxy-beta-D-ribofuranosyl)uracils.

L. Wiebe, J. Mercer, E. Knaus, 1989, Journal of medicinal chemistry.

[125I]iodohydroxynitrobenzylthioinosine: a new high-affinity nucleoside transporter probe.

A. Paterson, L. Wiebe, W. P. Gati, 1987, Biochemistry and cell biology = Biochimie et biologie cellulaire.

Synthesis, in vitro anti-HIV activity, and biological stability of 5'-O-myristoyl analogue derivatives of 3'-fluoro-2',3'-dideoxythymidine (FLT) as potential bifunctional prodrugs of FLT.

K. Parang, L. Wiebe, E. Knaus, 1998, Nucleosides & nucleotides.

BILIARY EXCRETION AND BLOOD/PLASMA RATIO OF NOVEL 5-BROMO-6-ALKOXY-5,6-DIHYDRO PRODRUGS OF 5-ETHYL-2'-DEOXYVRIDINE

Rakesh Kumar, L. Wiebe, K. Morin, 1998 .

Synthesis of 5‐(1‐azido‐2‐haloethyl)arabinouridines

L. Wiebe, Rohtash Kumar, E. Knaus, 1997 .

Synthesis and Antiviral Activity of Novel 5‐(1‐Azido‐2‐haloethyl) and 5‐(1‐Azido‐, Amino‐, or Methoxyethyl) Analogs of 2′‐Deoxyuridine.

L. Wiebe, Rohtash Kumar, E. Knaus, 1994 .

A human osteosarcoma cell line expressing herpes simplex type-1 thymidine kinase: studies with radiolabeled (E)-5-(2-iodovinyl)-2'-fluoro-2'-deoxyuridine.

L. Wiebe, A. Mcewan, K. Morin, 2005, Nuclear medicine and biology.

Synthesis of (E)-5-(2-cIOdovinyl)-3′-0-(1-Methyl-1,4-Dihydropyridyl-3 -Carbonyl)-2′-Fluoro-2′-Deoxyuridine (Ivfru-Cds) for Brain Targetted Delivery of Ivfru, an Antiviral Nucleoside

Rakesh Kumar, L. Wiebe, E. Knaus, 1993 .

Drug-induced perturbations in the in vivo distribution of oncological radiotracers--II. 5-[125I]iodo-2'-deoxyuridine influenced by nitrobenzylthioinosine-5'-phosphate (NBMPR-P) and acyclothymidine (ACT).

L. Wiebe, T. Iwashina, W. P. Gati, 1990, International journal of radiation applications and instrumentation. Part A, Applied radiation and isotopes.

Pharmacokinetics and metabolism of the novel synthetic C‐nucleoside, 1‐(2‐deoxy‐β‐D‐ribofuranosyl)‐2,4‐difluoro‐ 5‐iodobenzene: a potential mimic of 5‐iodo‐2′‐deoxyuridine

L. Wiebe, E. Naimi, E. Knaus, 2002, Biopharmaceutics & drug disposition.

Synthesis and biodistribution of [4-14C]-5-bromo-6-methoxy-5,6-dihydro-prodrug derivatives of 5-ethyl-2'-deoxyuridine.

L. Wiebe, K. Morin, E. Knaus, 1994, Drug design and discovery.

Synthesis of Unnatural 7-Substituted-1-(2-deoxy-β-D-ribofuranosyl)isocarbostyrils: “Thymine Replacement” Analogues of Deoxythymidine for Evaluation as Antiviral and Anticancer Agents.

L. Wiebe, E. Naimi, E. Knaus, 2002 .

SYNTHESIS OF 1-(2-DEOXY-β-D- RIBOFURANOSYL)-2,4-DIFLUORO-5-SUBSTITUTED-BENZENE THYMIDINE MIMICS,* SOME RELATED α-ANOMERS, AND THEIR EVALUATION AS ANTIVIRAL AND ANTICANCER AGENTS

E. De Clercq, J. Balzarini, L. Wiebe, 2001, Nucleosides, nucleotides & nucleic acids.

Radiopharmaceuticals to monitor gene transfer.

L I Wiebe, L. Wiebe, K W Morin, 1997, The quarterly journal of nuclear medicine : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology.

Synthesis of 5-(1-Azidovinyl) and 5-(2-(1-Azirinyl)) Analogues of 2′- Deoxyuridine.

