S. Narula

发表

SAR of Carbon‐Linked, 2‐Substituted Purines: Synthesis and Characterization of AP23451 as a novel Bone‐Targeted Inhibitor of Src Tyrosine Kinase With In Vivo Anti‐Resorptive Activity

R. Bohacek, L. Xing, B. Boyce, 2008, Chemical biology & drug design.

Investigating protein-ligand interactions with a mutant FKBP possessing a designed specificity pocket.

L. Rozamus, D. Holt, T. Clackson, 2000, Journal of medicinal chemistry.

Mutation of invariant cysteines of mammalian metallothionein alters metal binding capacity, cadmium resistance, and 113Cd NMR spectrum.

P. C. Huang, M. Cismowski, I. Armitage, 1991, The Journal of biological chemistry.

Copper- and silver-substituted yeast metallothioneins: sequential 1H NMR assignments reflecting conformational heterogeneity at the C terminus.

D. Winge, I. Armitage, S. Narula, 1993, Biochemistry.

An efficient synthesis of a 4'-phosphonodifluoromethyl-3'-formyl-phenylalanine containing SRC SH2 ligand.

D. Holt, R. Bohacek, M. Botfield, 1999, Bioorganic & medicinal chemistry letters.

Structural Basis of Src Tyrosine Kinase Inhibition with a New Class of Potent and Selective Trisubstituted Purine‐based Compounds

Susan Adams, William Shakespeare, Thilo Stehle, 2006, Chemical biology & drug design.

Bone-targeted Src kinase inhibitors: novel pyrrolo- and pyrazolopyrimidine analogues.

R. Bohacek, T. Sawyer, W. Shakespeare, 2003, Bioorganic & medicinal chemistry letters.

Structure-based design and synthesis of a novel class of Src SH2 inhibitors.

D. Holt, M. Hatada, R. Bohacek, 1999, Bioorganic & medicinal chemistry letters.

Selective epimerization of rapamycin via a retroaldol/aldol mechanism mediated by titanium tetraisopropoxide.

L. Rozamus, D. Holt, M. Hatada, 1999, Organic letters.

Selective inhibition of Src SH2 by a novel thiol-targeting tricarbonyl-modified inhibitor and mechanistic analysis by (1)H/(13)C NMR spectroscopy.

M. Botfield, M. Weigele, R. Sundaramoorthi, 2001, Bioorganic & medicinal chemistry letters.

3D solution structure of copper and silver‐substituted yeast metallothioneins

C. W. Peterson, I. Armitage, S. Narula, 1996, FEBS letters.

Structure of the binuclear metal-binding site in the GAL4 transcription factor.

K. Gardner, T. Pan, J. Coleman, 1991, Biochemistry.

Three-dimensional solution structure of Callinectes sapidus metallothionein-1 determined by homonuclear and heteronuclear magnetic resonance spectroscopy.

M. Brouwer, I. Armitage, S. Narula, 1995, Biochemistry.

Establishment of two distinct protein domains in blue crab Callinectes sapidus metallothionein‐I through heteronuclear (1H113Cd) and homonuclear 1H1H) correlation NMR experiments

J. Enghild, M. Brouwer, I. Armitage, 1993 .

Novel protein kinase inhibitors: SMART drug design technology.

R. Bohacek, T. Sawyer, W. Shakespeare, 2003, BioTechniques.

SMART Drug Design: Novel Phosphopeptide and ATP Mimetic-Based Small Molecule Inhibitors of the Oncogenic Protein Kinase pp60 src (Src)

R. Bohacek, T. Sawyer, W. Shakespeare, 2005 .

Solution structure of the C-terminal SH2 domain of the human tyrosine kinase Syk complexed with a phosphotyrosine pentapeptide.

M. Hatada, E. Laird, M. Botfield, 1995, Structure.

Structure-based design of an osteoclast-selective, nonpeptide src homology 2 inhibitor with in vivo antiresorptive activity.

M. Hatada, S. Violette, R. Bohacek, 2000, Proceedings of the National Academy of Sciences of the United States of America.

Identification of transient intermediates in the bisphosphatase reaction of rat liver 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase by 31P-NMR spectroscopy.

S. Pilkis, D. Okar, I. Armitage, 1995, The Biochemical journal.

Amide proton hydrogen exchange rates for sperm whale myoglobin obtained from 15N‐1H NMR spectra

H. Dyson, P. Wright, Y. Thériault, 2008, Protein science : a publication of the Protein Society.

Establishment of the Metal-to-Cysteine Connectivities in Silver-Substituted Yeast Metallothionein

R. Mehra, D. Winge, I. Armitage, 1991 .

Bone-targeted 2,6,9-trisubstituted purines: novel inhibitors of Src tyrosine kinase for the treatment of bone diseases.

R. Bohacek, T. Sawyer, W. Shakespeare, 2003, Bioorganic & medicinal chemistry letters.

NMR studies of the heme pocket conformations of monomeric hemoglobins from Glycera dibranchiata. Implications for ligand binding.

P. Wright, R. Cooke, C. Dalvit, 1987, European journal of biochemistry.

X-Ray structure of citrate bound to Src SH2 leads to a high-affinity, bone-targeted Src SH2 inhibitor.

M. Hatada, S. Violette, R. Bohacek, 2001, Journal of medicinal chemistry.

NMR studies of the conformations of leghemoglobins from soybean and lupin.

P. Wright, C. Dalvit, C. Appleby, 1988, European journal of biochemistry.

Structure-based design of novel nonpeptide inhibitors of the Src SH2 domain:phosphotyrosine mimetics exploiting multifunctional group replacement chemistry.

C. Eyermann, R. Bohacek, T. Sawyer, 2003, Biopolymers.

Bone-targeted pyrido[2,3-d]pyrimidin-7-ones: potent inhibitors of Src tyrosine kinase as novel antiresorptive agents.

S. Violette, R. Bohacek, T. Sawyer, 2003, Bioorganic & medicinal chemistry letters.