V. Sabourin

发表

The Shc1 adaptor simultaneously balances Stat1 and Stat3 activity to promote breast cancer immune suppression

Tony Pawson, Claudia L. Kleinman, T. Pawson, 2017, Nature Communications.

p66ShcA functions as a contextual promoter of breast cancer metastasis

J. Ursini-Siegel, P. Siegel, I. Watson, 2020, Breast Cancer Research.

The ShcA PTB domain functions as a biological sensor of phosphotyrosine signaling during breast cancer progression.

T. Pawson, M. Hallett, J. Ursini-Siegel, 2013, Cancer research.

p66ShcA Promotes Breast Cancer Plasticity by Inducing an Epithelial-to-Mesenchymal Transition

Morag Park, M. Hallett, J. Ursini-Siegel, 2014, Molecular and Cellular Biology.

STAT1 potentiates oxidative stress revealing a targetable vulnerability that increases phenformin efficacy in breast cancer

J. Ursini-Siegel, C. Chabot, C. Kleinman, 2021, Nature Communications.

The ShcA adaptor activates AKT signaling to potentiate breast tumor angiogenesis by stimulating VEGF mRNA translation in a 4E-BP-dependent manner

T. Pawson, N. Sonenberg, J. Ursini-Siegel, 2014, Oncogene.

Integration of Distinct ShcA Signaling Complexes Promotes Breast Tumor Growth and Tyrosine Kinase Inhibitor Resistance

J. Ursini-Siegel, W. Muller, C. Kleinman, 2018, Molecular Cancer Research.

Inducing an Epithelial to Mesenchymal Transition

Julie, M. Hallett, J. Ursini-Siegel, 2014 .

Tungsten targets the tumor microenvironment to enhance breast cancer metastasis.

J. Ursini-Siegel, K. Mann, A. Bolt, 2015, Toxicological sciences : an official journal of the Society of Toxicology.

Interplay between ShcA Signaling and PGC-1α Triggers Targetable Metabolic Vulnerabilities in Breast Cancer.

T. Pawson, J. Ursini-Siegel, M. Pollak, 2018, Cancer research.

A second-generation eIF4A RNA helicase inhibitor exploits translational reprogramming as a vulnerability in triple-negative breast cancer

R. Cencic, A. Koromilas, T. Schmeing, 2024, Proceedings of the National Academy of Sciences of the United States of America.

p66ShcA promotes malignant breast cancer phenotypes by alleviating energetic and oxidative stress

C. Kleinman, S. Hébert, D. Avizonis, 2024, Redox biology.