Rakesh Kumar, L. Wiebe, E. Knaus, 1997 .

Synthesis and cyclooxygenase inhibitory activities of linear 1-(methanesulfonylphenyl or benzenesulfonamido)-2-(pyridyl)acetylene regioisomers.

Khaled R. A. Abdellatif, Qiao-Hong Chen, M. Chowdhury, 2008, Bioorganic & medicinal chemistry.

Synthesis, in vitro Biological Stability, and Anti‐HIV Activity of 5‐ Halo (or Methoxy)‐6‐alkoxy (Azido or Hydroxy)‐5,6‐dihydro‐2′,3′‐ didehydro‐3′‐deoxythymidine Diastereomers as Potential Prodrugs of 2′, 3′‐Didehydro‐3′‐deoxythymidine (D4T).

L. Wiebe, Rohtash Kumar, Li-li Wang, 1996 .

Phenylethynylbenzenesulfonamide regioisomers strongly and selectively inhibit the transmembrane, tumor-associated carbonic anhydrase isoforms IX and XII over the cytosolic isoforms I and II.

C. Supuran, A. Scozzafava, A. Innocenti, 2011, Bioorganic & medicinal chemistry letters.

Synthesis of [6-36Cl]chlorouracil, [6-82Br]bromouracil and [6-123I]iodouracil☆

L. Wiebe, D. Abrams, E. Knaus, 1984 .

Some regio- and stereochemical aspects of the Diels-Alder reaction of nitrosocarbonyl compounds with N-substituted 1,2-dihydropyridines

S. Dubey, E. Knaus, 1985 .

Diels–Alder cycloadditions of N-substituted-1,2-dihydropyridines with nitrosobenzene. Synthesis of 3-phenyl-2-oxa-3,6-diazabicyclo[2.2.2]oct-7-enes

C. Giam, E. Knaus, K. Avasthi, 1980 .

The synthesis of -substituted-2-phenyl-1,2-dihydropyridines

C. Giam, E. Knaus, 1971 .

REEXAMINATION OF STEREOCHEMICAL ISSUES CONCERNING 2-PHENYL-1,2-DIHYDROPYRIDINE-MALEIMIDE CYCLOADDITIONS

G. Krow, E. Knaus, D. Zacharias, 1982 .

DIELS-ALDER CYCLOADDITIONS OF 1,2,4-TRIAZOLINE-3,5-DIONES WITH N-SUBSTITUTED-1,2-DIHYDROPYRIDINES

C. Giam, E. Knaus, F. M. Pasutto, 1974 .

Discovery of phosphorodiamidate mustard-based O2-phosphorylated diazeniumdiolates with potent anticancer activity

Huibin Zhang, Yihua Zhang, Zhangjian Huang, 2017 .

O2-acetoxymethyl-protected diazeniumdiolate-based NSAIDs (NONO-NSAIDs): synthesis, nitric oxide release, and biological evaluation studies.

L. Keefer, M. Citro, E. Knaus, 2007, Bioorganic & medicinal chemistry.

Synthesis and biological evaluation of 3,4-diphenyl-1,2,5-oxadiazole-2-oxides and 3,4-diphenyl-1,2,5-oxadiazoles as potential hybrid COX-2 inhibitor/nitric oxide donor agents.

R. McDonald, E. Knaus, P. Rao, 2005, Bioorganic & medicinal chemistry.

Suppression of network activity in dorsal horn by gabapentin permeation of TRPV1 channels: Implications for drug access to cytoplasmic targets

J. E. Biggs, Peter A. Smith, P. Stemkowski, 2015, Neuroscience Letters.

CycloSaligenyl Pronucleotides of 5-Iodo and 5-Trifluoromethyl-1-(2-deoxy-β-D-ribofuranosyl)-2,4-difluorobenzene Mimics of Thymidine: Synthesis and Evaluation of this Pronucleotide Monophosphate Delivery System for Compounds with Potential Anticancer Activity

Aihua Zhou, L. Wiebe, E. Knaus, 2003, Nucleosides, nucleotides & nucleic acids.

Diazen-1-ium-1,2-diolated nitric oxide donor ester prodrugs of 1-(4-methanesulfonylphenyl)-5-aryl-1H-pyrazol-3-carboxylic acids: synthesis, nitric oxide release studies and anti-inflammatory activities.

