R. Arafa

发表

Design, synthesis and structure-activity relationship of novel semi-synthetic flavonoids as antiproliferative agents.

F. Ragab, M. El-Naa, T. A. A. Yahya, 2014, European journal of medicinal chemistry.

Synthesis and antiprotozoal activity of dicationic m-terphenyl and 1,3-dipyridylbenzene derivatives.

D. Boykin, Xiaohua Zhu, R. Brun, 2013, Journal of medicinal chemistry.

Molecular modeling, spectral, and biological studies of 4-formylpyridine-4N-(2-pyridyl) thiosemicarbazone (HFPTS) and its Mn(II), Fe(III), Co(II), Ni(II), Cu(II), Cd(II), Hg(II), and UO2(II) complexes

R. Arafa, U. el-Ayaan, Nashwa M. El Metwally, 2014, Journal of Thermal Analysis and Calorimetry.

Induced topological changes in DNA complexes: influence of DNA sequences and small molecule structures

W. Wilson, Arvind Kumar, D. Boykin, 2011, Nucleic acids research.

Docking study, in vitro anticancer screening and radiosensitizing evaluation of some new fluorine-containing quinoline and pyrimidoquinoline derivatives bearing a sulfonamide moiety

F. Ragab, M. Ghorab, H. Heiba, 2011, Medicinal Chemistry Research.

In vitro anticancer screening and radiosensitizing evaluation of some new quinolines and pyrimido[4,5-b]quinolines bearing a sulfonamide moiety.

F. Ragab, M. Ghorab, H. Heiba, 2010, European journal of medicinal chemistry.

Design of DNA minor groove binding diamidines that recognize GC base pair sequences: a dimeric-hinge interaction motif.

P. Peixoto, C. Bailly, W. Wilson, 2007, Journal of the American Chemical Society.

Synthesis, DNA affinity, and antiprotozoal activity of fused ring dicationic compounds and their prodrugs.

W. Wilson, D. Boykin, R. Brun, 2005, Journal of medicinal chemistry.

Synthesis, antimicrobial activity and molecular modeling study of substituted 5-aryl-pyrimido[5,4-c]quinoline-2,4-diones

S. Al-Shihry, M. Ismail, R. Arafa, 2013, Journal of enzyme inhibition and medicinal chemistry.

Molecular modeling study and synthesis of novel dicationic flexible triaryl guanidines and imidamides as antiprotozoal agents.

W. Wilson, R. Brun, Yun Chai, 2011, European journal of medicinal chemistry.

Anticancer activity, dual prooxidant/antioxidant effect and apoptosis induction profile of new bichalcophene-5-carboxamidines.

M. Ismail, A. Negm, E. Abdel‐Latif, 2019, European journal of medicinal chemistry.

New thiobarbituric acid scaffold‐based small molecules: Synthesis, cytotoxicity, 2D‐QSAR, pharmacophore modelling and in‐silico ADME screening

M. Elaasser, Heba S A El-Zahabi, A. Farrag, 2019, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Novel anti-HIV-1 NNRTIs based on a pyrazolo[4,3-d]isoxazole backbone scaffold: design, synthesis and insights into the molecular basis of action

M. G. Badrey, M. Abdalla, R. Arafa, 2014 .

Novel sulfonamides bearing pyrrole and pyrrolopyrimidine moieties as carbonic anhydrase inhibitors: Synthesis, cytotoxic activity and molecular modeling.

C. Supuran, Y. M. Nissan, M. Ceruso, 2014, European journal of medicinal chemistry.

Design, synthesis and molecular docking of novel N,N-dimethylbenzenesulfonamide derivatives as potential antiproliferative agents

M. Alsaid, M. Ghorab, R. Arafa, 2014, Journal of enzyme inhibition and medicinal chemistry.

Molecular determinants for DNA minor groove recognition: design of a bis-guanidinium derivative of ethidium that is highly selective for AT-rich DNA sequences.

Christian Bailly, C. Bailly, P. Colson, 2005, Biochemistry.

Novel pyrrole derivatives as selective CHK1 inhibitors: design, regioselective synthesis and molecular modeling

Mohamed M. Abdulla, Taha M. A. Eldebss, R. Arafa, 2015 .

Design, Synthesis and Potential Anti-Proliferative Activity of Some Novel 4-Aminoquinoline Derivatives

M. Al-Said, M. Ghorab, R. Arafa, 2014, Acta pharmaceutica.

Novel heterocyclic-fused pyrimidine derivatives: synthesis, molecular modeling and pharmacological screening.

R. Arafa, Nehad A. El-Sayed, Mai S Nour, 2013, European journal of medicinal chemistry.

Synthesis and antiprotozoal activity of novel bis-benzamidino imidazo[1,2-a]pyridines and 5,6,7,8-tetrahydro-imidazo[1,2-a]pyridines.

