M. D. Powers

发表

Putative Kappa Opioid Heteromers As Targets for Developing Analgesics Free of Adverse Effects

Mark J. Thomas, Mark J Thomas, P. Portoghese, 2014, Journal of medicinal chemistry.

Discovery of Polypharmacological Melanocortin-3 and -4 Receptor Probes and Identification of a 100-Fold Selective nM MC3R Agonist versus a μM MC4R Partial Agonist.

Radleigh G. Santos, M. Giulianotti, R. Houghten, 2019, Journal of medicinal chemistry.

Advances in Brief b-Catenin Mutations Are More Frequent in Small Colorectal Adenomas Than in Larger Adenomas and Invasive Carcinomas 1

M. Slattery, W. Samowitz, L. Spirio, 1999 .

Induced association of mu opioid (MOP) and type 2 cholecystokinin (CCK2) receptors by novel bivalent ligands.

L. Miller, P. Portoghese, M. M. Lunzer, 2009, Journal of medicinal chemistry.

The δ opioid receptor agonist SNC80 selectively activates heteromeric μ-δ opioid receptors.

P. Portoghese, G. Wilcox, K. Kitto, 2012, ACS chemical neuroscience.

Inhibition of Inflammatory and Neuropathic Pain by Targeting a Mu Opioid Receptor/Chemokine Receptor5 Heteromer (MOR-CCR5).

Y. Sham, P. Portoghese, M. M. Lunzer, 2015, Journal of medicinal chemistry.

Beta-catenin mutations are more frequent in small colorectal adenomas than in larger adenomas and invasive carcinomas.

F. van Roy, M. Slattery, W. Samowitz, 1999, Cancer research.

Bivalent ligands that target μ opioid (MOP) and cannabinoid1 (CB1) receptors are potent analgesics devoid of tolerance.

P. Portoghese, M. M. Lunzer, Ajay S. Yekkirala, 2013, Journal of medicinal chemistry.

N-naphthoyl-β-naltrexamine (NNTA), a highly selective and potent activator of μ/κ-opioid heteromers

P. Portoghese, C. McCurdy, S. Roerig, 2011, Proceedings of the National Academy of Sciences.

A κ Opioid Pharmacophore Becomes a Spinally Selective κ-δ Agonist When Modified with a Basic Extender Arm.

P. Portoghese, M. M. Lunzer, Jie Yang, 2011, ACS medicinal chemistry letters.

Opioid activity of spinally selective analogues of N-naphthoyl-β-naltrexamine in HEK-293 cells and mice.

P. Portoghese, M. M. Lunzer, M. Le Naour, 2012, Journal of medicinal chemistry.