Jiayun Pang

发表

Evidence to support the hypothesis that promoting vibrations enhance the rate of an enzyme catalyzed H-tunneling reaction.

M. Sutcliffe, N. Scrutton, C. Pudney, 2009, Journal of the American Chemical Society.

Delivering Antisense Oligonucleotides across the Blood‐Brain Barrier by Tumor Cell‐Derived Small Apoptotic Bodies

Junfeng Zhang, Lei Dong, Chunming Wang, 2021, Advanced science.

Large-scale domain conformational change is coupled to the activation of the Co-C bond in the B12-dependent enzyme ornithine 4,5-aminomutase: a computational study.

K. Morokuma, M. Sutcliffe, N. Scrutton, 2012, Journal of the American Chemical Society.

Deep tunneling dominates the biologically important hydride transfer reaction from NADH to FMN in morphinone reductase.

M. Sutcliffe, N. Scrutton, S. Hay, 2008, Journal of the American Chemical Society.

Manipulations of phenylnorbornyl palladium species for multicomponent construction of a bridged polycyclic privileged scaffold

Qingzhong Hu, Lina Yin, Yu-ting He, 2022, Communications Chemistry.

Mutagenesis of morphinone reductase induces multiple reactive configurations and identifies potential ambiguity in kinetic analysis of enzyme tunneling mechanisms.

M. Sutcliffe, N. Scrutton, C. Pudney, 2007, Journal of the American Chemical Society.

Drug-polymer intermolecular interactions in hot-melt extruded solid dispersions.

M. Maniruzzaman, D. Morgan, D. Douroumis, 2013, International journal of pharmaceutics.

Molecular modeling as a predictive tool for the development of solid dispersions.

M. Maniruzzaman, D. Morgan, D. Douroumis, 2015, Molecular pharmaceutics.

Protein motions during catalysis by dihydrofolate reductases

G. Maglia, R. Allemann, Richard S. Swanwick, 2006, Philosophical Transactions of the Royal Society B: Biological Sciences.

Quantum mechanics/molecular mechanics studies on the mechanism of action of cofactor pyridoxal 5'-phosphate in ornithine 4,5-aminomutase.

M. Sutcliffe, N. Scrutton, Jiayun Pang, 2014, Chemistry.

Parallel Pathways and Free‐Energy Landscapes for Enzymatic Hydride Transfer Probed by Hydrostatic Pressure

M. Sutcliffe, N. Scrutton, C. Pudney, 2009, Chembiochem : a European journal of chemical biology.

Barrier compression enhances an enzymatic hydrogen-transfer reaction.

M. Sutcliffe, N. Scrutton, C. Pudney, 2009, Angewandte Chemie.

Integrating computational methods with experiment uncovers the role of dynamics in enzyme catalysed H-tunnelling reactions

M. Sutcliffe, N. Scrutton, L. Johannissen, 2010 .

Secondary kinetic isotope effects as probes of environmentally-coupled enzymatic hydrogen tunneling reactions.

M. Sutcliffe, N. Scrutton, S. Hay, 2008, ChemPhysChem.

Temperature‐dependent study reveals that dynamics of hydrophobic residues plays an important functional role in the mitochondrial Tim9–Tim10 complex

J. Warwicker, M. Sutcliffe, T. Jowitt, 2012, Proteins.

New insights into the molecular mechanism of methanol-induced inactivation of Thermomyces lanuginosus lipase: a molecular dynamics simulation study

P. Busk, L. Lange, Xiaoxue Tong, 2016 .

Reaction of Vascular Adhesion Protein-1 (VAP-1) with Primary Amines

N. Scrutton, S. Rigby, Jiayun Pang, 2011, The Journal of Biological Chemistry.

New insights into the multi-step reaction pathway of the reductive half-reaction catalysed by aromatic amine dehydrogenase: a QM/MM study.

M. Sutcliffe, N. Scrutton, S. D. de Visser, 2010, Chemical communications.

Hydride transfer reaction catalyzed by hyperthermophilic dihydrofolate reductase is dominated by quantum mechanical tunneling and is promoted by both inter- and intramonomeric correlated motions.

Donald G Truhlar, Jiali Gao, Jingzhi Pu, 2006, Journal of the American Chemical Society.

Atomistic insight into the origin of the temperature-dependence of kinetic isotope effects and H-tunnelling in enzyme systems is revealed through combined experimental studies and biomolecular simulation.

M. Sutcliffe, N. Scrutton, L. Johannissen, 2008, Biochemical Society transactions.

Role of tryptophan residues of Erv1: Trp95 and Trp183 are important for its folding and oxidase function

S. Ang, Efraín Ceh-Pavia, Hui Lu, 2015, Bioscience reports.

Molecular dynamics simulation of thermal unfolding of Thermatoga maritima DHFR.

R. Allemann, Jiayun Pang, 2007, Physical chemistry chemical physics : PCCP.

A half-site multimeric enzyme achieves its cooperativity without conformational changes

N. Harmer, Jiayun Pang, M. Vivoli, 2017, Scientific Reports.