Y. K. Im

The Shc1 adaptor simultaneously balances Stat1 and Stat3 activity to promote breast cancer immune suppression

Tony Pawson, Claudia L. Kleinman, T. Pawson, 2017, Nature Communications.

The ShcA PTB domain functions as a biological sensor of phosphotyrosine signaling during breast cancer progression.

T. Pawson, M. Hallett, J. Ursini-Siegel, 2013, Cancer research.

STAT1 potentiates oxidative stress revealing a targetable vulnerability that increases phenformin efficacy in breast cancer

J. Ursini-Siegel, C. Chabot, C. Kleinman, 2021, Nature Communications.

The ShcA adaptor activates AKT signaling to potentiate breast tumor angiogenesis by stimulating VEGF mRNA translation in a 4E-BP-dependent manner

T. Pawson, N. Sonenberg, J. Ursini-Siegel, 2014, Oncogene.

Translational and HIF1α-dependent metabolic reprograming underpin oncometabolome plasticity and synergy between oncogenic kinase inhibitors and biguanides

C. Greenwood, J. Ursini-Siegel, M. Ohh, 2017, bioRxiv.

Integration of Distinct ShcA Signaling Complexes Promotes Breast Tumor Growth and Tyrosine Kinase Inhibitor Resistance

J. Ursini-Siegel, W. Muller, C. Kleinman, 2018, Molecular Cancer Research.

Translational and HIF-1α-Dependent Metabolic Reprogramming Underpin Metabolic Plasticity and Responses to Kinase Inhibitors and Biguanides.

C. Greenwood, E. Ma, Russell G. Jones, 2018, Cell metabolism.

Interplay between ShcA Signaling and PGC-1α Triggers Targetable Metabolic Vulnerabilities in Breast Cancer.

T. Pawson, J. Ursini-Siegel, M. Pollak, 2018, Cancer research.

Translational and HIF1α-dependent metabolic reprograming underpin oncometabolome plasticity and synergy between oncogenic kinase inhibitors and biguanides

C. Greenwood, M. Ohh, O. Larsson, 2017, bioRxiv.

A second-generation eIF4A RNA helicase inhibitor exploits translational reprogramming as a vulnerability in triple-negative breast cancer

R. Cencic, A. Koromilas, T. Schmeing, 2024, Proceedings of the National Academy of Sciences of the United States of America.