S. Adams

发表

SAR of Carbon‐Linked, 2‐Substituted Purines: Synthesis and Characterization of AP23451 as a novel Bone‐Targeted Inhibitor of Src Tyrosine Kinase With In Vivo Anti‐Resorptive Activity

R. Bohacek, L. Xing, B. Boyce, 2008, Chemical biology & drug design.

Structural Basis of Src Tyrosine Kinase Inhibition with a New Class of Potent and Selective Trisubstituted Purine‐based Compounds

Susan Adams, William Shakespeare, Thilo Stehle, 2006, Chemical biology & drug design.

Bone-targeted Src kinase inhibitors: novel pyrrolo- and pyrazolopyrimidine analogues.

R. Bohacek, T. Sawyer, W. Shakespeare, 2003, Bioorganic & medicinal chemistry letters.

Selective inhibition of Src SH2 by a novel thiol-targeting tricarbonyl-modified inhibitor and mechanistic analysis by (1)H/(13)C NMR spectroscopy.

M. Botfield, M. Weigele, R. Sundaramoorthi, 2001, Bioorganic & medicinal chemistry letters.

Synergistic stimulation of alkaline phosphatase activity in bovine aortic endothelial cells grown in the presence of retinoids and glucocorticoids

G. Melnykovych, S. Adams, S. Adams, 1985, Journal of cellular physiology.

Bone-targeted Src SH2 inhibitors block Src cellular activity and osteoclast-mediated resorption.

R. Baron, R. Rickles, S. Violette, 2001, Bone.

Simultaneous assay of Src SH3 and SH2 domain binding using different wavelength fluorescence polarization probes.

R. Rickles, K. Loiacono, B. Lynch, 1999, Analytical biochemistry.

Solution structure of the C-terminal SH2 domain of the human tyrosine kinase Syk complexed with a phosphotyrosine pentapeptide.

M. Hatada, E. Laird, M. Botfield, 1995, Structure.

A fluorescence polarization based Src-SH2 binding assay.

K. Loiacono, B. Lynch, I. Macneil, 1997, Analytical biochemistry.

A ligand-reversible dimerization system for controlling protein-protein interactions.

D N Woolfson, D. Holt, M. Hatada, 2000, Proceedings of the National Academy of Sciences of the United States of America.

Structure-based design of an osteoclast-selective, nonpeptide src homology 2 inhibitor with in vivo antiresorptive activity.

M. Hatada, S. Violette, R. Bohacek, 2000, Proceedings of the National Academy of Sciences of the United States of America.

Bone-targeted 2,6,9-trisubstituted purines: novel inhibitors of Src tyrosine kinase for the treatment of bone diseases.

R. Bohacek, T. Sawyer, W. Shakespeare, 2003, Bioorganic & medicinal chemistry letters.

A ligand-reversible dimerization system for controlling protein-protein interactions.

M. Hatada, T. Clackson, D. Woolfson, 2000, Proceedings of the National Academy of Sciences of the United States of America.

Bone-targeted pyrido[2,3-d]pyrimidin-7-ones: potent inhibitors of Src tyrosine kinase as novel antiresorptive agents.

S. Violette, R. Bohacek, T. Sawyer, 2003, Bioorganic & medicinal chemistry letters.