Nobuo Machinaga

发表

A Controlled Release System for Long-Acting Intravitreal Delivery of Small Molecules

R. Reid, D. Santi, G. Ashley, 2018, Translational vision science & technology.

Scintillation Proximity Assay to Detect the Changes in Cellular Dihydrosphingosine 1-Phosphate Levels

Ryuji Hashimoto, Fumihito Muro, Nobuo Machinaga, 2016, Lipids.

A novel, potent, and orally active VLA-4 antagonist with good aqueous solubility: trans-4-[1-[[2-(5-Fluoro-2-methylphenylamino)-7-fluoro-6-benzoxazolyl]acetyl]-(5S)-[methoxy(methyl)amino]methyl-(2S)-pyrrolidinylmethoxy]cyclohexanecarboxylic acid.

J. Chiba, M. Yokoyama, S. Iimura, 2013, Bioorganic & medicinal chemistry.

Identification of trans-4-[1-[[7-fluoro-2-(1-methyl-3-indolyl)-6-benzoxazolyl]acetyl]-(4S)-fluoro-(2S)-pyrrolidinylmethoxy]cyclohexanecarboxylic acid as a potent, orally active VLA-4 antagonist.

J. Chiba, M. Yokoyama, S. Iimura, 2012, Bioorganic & medicinal chemistry.

A novel and potent VLA-4 antagonist based on trans-4-substituted cyclohexanecarboxylic acid.

J. Chiba, M. Yokoyama, S. Iimura, 2009, Bioorganic & medicinal chemistry.

Identification of 4-[1-[3-chloro-4-[N'-(5-fluoro-2-methylphenyl)ureido]phenylacetyl]-(4S)-fluoro-(2S)-pyrrolidinylmethoxy]benzoic acid as a potent, orally active VLA-4 antagonist.

J. Chiba, M. Yokoyama, S. Iimura, 2008, Bioorganic & medicinal chemistry.

Synthesis and biological evaluation of benzoic acid derivatives as potent, orally active VLA-4 antagonists.

J. Chiba, M. Yokoyama, A. Satoh, 2007, Bioorganic & medicinal chemistry.

4-(Pyrrolidinyl)methoxybenzoic acid derivatives as a potent, orally active VLA-4 antagonist.

T. Horiuchi, J. Chiba, M. Yokoyama, 2006, Chemical & pharmaceutical bulletin.

Synthesis, biological evaluation, and pharmacokinetic study of prolyl-1-piperazinylacetic acid and prolyl-4-piperidinylacetic acid derivatives as VLA-4 antagonists.

J. Chiba, M. Yokoyama, J. Baldwin, 2006, Bioorganic & medicinal chemistry.

Discovery of trans-4-[1-[[2,5-Dichloro-4-(1-methyl-3-indolylcarboxamido)phenyl]acetyl]-(4S)-methoxy-(2S)-pyrrolidinylmethoxy]cyclohexanecarboxylic acid: an orally active, selective very late antigen-4 antagonist.

J. Chiba, M. Yokoyama, A. Satoh, 2009, Journal of medicinal chemistry.

Total synthesis of (–)-indolizidine 239CD

C. Kibayashi, Nobuo Machinaga, 1991 .

Enantioselective total synthesis of (+)- and (-)-pyrrolidine 197B, a new class of alkaloid from the dendrobatid poison frog: assignment of the absolute configuration

C. Kibayashi, Nobuo Machinaga, 1991 .

General entry to the 3,5-disubstituted indolizidine class of dendrobatid alkaloids. Total syntheses of both enantiomers of indolizidines 195B, 223AB, 239AB, and 239CD from a common chiral synthon

C. Kibayashi, Nobuo Machinaga, 1992 .

Total synthesis of (+)-decarestrictine L

C. Kibayashi, Nobuo Machinaga, 1993 .

A concise synthesis of a very late antigen-4 antagonist trans-4-[1-[[2,5-dichloro-4-(1-methyl-3-indolylcarboxyamide)phenyl]acetyl]-(4S)-methoxy-(2S)-pyrrolidinylmethoxy]cyclohexanecarboxylic acid via reductive etherification.

J. Chiba, Fumihito Muro, Nobuo Machinaga, 2012, Chemical & pharmaceutical bulletin.

Preparation of macrodiolides via a common chiral building block. Total synthesis of (−)-pyrenophorin and (−)-pyrenophorol

C. Kibayashi, Nobuo Machinaga, 1993 .

Identified a morpholinyl-4-piperidinylacetic acid derivative as a potent oral active VLA-4 antagonist.

J. Chiba, M. Yokoyama, J. Baldwin, 2005, Bioorganic & medicinal chemistry letters.

Enantiodivergent total synthesis of naturally occurring trans-2-butyl-5-pentylpyrrolidine

Nobuo Machinaga, C. Kibayashi, 1990 .

Component of Caramel Food Coloring, THI, Causes Lymphopenia Indirectly via a Key Metabolic Intermediate.

Y. Kita, J. Chiba, K. Hagihara, 2016, Cell chemical biology.

Sphingosine 1-phosphate lyase inhibition by 2-acetyl-4-(tetrahydroxybutyl)imidazole (THI) under conditions of vitamin B6 deficiency

Ryuji Hashimoto, Fumihito Muro, Nobuo Machinaga, 2015, Molecular and Cellular Biochemistry.

Derive d'ethynylthiazole

Nobuo Machinaga, Toshiyuki Takeda, H. Yamaguchi, 1996 .

Discovery of a novel bicyclic compound, DS54360155, as an orally potent analgesic without mu-opioid receptor agonist activity.

K. Shimada, Nobuo Machinaga, Y. Domon, 2019, Bioorganic & medicinal chemistry letters.

Discovery of conolidine derivative DS39201083 as a potent novel analgesic without mu opioid agonist activity.

K. Shimada, Nobuo Machinaga, Y. Domon, 2019, Bioorganic & medicinal chemistry letters.

TOTAL SYNTHESIS OF (-)-VERMICULINE

C. Kibayashi, Nobuo Machinaga, S. Aoyagi, 1994 .

Sphingosine 1-phosphate lyase inhibition by 2-acetyl-4-(tetrahydroxybutyl)imidazole (THI) under conditions of vitamin B6 deficiency

Ryuji Hashimoto, Fumihito Muro, Nobuo Machinaga, 2014, Molecular and Cellular Biochemistry.