H. Nagabukuro

发表

Metabolomic-/Lipidomic-based Analysis of Plasma to Diagnose Hepatocellular Ballooning in Patients with Nonalcoholic Fatty Liver Disease: A Multicenter Study.

T. Yamanaka, K. Chayama, Hirokazu Takahashi, 2020, Hepatology research : the official journal of the Japan Society of Hepatology.

Differential effects of TAK-802, a selective acetylcholinesterase inhibitor, and carbamate acetylcholinesterase inhibitors on contraction of the detrusor smooth muscle of the guinea pig.

T. Doi, H. Nagabukuro, 2005, Life sciences.

Novel acetylcholinesterase inhibitor as increasing agent on rhythmic bladder contractions: SAR of 8-{3-[1-(3-fluorobenzyl)piperidin-4-yl]propanoyl}-1,2,5,6-tetrahydro-4H-pyrrolo[3,2,1-ij]quinolin-4-one (TAK-802) and related compounds.

M. Sasaki, T. Doi, T. Tsukamoto, 2005, Bioorganic & medicinal chemistry.

Non‐alcoholic steatohepatitis‐associated hepatic fibrosis and hepatocellular carcinoma in a combined mouse model of genetic modification and dietary challenge

Shuntarou Tsuchiya, R. Tozawa, Hironobu Yasuno, 2017, Hepatology research : the official journal of the Japan Society of Hepatology.

Pharmacological evaluation of pioglitazone and candesartan cilexetil in a novel mouse model of non‐alcoholic steatohepatitis, modified choline‐deficient, amino acid‐defined diet fed low‐density lipoprotein receptor knockout mice

M. Asada, Shuntarou Tsuchiya, R. Tozawa, 2017, Hepatology research : the official journal of the Japan Society of Hepatology.

Investigation of piperazine benzamides as human β3 adrenergic receptor agonists for the treatment of overactive bladder.

M. Struthers, R. Berger, C. Moyes, 2017, Bioorganic & medicinal chemistry letters.

Design, synthesis, and evaluation of conformationally restricted acetanilides as potent and selective β3 adrenergic receptor agonists for the treatment of overactive bladder.

M. Struthers, R. Berger, C. Moyes, 2014, Journal of medicinal chemistry.

Combination effects of alogliptin and pioglitazone on steatosis and hepatic fibrosis formation in a mouse model of non-alcoholic steatohepatitis.

K. Tohyama, Shuntarou Tsuchiya, K. Enya, 2018, Biochemical and biophysical research communications.

The LHRH pulse generator: A mediobasal hypothalamic location

S. Ohkura, H. Tsukamura, K. Maeda, 1995, Neuroscience & Biobehavioral Reviews.

Discovery of Vibegron: A Potent and Selective β3 Adrenergic Receptor Agonist for the Treatment of Overactive Bladder.

M. Struthers, R. Berger, C. Moyes, 2016, Journal of medicinal chemistry.

Effects of TAK-802, a novel acetylcholinesterase inhibitor, on distension-induced rhythmic bladder contractions in rats and guinea pigs.

T. Doi, Y. Ishichi, Y. Ishihara, 2004, European journal of pharmacology.

Lipopolysaccharide-induced suppression of the hypothalamic gonadotropin-releasing hormone pulse generator in ovariectomized goats.

Y. Mori, Y. Takeuchi, Y. Takeuchi, 1997, The Journal of veterinary medical science.

Influence of endometriosis on visceromotor and cardiovascular responses induced by vaginal distention in the rat

K. Berkley, H. Nagabukuro, 2007, PAIN.

Transurethral bladder catheterization of male rhesus macaques: a refinement of approach

H. Nagabukuro, L. Gichuru, Cesaire L. Gai, 2011, Journal of medical primatology.

Effects of TAK-802, a novel acetylcholinesterase inhibitor, and various cholinomimetics on the urodynamic characteristics in anesthetized guinea pigs.

T. Doi, S. Okanishi, H. Nagabukuro, 2004, European journal of pharmacology.

Drug reprofiling and repurposing: a state-of-the-art public-private collaboration model

N. Uemura, H. Nagabukuro, 2020, Translational and Regulatory Sciences.

Uncovering a Predictive Molecular Signature for the Onset of NASH-Related Fibrosis in a Translational NASH Mouse Model

R. Goldschmeding, A. van Koppen, S. Turner, 2017, Cellular and molecular gastroenterology and hepatology.

Use of selective PGE2 receptor antagonists on human endometriotic stromal cells and peritoneal macrophages

Y. Osuga, K. Koga, M. Asada, 2020, Molecular human reproduction.

Endocannabinoid involvement in endometriosis

K. Berkley, K. Mackie, Guohua Zhang, 2010, PAIN®.

Urinary liver‐type fatty acid binding protein is increased in the early stages of the disease with a risk of acute kidney injury induced by histone

T. Sugaya, D. Nakae, K. Miyajima, 2023, Nephrology.

Pharmacological Characterization of a Novel Beta 3 Adrenergic Agonist, Vibegron: Evaluation of Antimuscarinic Receptor Selectivity for Combination Therapy for Overactive Bladder

M. Struthers, J. Demartino, J. Woods, 2017, The Journal of Pharmacology and Experimental Therapeutics.

Correlation between pharmacologically-induced changes in cystometric parameters and spinal c-Fos expression in rats

A. Degenhardt, N. Jochnowitz, C. Abbadie, 2010, Autonomic Neuroscience.

Discovery of 5-Chloro-1-(5-chloro-2-(methylsulfonyl)benzyl)-2-imino-1,2-dihydropyridine-3-carboxamide (TAK-259) as a Novel, Selective, and Orally Active α1D Adrenoceptor Antagonist with Antiurinary Frequency Effects: Reducing Human Ether-a-go-go-Related Gene (hERG) Liabilities.

Y. Imai, Masato Yoshida, Nobuki Sakauchi, 2016, Journal of medicinal chemistry.

Comparative Analysis of the Effects of Antimuscarinic Agents on Bladder Functions in Both Nonhuman Primates and Rodents

G. O'neill, S. Alves, X. Tong, 2011, Journal of Pharmacology and Experimental Therapeutics.

Effects of TAK‐802, a novel acetylcholinesterase inhibitor, and tamsulosin, an α1‐adrenoceptor antagonist, and their synergistic effects on the urodynamic characteristics in a guinea‐pig model of functional bladder outlet obstruction

T. Doi, M. Iwata, Tadatoshi Hashimoto, 2005, BJU international.

Increased α1D adrenergic receptor activity and protein expression in the urinary bladder of aged rats

Guohua Zhang, N. Dmitrieva, H. Nagabukuro, 2008, World Journal of Urology.

Effects of the selective acetylcholinesterase inhibitor TAK-802 on the voiding behavior and bladder mass increase in rats with partial bladder outlet obstruction.

T. Doi, Tadatoshi Hashimoto, H. Nagabukuro, 2005, The Journal of urology.

A randomized, placebo-controlled study to evaluate safety and pharmacokinetics of ART-001 with a novel oral pediatric formulation in healthy subjects.

Toshinori Higashi, N. Uemura, H. Nagabukuro, 2023, Clinical and translational science.

Endocannabinoid involvement in endometriosis

K. Berkley, K. Mackie, Guohua Zhang, 2010, PAIN®.