Helen Gu

发表

Oxidative Metabolism of Epothilones A and B (Patupilone) by Cytochromes P450: Involvement of CYP3A and CYP2C

T. Cresteil, Hilmar Schiller, J. Mangold, 2008 .

Physiologically based pharmacokinetic modeling for assessing the clinical drug-drug interaction of alisporivir.

T. Heimbach, Imad Hanna, G. Sunkara, 2014, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Inhibition of Dengue Virus RNA Synthesis by an Adenosine Nucleoside

Yen-Liang Chen, P. Shi, W. Schul, 2010, Antimicrobial Agents and Chemotherapy.

Disposition and metabolism of [14C] Sacubitril/Valsartan (formerly LCZ696) an angiotensin receptor neprilysin inhibitor, in healthy subjects

P. Jordaan, Priya Chandra, J. Flarakos, 2016, Xenobiotica; the fate of foreign compounds in biological systems.

Evaluation of the Absorption, Metabolism, and Excretion of a Single Oral 1-mg Dose of Tropifexor in Healthy Male Subjects and the Concentration Dependence of Tropifexor Metabolism

R. Woessner, M. Kagan, M. Walles, 2021, Drug Metabolism and Disposition.

Antiviral Nucleotide Incorporation by Recombinant Human Mitochondrial RNA Polymerase Is Predictive of Increased In Vivo Mitochondrial Toxicity Risk

K. Mansfield, W. Zhong, M. Fenaux, 2016, Antimicrobial Agents and Chemotherapy.

Drug Interaction Potential of Osilodrostat (LCI699) Based on Its Effect on the Pharmacokinetics of Probe Drugs of Cytochrome P450 Enzymes in Healthy Adults

N. Sauter, L. Ting, C. Darstein, 2017, Clinical Drug Investigation.

N-Alkyl Urea Hydroxamic Acids as a New Class of Peptide Deformylase Inhibitors with Antibacterial Activity

J. Koehn, D. Patel, P. Margolis, 2002, Antimicrobial Agents and Chemotherapy.

Evaluation of Clinical Drug Interaction Potential of Clofazimine Using Static and Dynamic Modeling Approaches

H. Einolf, Helen Gu, D. Y. Chun, 2018, Drug Metabolism and Disposition.

Pharmacokinetics and metabolism of lumiracoxib in healthy male subjects.

C. Rordorf, J. Mangold, L. Rodriguez, 2004, Drug metabolism and disposition: the biological fate of chemicals.

Absorption, Metabolism, and Excretion of [14C]Vildagliptin, a Novel Dipeptidyl Peptidase 4 Inhibitor, in Humans

V. Fischer, J. Mangold, D. Howard, 2009, Drug Metabolism and Disposition.

Midostaurin, a Novel Protein Kinase Inhibitor for the Treatment of Acute Myelogenous Leukemia: Insights from Human Absorption, Metabolism, and Excretion Studies of a BDDCS II Drug

V. Tedesco, T. Heimbach, Jin Zhang, 2017, Drug Metabolism and Disposition.

Clinical disposition, metabolism and in vitro drug–drug interaction properties of omadacycline

Imad Hanna, J. Flarakos, J. Mangold, 2017, Xenobiotica; the fate of foreign compounds in biological systems.

Simultaneous Physiologically Based Pharmacokinetic (PBPK) Modeling of Parent and Active Metabolites to Investigate Complex CYP3A4 Drug-Drug Interaction Potential: A Case Example of Midostaurin

Heidi J Einolf, T. Ouatas, S. Rebello, 2018, Drug Metabolism and Disposition.

Physiologically Based Pharmacokinetic Model Predictions of Panobinostat (LBH589) as a Victim and Perpetrator of Drug-Drug Interactions

Heidi J Einolf, Handan He, J. Mangold, 2017, Drug Metabolism and Disposition.

Physiologically-based pharmacokinetic model predictions of panobinostat ( LBH 589 ) as a victim and perpetrator of drug-drug interactions

Wen Lin, H. Einolf, Christina S. Won, 2017 .

Identification of Three Novel Ring Expansion Metabolites of KAE609, a New Spiroindolone Agent for the Treatment of Malaria, in Rats, Dogs, and Humans

J. Mangold, O. Simon, H. Einolf, 2016, Drug Metabolism and Disposition.

Time‐Dependent Inhibition and Induction of Human Cytochrome P4503A4/5 by an Oral IAP Antagonist, LCL161, In Vitro and In Vivo in Healthy Subjects

Suman Sen, S. Dhuria, J. Mangold, 2013, Journal of clinical pharmacology.

Estimation of fractions metabolized by hepatic CYP enzymes using a concept of inter-system extrapolation factors (ISEFs) – a comparison with the chemical inhibition method

T. Heimbach, Hilmar Schiller, K. Umehara, 2017, Drug metabolism and personalized therapy.