W. Wilson, D. Boykin, R. Brun, 2008, Bioorganic & medicinal chemistry.

Novel Benzo[d]imidazole-based Heterocycles as Broad Spectrum Anti-viral Agents: Design, Synthesis and Exploration of Molecular Basis of Action.

Mohamed M. Abdulla, A. Farag, Taha M. A. Eldebss, 2015, Mini reviews in medicinal chemistry.

Synthesis and activity of azaterphenyl diamidines against Trypanosoma brucei rhodesiense and Plasmodium falciparum.

W. Wilson, D. Boykin, Laixing Hu, 2009, Bioorganic & medicinal chemistry.

Novel linear triaryl guanidines, N-substituted guanidines and potential prodrugs as antiprotozoal agents.

W. Wilson, D. Boykin, R. Brun, 2008, European journal of medicinal chemistry.

Azaterphenyl diamidines as antileishmanial agents.

W. Wilson, D. Boykin, Laixing Hu, 2008, Bioorganic & medicinal chemistry letters.

Synthesis, DNA affinity, and antiprotozoal activity of linear dications: Terphenyl diamidines and analogues.

W. Wilson, D. Boykin, J. Hall, 2006, Journal of medicinal chemistry.

Synthesis and in vitro antiproliferative effect of novel quinoline-based potential anticancer agents.

A. Abadi, G. Piazza, R. Arafa, 2013, European journal of medicinal chemistry.

Design and molecular modeling of novel P38α MAPK inhibitors targeting breast cancer, synthesized from oxygen heterocyclic natural compounds.

Hamed I. Ali, Z. A. Abd Elmageed, R. Arafa, 2019, Bioorganic & medicinal chemistry.

In vitro activity and preliminary toxicity of various diamidine compounds against Trypanosoma evansi.

Arvind Kumar, D. Boykin, R. Brun, 2010, Veterinary parasitology.

UCH-L3 structure and function: Insights about a promising drug target.

R. Arafa, N. Hafez, Zahraa Modather, 2021, European journal of medicinal chemistry.

Discovery of novel quinazolinones and their acyclic analogues as multi-kinase inhibitors: design, synthesis, SAR analysis and biological evaluation

A. A. Eissa, R. Arafa, Mohamed M. Abdullah, 2016 .

Discovery of PIM-1 kinase inhibitors based on the 2,5-disubstituted 1,3,4-oxadiazole scaffold against prostate cancer: Design, synthesis, in vitro and in vivo cytotoxicity investigation.

Mohamed S. Nafie, Anne‐Sophie Castanet, R. Arafa, 2023, European journal of medicinal chemistry.

Design and Synthesis of Novel Benzopyran‐2‐one Derivatives of Expected Antimicrobial Activity through DNA Gyrase‐B Inhibition

N. Farag, G. S. Hassan, R. Arafa, 2008, Archiv der Pharmazie.

Design and Synthesis of Novel Benzopyran‐2‐one Derivatives of Expected Antimicrobial Activity Through DNA Gyrase‐B Inhibition.

N. Farag, G. S. Hassan, R. Arafa, 2009 .

Induced fit conformational changes of a "reversed amidine" heterocycle: optimized interactions in a DNA minor groove complex.

Stephen Neidle, Christian Bailly, Yang Liu, 2007, Journal of the American Chemical Society.

3,5-Diarylisoxazoles: Individualized Three-Step Synthesis and Isomer Determination Using 13C NMR or Mass Spectroscopy

C. E. Stephens, R. Arafa, 2006 .

Trypanocidal activity and selectivity in vitro of aromatic amidine compounds upon bloodstream and intracellular forms of Trypanosoma cruzi.

D. Boykin, M. Ismail, M. N. Soeiro, 2011, Experimental parasitology.

SLE, An Overlooked Disease: Possibilities for Early Rescue by Early Diagnosis

Mariam Ahmed, R. Arafa, Reem K. Arafa, 2018, Rapid Test - Advances in Design, Format and Diagnostic Applications.

Design and synthesis of new 2-oxoquinoxalinyl-1,2,4-triazoles as antitumor VEGFR-2 inhibitors.

R. Arafa, A. Balkan, Oya Unsal Tan, 2022, Bioorganic chemistry.

Synthesis of functionalized flavones from 3-halo-2-(methylthio)-4H-chromen-4-ones

R. Pratap, R. Arafa, Amr Elagamy, 2022, Tetrahedron Letters.

New oxadiazoles with selective-COX-2 and EGFR dual inhibitory activity: Design, synthesis, cytotoxicity evaluation and in silico studies.

Reem K. Arafa, M. Salem, R. Arafa, 2019, European journal of medicinal chemistry.

Design of DNA minor groove binding diamidines that recognize GC base pair sequences: a dimeric-hinge interaction motif.

P. Peixoto, C. Bailly, D. Boykin, 2007, Journal of the American Chemical Society.

Molecular modeling study and synthesis of novel dicationic flexible triaryl guanidines and imidamides as antiprotozoal agents.

W. Wilson, Yun Chai, R. Arafa, 2011, European journal of medicinal chemistry.