Hwei-Ming Peng

发表

Minor activities and transition state properties of the human steroid hydroxylases cytochromes P450c17 and P450c21, from reactions observed with deuterium-labeled substrates.

S. Matthew, R. Auchus, F. Yoshimoto, 2012, Biochemistry.

Heme-dependent activation of neuronal nitric oxide synthase by cytosol is due to an Hsp70-dependent, thioredoxin-mediated thiol-disulfide interchange in the heme/substrate binding cleft.

J. Gestwicki, W. Pratt, Yoshinari Miyata, 2011, Biochemistry.

Ubiquitylation of Neuronal Nitric-oxide Synthase by CHIP, a Chaperone-dependent E3 Ligase*

C. Patterson, W. Pratt, Y. Morishima, 2004, Journal of Biological Chemistry.

Cytochrome b5 Activates the 17,20-Lyase Activity of Human Cytochrome P450 17A1 by Increasing the Coupling of NADPH Consumption to Androgen Production.

L. Waskell, R. Auchus, A. Turcu, 2016, Biochemistry.

The action of cytochrome b 5 on both CYP2E1 and CYP2C19 activities requires the anionic residues D58 and D65

R. Auchus, Hwei-Ming Peng, 2013 .

Two surfaces of cytochrome b5 with major and minor contributions to CYP3A4-catalyzed steroid and nifedipine oxygenation chemistries.

R. Auchus, Hwei-Ming Peng, 2014, Archives of biochemistry and biophysics.

Epoxidation Activities of Human Cytochromes P450c17 and P450c21

R. Auchus, F. Yoshimoto, Haoming Zhang, 2014, Biochemistry.

Catalytically Relevant Electrostatic Interactions of Cytochrome P450c17 (CYP17A1) and Cytochrome b5*

R. Auchus, H. Tran, S. Anderson, 2014, The Journal of Biological Chemistry.

A-ring modified steroidal azoles retaining similar potent and slowly reversible CYP17A1 inhibition as abiraterone

S. Upadhyay, R. Auchus, F. Yoshimoto, 2014, The Journal of Steroid Biochemistry and Molecular Biology.

Cytochrome P450, a very hard mountain to climb: evidence for multiple functional species of activated oxygen

M. J. Coon, K. P. Vatsis, Hwei-Ming Peng, 2002 .

Predicted Benign and Synonymous Variants in CYP11A1 Cause Primary Adrenal Insufficiency Through Missplicing

P. Hindmarsh, R. Lindsay, C. Brain, 2018, Journal of the Endocrine Society.

of the Endocrine Society Predicted Benign and Synonymous variants in CYP 11 A 1 Causes Primary Adrenal Insufficiency through

P. Hindmarsh, R. Lindsay, E. Duncan, 2018 .

Making water-soluble integral membrane proteins in vivo using an amphipathic protein fusion strategy

L. Pollack, M. DeLisa, Yujie Chen, 2015, Nature Communications.

cDNA and Derived Amino Acid Sequence of Rabbit Nasal Cytochrome P 450 NMb ( P 450 llGl ) , a Unique lsozyme Possibly Involved in Olfaction ’

M. J. Coon, Xinxin Ding, T. Porter, 2003 .

Inhibition of Hsp70 by Methylene Blue Affects Signaling Protein Function and Ubiquitination and Modulates Polyglutamine Protein Degradation*

Jason E Gestwicki, J. Gestwicki, W. Pratt, 2010, The Journal of Biological Chemistry.

Proposal for a role of the Hsp90/Hsp70-based chaperone machinery in making triage decisions when proteins undergo oxidative and toxic damage

W. Pratt, Y. Morishima, Hwei-Ming Peng, 2010, Experimental biology and medicine.

Pharmacologic and genetic inhibition of hsp90-dependent trafficking reduces aggregation and promotes degradation of the expanded glutamine androgen receptor without stress protein induction.

W. Pratt, A. Lieberman, Monzy Thomas, 2006, Human molecular genetics.

Adrenocorticotropin Acutely Regulates Pregnenolone Sulfate Production by the Human Adrenal In Vivo and In Vitro

R. Auchus, A. Turcu, A. Nanba, 2018, The Journal of clinical endocrinology and metabolism.

Molecular Recognition in Mitochondrial Cytochromes P450 That Catalyze the Terminal Steps of Corticosteroid Biosynthesis.

R. Auchus, Hwei-Ming Peng, 2017, Biochemistry.

The action of cytochrome b(5) on CYP2E1 and CYP2C19 activities requires anionic residues D58 and D65.

R. Auchus, Hwei-Ming Peng, 2013, Biochemistry.

Modulation of Heme/Substrate Binding Cleft of Neuronal Nitric-oxide Synthase (nNOS) Regulates Binding of Hsp90 and Hsp70 Proteins and nNOS Ubiquitination*

W. Pratt, Y. Morishima, Hwei-Ming Peng, 2011, The Journal of Biological Chemistry.

C331A Mutant of Neuronal Nitric-oxide Synthase Is Labilized for Hsp70/CHIP (C Terminus of HSC70-interacting Protein)-dependent Ubiquitination*

W. Pratt, Y. Morishima, Hwei-Ming Peng, 2010, The Journal of Biological Chemistry.

Dynamic cycling with Hsp90 stabilizes neuronal nitric oxide synthase through calmodulin-dependent inhibition of ubiquitination.

W. Pratt, Y. Morishima, Hwei-Ming Peng, 2009, Biochemistry.

Regulation of cytochrome P450 2E1 by heat shock protein 90-dependent stabilization and CHIP-dependent proteasomal degradation.

R. Sunahara, W. Pratt, P. Hollenberg, 2005, Biochemistry.

Activation of Hsp70 reduces neurotoxicity by promoting polyglutamine protein degradation

Catherine A. Collins, T. Komiyama, J. Gestwicki, 2012, Nature chemical biology.

Selectivity of osilodrostat as an inhibitor of human steroidogenic cytochromes P450

R. Auchus, Jerry Z Oommen, Hwei-Ming Peng, 2023, The Journal of Steroid Biochemistry and Molecular Biology.

Expression in Escherichia Coli, Purification, and Functional Reconstitution of Human Steroid 5α-Reductases.

R. Auchus, S. Im, Hwei-Ming Peng, 2020, Endocrinology.

Catalytic modulation of human cytochromes P450 17A1 and P450 11B2 by phospholipid

R. Auchus, Hwei-Ming Peng, Chase Barlow, 2018, The Journal of Steroid Biochemistry and Molecular Biology.

Abolition of oxygenase function, retention of NADPH oxidase activity, and emergence of peroxidase activity upon replacement of the axial cysteine-436 ligand by histidine in cytochrome P450 2B4.

M. J. Coon, K. P. Vatsis, Hwei-Ming Peng, 2005, Archives of biochemistry and biophysics.

Replacement of active-site cysteine-436 by serine converts cytochrome P450 2B4 into an NADPH oxidase with negligible monooxygenase activity.

M. J. Coon, Kostas P Vatsis, Hwei-Ming Peng, 2002, Journal of inorganic biochemistry.

Human cytochrome P450 17A1 structures with metabolites of prostate cancer drug abiraterone reveal substrate-binding plasticity and a second binding site

R. Auchus, E. Scott, A. Bart, 2023, The Journal of biological chemistry.

Ubiquitination of Neuronal Nitric-oxide Synthase in the Calmodulin-binding Site Triggers Proteasomal Degradation of the Protein*

M. Ford, Y. Morishima, Gary J. Jenkins, 2012, The Journal of Biological Chemistry.