Kei-ichi Nakayama

发表

Accelerated Neutrophil Apoptosis in Mice Lacking A1-a, a Subtype of the bcl-2–related A1 Gene

K. Nakayama, N. Ishida, S. Hatakeyama, 1998, Journal of Experimental Medicine.

Down-Regulation of p27 Expression Is Required for Development and Function of T Cells

M. Kitagawa, Y. A. Minamishima, K. Nakayama, 2000 .

Aldehyde dehydrogenase (ALDH) 2 associates with oxidation of methoxyacetaldehyde; in vitro analysis with liver subcellular fraction derived from human and Aldh2 gene targeting mouse

K. Kitagawa, T. Kawamoto, A. Yoshida, 2000, FEBS letters.

Loss of Protein Kinase C-δ Protects against LPS-Induced Osteolysis Owing to an Intrinsic Defect in Osteoclastic Bone Resorption

K. Nakayama, N. Pavlos, Jiake Xu, 2013, PloS one.

Impaired germ cell development due to compromised cell cycle progression in Skp2-deficient mice

K. Nakayama, A. Fotovati, Kei-ichi Nakayama, 2006, Cell Division.

Mice Lacking p27 Kip1 Display Increased Body Size, Multiple Organ Hyperplasia, Retinal Dysplasia, and Pituitary Tumors

Nobuyuki Shishido, Ikuo Horii, Tomoaki Inoue, 1996, Cell.

nPKCε, a P2Y2-R downstream effector in regulated mucin secretion from airway goblet cells

K. Nakayama, K. Nakayama, J. Olsen, 2007 .

Cyclin D2 Translocates p27 out of the Nucleus and Promotes Its Degradation at the G0-G1 Transition

E. Susaki, K. Nakayama, Kei-ichi Nakayama, 2007, Molecular and Cellular Biology.

Mouse Fbw7/Sel-10/Cdc4 Is Required for Notch Degradation during Vascular Development*

Y. Bessho, R. Kageyama, K. Nakayama, 2004, Journal of Biological Chemistry.

Diminished alcohol preference in transgenic mice lacking aldehyde dehydrogenase activity.

K. Kitagawa, A. Matsumoto, T. Oyama, 2002, Pharmacogenetics.

Up-regulation of GPR48 induced by down-regulation of p27Kip1 enhances carcinoma cell invasiveness and metastasis.

M. Kitagawa, K. Kitagawa, K. Nakayama, 2006, Cancer research.

Essential role for ZAP-70 in both positive and negative selection of thymocytes

K. Nakayama, K. Nakayama, D. Loh, 1995, Nature.

Conditional inactivation of Fbxw7 impairs cell-cycle exit during T cell differentiation and results in lymphomatogenesis

Akinobu Matsumoto, K. Nakayama, R. Tsunematsu, 2007, The Journal of experimental medicine.

Phosphorylation‐dependent degradation of c‐Myc is mediated by the F‐box protein Fbw7

K. Nakayama, Masaaki Nishiyama, T. Kamura, 2004, The EMBO journal.

Phosphorylation at Serine 10, a Major Phosphorylation Site of p27 Kip1 , Increases Its Protein Stability*

M. Kitagawa, N. Ishida, S. Hatakeyama, 2000, The Journal of Biological Chemistry.

Common Pathway for the Ubiquitination of IκBα, IκBβ, and IκBε Mediated by the F-Box Protein FWD1*

K. Nakayama, K. Nakayama, S. Hatakeyama, 1999, The Journal of Biological Chemistry.

p57KIP2 Modulates Stress-activated Signaling by Inhibiting c-Jun NH2-terminal Kinase/Stress-activated Protein Kinase*

K. Nakayama, K. Nakayama, S. Eom, 2003, Journal of Biological Chemistry.

Down-regulation of p27 Kip1 by Two Mechanisms, Ubiquitin-mediated Degradation and Proteolytic Processing*

M. Kitagawa, C. Miyamoto, N. Ishida, 1999, The Journal of Biological Chemistry.

Skp2 is required for survival of aberrantly proliferating Rb1-deficient cells and for tumorigenesis in Rb1+/− mice

Joseph Locker, Peng Ji, K. Nakayama, 2010, Nature Genetics.

Degradation of p57Kip2 mediated by SCFSkp2-dependent ubiquitylation

K. Nakayama, T. Kamura, Shuhei Kotoshiba, 2003, Proceedings of the National Academy of Sciences of the United States of America.

SCF(Fbw7) modulates the NFkB signaling pathway by targeting NFkB2 for ubiquitination and destruction.

S. Gygi, Akinobu Matsumoto, Wenyi Wei, 2012, Cell reports.

A novel route for connexin 43 to inhibit cell proliferation: negative regulation of S-phase kinase-associated protein (Skp 2).

K. Nakayama, K. Nakayama, I. Morita, 2003, Cancer research.

Skp2 deletion unmasks a p27 safeguard that blocks tumorigenesis in the absence of pRb and p53 tumor suppressors.