Khaled R. A. Abdellatif, M. Chowdhury, Ying Dong, 2008, Bioorganic & medicinal chemistry.

Design and synthesis of 3'- and 5'-O-(3-benzenesulfonylfuroxan-4-yl)-2'-deoxyuridines: biological evaluation as hybrid nitric oxide donor-nucleoside anticancer agents.

Aihua Zhou, L. Wiebe, E. Knaus, 2004, Journal of medicinal chemistry.

Synthesis of [5‐14C]‐1,1,12,12‐tetraethoxy‐4,9‐diazadodecane dinitrate

L. Wiebe, T. Hall, V. Somayaji, 1989 .

A Mouse Tumor Model for Screening Radiotracer Uptake into Primary Neoplasms and Metastatic Disease

L. Wiebe, A. Kanclerz, E. Knaus, 1987 .

Sulfonamido, azidosulfonyl and N-acetylsulfonamido analogues of rofecoxib: 4-[4-(N-acetylsulfonamido)phenyl]-3-(4-methanesulfonylphenyl)-2(5H)furanone is a potent and selective cyclooxygenase-2 inhibitor.

A. Zarghi, E. Knaus, P. N. Praveen Rao, 2004, Bioorganic & medicinal chemistry letters.

Design, syntheses, and evaluation of novel 1,1‐dihalo‐2,3‐diphenylcyclopropanes as potential cyclooxygenase‐2 (COX‐2) inhibitors with analgesic‐antiinflammatory activity

E. Knaus, P. Rao, A. G. Habeeb, 2002 .

Diazen-1-ium-1,2-diolated nitric oxide donor ester prodrugs of 5-(4-hydroxymethylphenyl)-1-(4-aminosulfonylphenyl)-3-trifluoromethyl-1H-pyrazole and its methanesulfonyl analog: synthesis, biological evaluation and nitric oxide release studies.

M. Suresh, Khaled R. A. Abdellatif, D. Das, 2008, Bioorganic & medicinal chemistry.

Triaryl (Z)-olefins suitable for radiolabeling with iodine-124 or fluorine-18 radionuclides for positron emission tomography imaging of estrogen positive breast tumors.

Khaled R. A. Abdellatif, Zhangjian Huang, M. Chowdhury, 2011, Bioorganic & medicinal chemistry letters.

Synthesis and biological evaluation of 1,3-diphenylprop-2-en-1-ones possessing a methanesulfonamido or an azido pharmacophore as cyclooxygenase-1/-2 inhibitors.

A. Zarghi, F. Shirazi, Tannaz Zebardast, 2006, Bioorganic & medicinal chemistry.

Do nitric oxide-releasing drugs offer a potentially new paradigm for the management of cardiovascular risks in diabetes?

A. Bhardwaj, J. Kaur, F. Wuest, 2014, Expert review of cardiovascular therapy.

Celecoxib prodrugs possessing a diazen-1-ium-1,2-diolate nitric oxide donor moiety: synthesis, biological evaluation and nitric oxide release studies.

M. Suresh, Khaled R. A. Abdellatif, D. Das, 2010, Bioorganic & medicinal chemistry letters.

Synthesis of new 1‐[4‐methane(amino)sulfonylphenyl)]‐5‐[4‐(aminophenyl)]‐3‐trifluoromethyl‐1H‐pyrazoles

Khaled R. A. Abdellatif, M. Chowdhury, E. Knaus, 2008 .

N-1 and C-3 substituted indole Schiff bases as selective COX-2 inhibitors: synthesis and biological evaluation.

A. Bhardwaj, J. Kaur, Zhangjian Huang, 2012, Bioorganic & medicinal chemistry letters.

Synthesis and biological evaluation of salicylic acid and N-acetyl-2-carboxybenzenesulfonamide regioisomers possessing a N-difluoromethyl-1,2-dihydropyrid-2-one pharmacophore: dual inhibitors of cyclooxygenases and 5-lipoxygenase with anti-inflammatory activity.

M. Suresh, Khaled R. A. Abdellatif, D. Das, 2009, Bioorganic & medicinal chemistry letters.

Nitric oxide, a possible mediator of 1,4‐dihydropyridine‐induced photorelaxation of vascular smooth muscle

C. Triggle, D. Bieger, F. Lovren, 1996, British journal of pharmacology.

The design of (-)-(S)-2-nitrooxyethyl 1,4-dihydro-2,6-dimethyl-3-nitro-4-(2-trifluoromethylphenyl) pyridine-5-carboxylate: a cardioselective positive inotropic derivative of Bay K 8644.

