W. McCoull

发表

The acute glucose lowering effect of specific GPR120 activation in mice is mainly driven by glucagon-like peptide 1

A. Nyström, M. Någård, M. S. Winzell, 2017, PloS one.

Development of a novel BCL6 PROTAC to provide insight into small molecule targeting of BCL6

David M. Wilson, Qing Cao, M. Waring, 2018 .

Development of a Novel B-Cell Lymphoma 6 (BCL6) PROTAC To Provide Insight into Small Molecule Targeting of BCL6.

David M. Wilson, Qing Cao, M. Waring, 2018, ACS chemical biology.

Discovery of Pyrazolo[1,5-a]pyrimidine B-Cell Lymphoma 6 (BCL6) Binders and Optimization to High Affinity Macrocyclic Inhibitors.

Matthew Grist, C. Chuaqui, Qing Cao, 2017, Journal of medicinal chemistry.

Concise Asymmetric Synthesis of alpha-Amino Acid Derivatives from N-Sulfinylimino Esters.

F. A. Davis, W. McCoull, 1999, The Journal of organic chemistry.

Asymmetric synthesis of aziridine 2-phosphonates and azirinyl phosphonates from enantiopure sulfinimines

F. A. Davis, W. McCoull, 1999 .

A-loop interactions in Mer tyrosine kinase give rise to inhibitors with two-step mechanism and long residence time of binding

J. Nissink, R. Overman, P. Rawlins, 2020, The Biochemical journal.

Identification and Strategies to Mitigate High Total Clearance of Benzylamine-Substituted Biphenyl Ring Systems.

B. Williamson, Aixiang Xue, S. Boyd, 2022, Molecular pharmaceutics.

Design and optimisation of dendrimer-conjugated Bcl-2/xL inhibitor, AZD0466, with improved therapeutic index for cancer therapy

E. Hennessy, S. Fawell, B. Davies, 2021, Communications biology.

Indazole-6-phenylcyclopropylcarboxylic Acids as Selective GPR120 Agonists with in Vivo Efficacy.

A. Bailey, Robert D. M. Davies, Alastair J. H. Brown, 2017, Journal of medicinal chemistry.

Optimization of Highly Kinase Selective Bis-anilino Pyrimidine PAK1 Inhibitors.

E. Hennessy, C. Chuaqui, A. Ferguson, 2016, ACS medicinal chemistry letters.

Design, synthesis, and proposed active site binding analysis of monocyclic 2-azetidinone inhibitors of prostate specific antigen.

G. Becker, B. Neubauer, R. Hermann, 2001, Journal of medicinal chemistry.

Pharmacological inhibition of MERTK induces in vivo retinal degeneration: a multimodal imaging ocular safety assessment

M. Coen, A. Doherty, G. Maglennon, 2022, Archives of toxicology.

Prostate-specific antigen (PSA)-mediated proliferation, androgenic regulation and inhibitory effects of LY312340 in HOS-TE85 (TE85) human osteosarcoma cells.

E. Dixon, G. Becker, B. Neubauer, 2002, Anticancer research.

2H-Azirine 3-phosphonates: a new class of chiral iminodienophiles. Asymmetric synthesis of quaternary piperidine phosphonates.

K. Prasad, F. A. Davis, Hongxing Yan, 2002, Organic letters.

Design and synthesis of novel monocyclic β-lactam inhibitors of prostate specific antigen

G. Becker, B. Neubauer, R. Hermann, 1997 .

Asymmetric synthesis of aziridine 2-phosphonates from enantiopure sulfinimines (N-sulfinyl imines). Synthesis of alpha-amino phosphonates.

K. Prasad, F. A. Davis, Hongxing Yan, 2003, The Journal of organic chemistry.

Recent Synthetic Applications of Chiral Aziridines

F. A. Davis, W. McCoull, 2000 .

Identification, optimisation and in vivo evaluation of oxadiazole DGAT-1 inhibitors for the treatment of obesity and diabetes.

Andrew G. Leach, A. Plowright, Robert D. M. Davies, 2012, Bioorganic & medicinal chemistry letters.