K. Nakayama, J. Locker, Zhonglei Lu, 2013, Cancer cell.

Clinical and biological significance of S-phase kinase-associated protein 2 (Skp2) gene expression in gastric carcinoma: modulation of malignant phenotype by Skp2 overexpression, possibly via p27 proteolysis.

M. Mori, H. Inoue, Y. Yoshikawa, 2002, Cancer research.

Targeted disruption of Skp2 results in accumulation of cyclin E and p27Kip1, polyploidy and centrosome overduplication

M. Kitagawa, K. Kitagawa, Y. A. Minamishima, 2000, The EMBO journal.

The ISG15 Isopeptidase UBP43 Is Regulated by Proteolysis via the SCFSkp2 Ubiquitin Ligase*

C. Berset, Dong-er Zhang, S. Lanker, 2004, Journal of Biological Chemistry.

Noncanonical Wnt signaling through G protein-linked PKCdelta activation promotes bone formation.

A. McMahon, K. Nakayama, K. Nakayama, 2007, Developmental cell.

A functional link between Wnt signaling and SKP2-independent p27 turnover in mammary tumors.

K. Nakayama, J. Zack, Z. Galic, 2008, Genes & development.

Interaction between Cyclin T1 and SCFSKP2 Targets CDK9 for Ubiquitination and Degradation by the Proteasome

J. Labbé, A. Castro, T. Lorca, 2001, Molecular and Cellular Biology.

Peroxisome biogenesis deficiency attenuates the BDNF-TrkB pathway-mediated development of the cerebellum

K. Nakayama, T. Yamashita, Y. Fujiki, 2018, Life Science Alliance.

Regulation of APC/CCdc20 activity by RASSF1A–APC/CCdc20 circuitry

C. Chow, K. Lo, Kei-ichi Nakayama, 2011, Oncogene.

B. Ma, K. Nakayama, R. Homer, 2005, The Journal of clinical investigation.

Ubiquitylation of RAG-2 by Skp2-SCF links destruction of the V(D)J recombinase to the cell cycle.

S. Desiderio, A. Ross, Hao Jiang, 2005, Molecular cell.

Essential role of Skp2-mediated p27 degradation in growth and adaptive expansion of pancreatic beta cells.

Senta Georgia, A. Bhushan, S. Tschen, 2007, The Journal of clinical investigation.

Impaired degradation of inhibitory subunit of NF-κB (IκB) and β-catenin as a result of targeted disruption of the β-TrCP1 gene

K. Nakayama, S. Hatakeyama, A. Kikuchi, 2003, Proceedings of the National Academy of Sciences of the United States of America.

Involvement of p27(KIP1) degradation by Skp2 in the regulation of proliferation in response to wounding of corneal epithelium.

K. Nakayama, K. Nakayama, Kazuhiko Yoshida, 2002, Investigative ophthalmology & visual science.

Cytoplasmic ubiquitin ligase KPC regulates proteolysis of p27Kip1 at G1 phase

K. Nakayama, K. Nakayama, T. Kamura, 2004, Nature Cell Biology.

Double knockout mice show BASH and PKCdelta have different epistatic relationships in B cell maturation and CD40-mediated activation.

K. Nakayama, K. Hayashi, D. Kitamura, 2006, Immunology letters.

Role of the PLC‐related, catalytically inactive protein p130 in GABAA receptor function

I. Jang, N. Akaike, M. Matsuda, 2002, The EMBO journal.

The Cyclin-dependent Kinase Inhibitors p57 and p27 Regulate Neuronal Migration in the Developing Mouse Neocortex*

K. Nakayama, N. Masuyama, Y. Gotoh, 2007, Journal of Biological Chemistry.

Down-Regulation of p27Kip1 Expression Is Required for Development and Function of T Cells1

M. Kitagawa, Y. A. Minamishima, N. Ishida, 2001, The Journal of Immunology.

Two E3 ubiquitin ligases, SCF‐Skp2 and DDB1‐Cul4, target human Cdt1 for proteolysis

K. Nakayama, K. Nakayama, C. Obuse, 2006, The EMBO journal.

Role of Serine 10 Phosphorylation in p27 Stabilization Revealed by Analysis of p27 Knock-in Mice Harboring a Serine 10 Mutation*

Y. Kotake, K. Nakayama, N. Ishida, 2005, Journal of Biological Chemistry.

Skp2-mediated degradation of p27 regulates progression into mitosis.

Tohru Natsume, Keiichi I Nakayama, Masatoshi Kitagawa, 2004, Developmental cell.

Asbestos-induced peribronchiolar cell proliferation and cytokine production are attenuated in lungs of protein kinase C-delta knockout mice.

K. Nakayama, K. Nakayama, D. Taatjes, 2007, The American journal of pathology.

Development of mice without Cip/Kip CDK inhibitors.

Akinobu Matsumoto, K. Nakayama, K. Nakayama, 2012, Biochemical and biophysical research communications.