E. Knaus, R. Shan, 1999, Bioorganic & Medicinal Chemistry Letters.

Syntheses, calcium channel agonist‐antagonist modulation effects, and nitric oxide release studies of [3‐(Benzenesulfonyl)furoxan‐4‐yloxy]alkyl 1,4‐Dihydro‐2,6‐dimethyl‐5‐nitro‐4‐(2‐trifluoromethylphenyl, benzofurazan‐4‐yl, 2‐, 3‐, or 4‐pyridyl)‐3‐pyridinecarboxylates

J. Nguyen, E. Knaus, D. Vo, 2002 .

The Design of (-)-(S)-2-Nitrooxyethyl 1,4-Dihydro-2,6-dimethyl-3-nitro-4- (2-trifluoromethylphenyl)pyridine-5-carboxylate: A Cardioselective Positive Inotropic Derivative of Bay K 8644.

E. Knaus, R. Shan, 1999 .

Synthesis and Biological Evaluation of Butanoate, Retinoate, and Bis(2,2,2‐trichloroethyl)phosphate Derivatives of 5‐Fluoro‐2′‐deoxyuridine and 2′,5‐Difluoro‐2′‐deoxyuridine as Potential Dual Action Anticancer Prodrugs

G. Miller, L. Wiebe, Zuping Xia, 1999, Archiv der Pharmazie.

Can nitric oxide-releasing hybrid drugs alleviate adverse cardiovascular risks?

A. Bhardwaj, J. Kaur, E. Knaus, 2013, Future Medicinal Chemistry.

Synthesis and cytotoxic activity of pyridylthio, pyridylsulfinyl, and pyridylsulfonyl methyl acrylates.

L. A. Nelson, T. Allen, O. Phillips, 1989, Drug design and delivery.

Syntheses, Calcium Channel Antagonist and Anticonvulsant Activities of Substituted 1,4‐Dihydro‐3,5‐pyridinedicarboxylates Containing Various 3‐Alkyl Ester Substituents

E. Knaus, S. Yiu, 1997, Archiv der Pharmazie.

A mechanism-based cleavage of lactam-carbamates

Z. Y. Wei, E. Knaus, Z. Wei, 1994 .

A Mechanism‐Based Cleavage of Lactam Carbamates.

Z. Y. Wei, E. Knaus, 1994 .

Tumor uptake of radiolabeled pyrimidine bases and pyrimidine nucleosides in animal models--I. 6-[3H]-5-fluorouracil.

L. Wiebe, D. Abrams, E. Knaus, 1979, International Journal of Nuclear Medicine and Biology.

An efficient, high specific activity radioiodination of 5‐(1‐hydroxy/methoxy‐2‐iodoethyl)‐2′‐deoxyuridine by isotope exchange labelling in pivalic acid melt

Rakesh Kumar, L. Wiebe, T. Iwashina, 1990 .

Tumor uptake of radiolabelled pyrimidine bases and pyrimidine nucleosides in animal models: VII. [2-14C]-5-ethyl-1-(2'-deoxy-beta-D-ribofuranosyl)uracil.

L. Wiebe, J. Giziewicz, E. Knaus, 1984, The International journal of applied radiation and isotopes.

An Improved Synthesis of High-Purity Felodipine.

E. Knaus, S. Yiu, 1996 .

Hybrid fluorescent conjugates of COX-2 inhibitors: search for a COX-2 isozyme imaging cancer biomarker.

A. Bhardwaj, J. Kaur, F. Wuest, 2013, Bioorganic & medicinal chemistry letters.

The in vitro evaluation of nucleoside analogues as probes for use in the noninvasive diagnosis of herpes simplex encephalitis.

D. Tyrrell, H. Misra, L. Wiebe, 1988, Drug design and delivery.

Synthesis and biological evaluation of 1,3-diphenylprop-2-yn-1-ones as dual inhibitors of cyclooxygenases and lipoxygenases.

Qiao-Hong Chen, E. Knaus, P. Rao, 2005, Bioorganic & medicinal chemistry letters.