Identification and optimisation of 3,3-dimethyl-azetidin-2-ones as potent and selective inhibitors of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1)

S. Steinbacher, M. Augustin, D. Ogg, 2014 .

A study of the intramolecular stille cross coupling reaction of vinylstannyl chloroformates: application to the synthesis of α-methylene lactones

J. Baldwin, R. Adlington, A. Russell, 1994 .

Synthesis of 3-(hetero)aryl tetrahydropyrazolo[3,4-c]pyridines by Suzuki-Miyaura cross-coupling methodology.

G. Lamont, Matthew R. Box, P. Kemmitt, 2014, The Journal of organic chemistry.

Design and Synthesis of Novel Monocyclic β-Lactam Inhibitors of Prostate Specific Antigen.

G. Becker, B. Neubauer, R. Hermann, 1997 .

Asymmetric synthesis of alpha-methylphosphophenylalanine derivatives using sulfinimine-derived enantiopure aziridine-2-phosphonates.

F. A. Davis, W. McCoull, D. D. Titus, 1999, Organic letters.

Asymmetric Synthesis of Aziridine 2-Phosphonates from Enantiopure Sulfinimines (N-Sulfinyl Imines). Synthesis of α-Amino Phosphonates.

K. Prasad, F. A. Davis, Hongxing Yan, 2003 .

Generating Selective Leads for Mer Kinase Inhibitors-Example of a Comprehensive Lead-Generation Strategy.

Anthony D. Keefe, E. Hennessy, A. Keefe, 2021, Journal of medicinal chemistry.

AZD4320, A Dual Inhibitor of Bcl-2 and Bcl-xL, Induces Tumor Regression in Hematologic Cancer Models without Dose-limiting Thrombocytopenia

Tristan J. Lubinski, E. Hennessy, M. Garnett, 2020, Clinical Cancer Research.

8-Substituted analogues of 3-(3-cyclopentyloxy-4-methoxy-benzyl)-8-isopropyl-adenine: highly potent and selective PDE4 inhibitors.

P. Gharagozloo, A. Gehrig, M. Hachicha, 2005, Journal of medicinal chemistry.

Experimental testing of quantum mechanical predictions of mutagenicity: aminopyrazoles.

A. Bailey, A. Leach, C. Mee, 2013, Chemical research in toxicology.

Free Ligand 1D NMR Conformational Signatures to Enhance Structure Based Drug Design of a Mcl-1 inhibitor (AZD5991) and other Synthetic Macrocycles.

Nichola L. Davies, E. Chiarparin, M. Lamb, 2019, Journal of medicinal chemistry.

Identification of pyrazolo-pyrimidinones as GHS-R1a antagonists and inverse agonists for the treatment of obesity

Nathaniel G. Martin, Robert D. M. Davies, P. Macfaul, 2013 .

Identification and optimisation of 7-azaindole PAK1 inhibitors with improved potency and kinase selectivity

E. Hennessy, C. Chuaqui, A. Ferguson, 2014 .

Identification, optimization, and pharmacology of acylurea GHS-R1a inverse agonists.

Nathaniel G. Martin, Robert D. M. Davies, Alastair J. H. Brown, 2014, Journal of medicinal chemistry.

Discovery of a potent, selective, and orally bioavailable acidic 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor: discovery of 2-[(3S)-1-[5-(cyclohexylcarbamoyl)-6-propylsulfanylpyridin-2-yl]-3-piperidyl]acetic acid (AZD4017).

Martin J Packer, Nidhal Selmi, David Hargreaves, 2012, Journal of medicinal chemistry.

Novel thienopyrimidine and thiazolopyrimidine kinase inhibitors with activity against Tie-2 in vitro and in vivo.

Peter Ballard, Leonie Campbell, David Buttar, 2009, Bioorganic & medicinal chemistry letters.

Diels-alder reaction on solid supports using polymer-bound oxazolidinones

J. Winkler, W. McCoull, 1998 .

Optimization of an Imidazo[1,2-a]pyridine Series to Afford Highly Selective Type I1/2 Dual Mer/Axl Kinase Inhibitors with In Vivo Efficacy.

E. Hennessy, Nichola L. Davies, A. Doherty, 2021, Journal of medicinal chemistry.

Design and optimisation of dendrimer-conjugated Bcl-2/xL inhibitor, AZD0466, with improved therapeutic index for cancer therapy

E. Hennessy, S. Fawell, B. Davies, 2021, Communications Biology.