Deficient p27 Phosphorylation at Serine 10 Increases Macrophage Foam Cell Formation and Aggravates Atherosclerosis Through a Proliferation-Independent Mechanism

A. Diez-Juan, K. Nakayama, K. Nakayama, 2011, Arteriosclerosis, thrombosis, and vascular biology.

Phosphorylation of p27 Kip1 on Serine 10 Is Required for Its Binding to CRM1 and Nuclear Export*

K. Nakayama, K. Nakayama, T. Kamura, 2002, The Journal of Biological Chemistry.

Characterization of the mouse gene for the U-box-type ubiquitin ligase UFD2a.

K. Nakayama, M. Matsumoto, S. Hatakeyama, 2003, Biochemical and biophysical research communications.

Renal damage in obstructive nephropathy is decreased in Skp2-deficient mice.

M. Kitagawa, K. Kitagawa, K. Nakayama, 2007, The American journal of pathology.

Cell cycle-dependent regulation of the Skp2 promoter by GA-binding protein.

M. Kitagawa, H. Handa, K. Nakayama, 2003, Cancer research.

The role of {beta}-TrCP1 and {beta}-TrCP2 in circadian rhythm generation by mediating degradation of clock protein PER2.

K. Oishi, N. Ishida, K. Nakayama, 2008, Journal of biochemistry.

Recovery of liver mass without proliferation of hepatocytes after partial hepatectomy in Skp2-deficient mice.

Y. A. Minamishima, K. Nakayama, K. Nakayama, 2002, Cancer research.

Mammalian E4 Is Required for Cardiac Development and Maintenance of the Nervous System

K. Nakayama, K. Nakayama, M. Matsumoto, 2005, Molecular and Cellular Biology.

Human synovial sarcoma proto-oncogene Syt is essential for early embryonic development through the regulation of cell migration

M. Ladanyi, K. Nakayama, K. Nakayama, 2009, Laboratory Investigation.

PKC&dgr; Is Necessary for Smad3 Expression and Transforming Growth Factor β–Induced Fibronectin Synthesis in Vascular Smooth Muscle Cells

Evan J Ryer, P. Faries, K. Kent, 2006 .

Deregulation of the p57-E2F1-p53 Axis Results in Nonobstructive Hydrocephalus and Cerebellar Malformation in Mice

Akinobu Matsumoto, E. Susaki, K. Nakayama, 2011, Molecular and Cellular Biology.

Phosphorylation of p27(KIP1) in the developing retina and retinoblastoma.

K. Nakayama, S. Kase, Kazuhiko Yoshida, 2005, International Journal of Molecular Medicine.

The Papillomavirus E7 Oncoprotein Is Ubiquitinated by UbcH7 and Cullin 1- and Skp2-Containing E3 Ligase

K. Nakayama, Jing Wang, A. Kalinina, 2004, Journal of Virology.

Early Embryonic Death in Mice Lacking the β-Catenin-Binding Protein Duplin

K. Nakayama, K. Nakayama, Masaaki Nishiyama, 2004, Molecular and Cellular Biology.

Tyk2 plays a restricted role in IFN alpha signaling, although it is required for IL-12-mediated T cell function.

M. Shibamori, K. Nakayama, K. Kato, 2000, Immunity.

Multiple gene duplication and expression of mouse bcl-2-related genes, A1.

D. Loh, K. Nakayama, S. Hatakeyama, 1998, International immunology.

Regulation of the cell cycle at the G1-S transition by proteolysis of cyclin E and p27Kip1.

K. Nakayama, S. Hatakeyama, K. Nakayama, 2001, Biochemical and biophysical research communications.

Aberrant cell cycle checkpoint function and early embryonic death in Chk1(-/-) mice.

Y. A. Minamishima, K. Nakayama, M. Nakanishi, 2000, Genes & development.

Mice lacking a CDK inhibitor, p57Kip2, exhibit skeletal abnormalities and growth retardation.

K. Nakayama, Katsuhiko Takahashi, K. Takahashi, 2000, Journal of biochemistry.

SCFβTrCP1 Activates and Ubiquitylates TAp63γ*

K. Nakayama, K. Nakayama, Hua Lu, 2008, Journal of Biological Chemistry.

Distribution of p27(KIP1), cyclin D1, and proliferating cell nuclear antigen after retinal detachment

K. Nakayama, K. Nakayama, S. Kase, 2004, Graefe's Archive for Clinical and Experimental Ophthalmology.

Spatial and temporal expression patterns of the cyclin-dependent kinase (CDK) inhibitors p27 Kip1 and p57 Kip2 during mouse development

S. Hatakeyama, K. Nakayama, H. Nagahama, 2001, Anatomy and Embryology.

p27 is regulated independently of Skp2 in the absence of Cdk2.

Keiichi I Nakayama, K. Nakayama, K. Nakayama, 2014, Biochimica et biophysica acta.

p107 inhibits G1 to S phase progression by down-regulating expression of the F-box protein Skp2

K. Nakayama, S. Meloche, G. Rodier, 2005, The Journal of cell biology.

Fbxw7 regulates lipid metabolism and cell fate decisions in the mouse liver.

Akinobu Matsumoto, K. Nakayama, K. Nakayama, 2011, The Journal of clinical investigation.