A diazen-1-ium-1,2-diolated nitric oxide donor ester prodrug of 3-(4-hydroxymethylphenyl)-4-(4-methanesulfonylphenyl)-5H-furan-2-one: synthesis, biological evaluation and nitric oxide release studies.

Khaled R. A. Abdellatif, S. Kaufman, Zhangjian Huang, 2011, Bioorganic & medicinal chemistry letters.

Synthesis of new 4-[2-(4-methyl(amino)sulfonylphenyl)-5-trifluoromethyl-2H-pyrazol-3-yl]-1,2,3,6-tetrahydropyridines: a search for novel nitric oxide donor anti-inflammatory agents.

Khaled R. A. Abdellatif, M. Chowdhury, Ying Dong, 2008, Bioorganic & medicinal chemistry.

Design of acyclic triaryl olefins: a new class of potent and selective cyclooxygenase-2 (COX-2) inhibitors.

M. J. Uddin, E. Knaus, P. Rao, 2004, Bioorganic & medicinal chemistry letters.

Nucleosides de dihydropyrimidine a proprietes antivirales

Rakesh Kumar, L. Wiebe, E. Knaus, 1993 .

Synthesis and biological evaluation of linear phenylethynylbenzenesulfonamide regioisomers as cyclooxygenase-1/-2 (COX-1/-2) inhibitors.

Qiao-Hong Chen, E. Knaus, P. Rao, 2006, Bioorganic & medicinal chemistry.

Structure of (+)‐(5R,6R)‐5‐Chloro‐6‐methoxy‐5,6‐dihydro‐1‐(2′,3′‐ didehydro‐2′,3′‐dideoxy‐β‐D‐glycero‐2‐enopentofuranosyl)thymine

M. James, H. Blanchard, L. Wiebe, 1993 .

Some reactions of 10-substituted-10H-pyrido[3,2-b][1,4]benzothiazine-n-butyllithium adducts with acyl and sulfonyl chlorides

E. Knaus, F. M. Pasutto, 1979 .

Structure of (+)-(5R,6R)-5-chloro-6-methoxy-5,6-dihydro-1-(2',3'-didehydro-2',3'-dideoxy-β-d-glycero-2-enopentofuranosyl)thymine

M. James, H. Blanchard, Rakesh Kumar, 1993 .

The cytostatic activity of 5‐(1‐azidovinyl)‐2′‐deoxyuridine (AzVDU) against herpes simplex virus thymidine kinase gene‐transfected FM3A cells is due to inhibition of thymidylate synthase and enhanced by UV light (λ = 254 nm) exposure

E. De Clercq, J. Balzarini, G. Andrei, 1995, FEBS letters.

Synthesis and biological evaluation of indomethacin analogs possessing a N-difluoromethyl-1,2-dihydropyrid-2-one ring system: a search for novel cyclooxygenase and lipoxygenase inhibitors.

Khaled R. A. Abdellatif, Zhangjian Huang, M. Chowdhury, 2010, Bioorganic & medicinal chemistry letters.

Rofecoxib Analogues Possessing a Nitric Oxide Donor Sulfohydroxamic Acid (SO2NHOH) Cyclooxygenase‐2 Pharmacophore: Synthesis, Molecular Modeling, and Biological Evaluation as Anti‐inflammatory Agents

A. Bhardwaj, J. Kaur, Zhangjian Huang, 2012, ChemMedChem.

Fluorophore‐Labeled Cyclooxygenase‐2 Inhibitors for the Imaging of Cyclooxygenase‐2 Overexpression in Cancer: Synthesis and Biological Studies

A. Bhardwaj, J. Kaur, F. Wuest, 2014, ChemMedChem.

Synthesis and calcium channel modulating effects of modified Hantzsch nitrooxyalkyl 1,4‐dihydro‐2,6‐dimethyl‐3‐nitro‐4‐(pyridinyl or 2‐trifluoromethylphenyl)‐5‐pyridinecarboxylates

R. Miri, E. Knaus, C. McEwen, 2000 .

Non‐invasive scintigraphic monitoring of gene expression in a HSV‐1 thymidine kinase gene therapy model

L. Wiebe, K. Morin, E. Knaus, 1997, Nuclear medicine communications.

Synthesis of N-(carbonylamino)-1,2,3,6-tetrahydropyridines with analgesic, antiinflammatory, and hyperglycemic activity.

E. Knaus, J. M. Yeung, L. A. Corleto, 1982, Journal of medicinal chemistry.

Concepts for the design of anti-HIV nucleoside prodrugs for treating cephalic HIV infection.

L. Wiebe, Wiebe, Knaus, 1999, Advanced drug delivery reviews.

Synthesis and reactions of heterocyclic methyl 2-propenoates and 2,3-epoxypropanoates with nucleophiles

E. Knaus, K. C. Agarwal, 1985 .

SYNTHESIS OF UNNATURAL 7-SUBSTITUTED-1-(2-DEOXY-β-D-RIBOFURANOSYL)ISOCARBOSTYRILS†: “THYMINE REPLACEMENT” ANALOGS OF DEOXYTHYMIDINE FOR EVALUATION AS ANTIVIRAL AND ANTICANCER AGENTS

L. Wiebe, E. Naimi, E. Knaus, 2001, Nucleosides, nucleotides & nucleic acids.

Synthesis and Analgesic Activity of 2‐Methyl‐2‐[1‐(3‐benzoyl‐4‐substituted‐1,4‐dihydropyridyl)]acetic Acid Methyl Esters, Acetic Acids, and Acetamides

J. Wallace, E. Knaus, S. Yiu, 1999, Archiv der Pharmazie.

Moshfiqur Rahman, M. Suresh, Khaled R. A. Abdellatif, 2010, Bioorganic & medicinal chemistry letters.

The influence of tumor stage and metastasis on the biodistribution of gallium-67 citrate in the murine Lewis lung carcinoma model.

L. Wiebe, A. Kanclerz, E. Knaus, 1988, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

Cardiovascular Properties of a Nitric Oxide Releasing Rofecoxib Analogue: Beneficial Anti‐hypertensive Activity and Enhanced Recovery in an Ischemic Reperfusion Injury Model

A. Bhardwaj, J. Kaur, J. Seubert, 2012, ChemMedChem.

N-1 and C-3 substituted indole Schiff bases as selective COX-2 inhibitors: synthesis and biological evaluation.

A. Bhardwaj, J. Kaur, Zhangjian Huang, 2012, Bioorganic & medicinal chemistry letters.

Triaryl (Z)-olefins suitable for radiolabeling with carbon-11 or fluorine-18 radionuclides for positron emission tomography imaging of cyclooxygenase-2 expression in pathological disease.

Khaled R. A. Abdellatif, Zhangjian Huang, M. Chowdhury, 2010, Bioorganic & medicinal chemistry letters.

Synthesis and evaluation of {125I}‐(E)‐5‐(2‐iodovinyl)‐N3‐methyl‐2′‐deoxy‐uridine as a potential probe for the non‐invasive diagnosis of herpes simplex encephalitis

D. Tyrrell, L. Wiebe, M. Tandon, 1989 .

Pharmacokinetics and bioavailability of 5-ethyl-2'-deoxyuridine and its novel (5R,6R)-5-bromo-6-ethoxy-5,6-dihydro prodrugs in mice.

L. Wiebe, E. Knaus, A. Cheraghali, 1995, Drug metabolism and disposition: the biological fate of chemicals.

Enzyme-targeted, nucleoside-based radiopharmaceuticals for scintigraphic monitoring of gene transfer and expression.

L. Wiebe, E. Knaus, 2001, Current pharmaceutical design.

Radiosynthesis, in vitro cellular uptake and in vivo biodistribution of 3'-O-(3-benzenesulfonylfuroxan-4-yl)-5-[125I]iodo-2'-deoxyuridine, a nucleoside-based nitric oxide donor.

Piyush Kumar, Aihua Zhou, L. Wiebe, 2005, Nuclear medicine and biology.

Aspirin Analogues as Dual Cyclooxygenase‐2/5‐Lipoxygenase Inhibitors: Synthesis, Nitric Oxide Release, Molecular Modeling, and Biological Evaluation as Anti‐Inflammatory Agents

A. Bhardwaj, J. Kaur, Zhangjian Huang, 2012, ChemMedChem.

Design and synthesis of (Z)-1,2-diphenyl-1-(4-methanesulfonamidophenyl)alk-1-enes and (Z)-1-(4-azidophenyl)-1,2-diphenylalk-1-enes: novel inhibitors of cyclooxygenase-2 (COX-2) with anti-inflammatory and analgesic activity.

E. Knaus, P. Rao, M. Uddin, 2005, Bioorganic & medicinal chemistry.