T. Moore

发表

Synthesis and Evaluation of Noncovalent Naphthalene-Based KEAP1-NRF2 Inhibitors.

K. Ratia, P. R. Lazzara, Atul D. Jain, 2020, ACS medicinal chemistry letters.

Discovering Small‐Molecule Estrogen Receptor α/Coactivator Binding Inhibitors: High‐Throughput Screening, Ligand Development, and Models for Enhanced Potency

J. Snyder, J. Katzenellenbogen, H. Fu, 2011, ChemMedChem.

Amphipathic benzenes are designed inhibitors of the estrogen receptor alpha/steroid receptor coactivator interaction.

J. Katzenellenbogen, M. Collins, J. R. Gunther, 2008, ACS chemical biology.

Recent structural advances in constrained helical peptides

Kornelia J. Skowron, T. Moore, T. Speltz, 2018, Medicinal research reviews.

Scaffold-hopping as a strategy to address metabolic liabilities of aromatic compounds.

P. R. Lazzara, T. Moore, 2020, RSC medicinal chemistry.

Monocarbonyl curcumin analogues: heterocyclic pleiotropic kinase inhibitors that mediate anticancer properties.

J. Snyder, A. Prussia, H. Shim, 2013, Journal of medicinal chemistry.

Discovery of a microbially produced small molecule in a host-specific organ

Katherine E. Zink, Mark J. Mandel, Laura M. Sanchez, 2020, bioRxiv.

Probing the structural requirements of non-electrophilic naphthalene-based Nrf2 activators.

Laura J. Kingsley, A. Mesecar, J. Luciano, 2015, European journal of medicinal chemistry.

Time-Gated Luminescence Detection of Enzymatically Produced Hydrogen Sulfide: Design, Synthesis, and Application of a Lanthanide-Based Probe.

G. Thatcher, Lawrence W. Miller, Yao Yao, 2018, Inorganic chemistry.

Inhibition of the NF-κB signaling pathway by the curcumin analog, 3,5-Bis(2-pyridinylmethylidene)-4-piperidone (EF31): anti-inflammatory and anti-cancer properties.

J. Snyder, A. Marcus, H. Shim, 2012, International immunopharmacology.

Using Tumor Explants for Imaging Mass Spectrometry Visualization of Unlabeled Peptides and Small Molecules.

J. Frasor, J. Wolff, Laura M. Sanchez, 2018, ACS medicinal chemistry letters.

Synthesis and Metabolic Studies of Host Directed Inhibitors for Anti Viral Therapy.

J. Snyder, A. Prussia, P. Thepchatri, 2013, ACS medicinal chemistry letters.

Time-Gated Detection of Cystathionine γ-Lyase Activity and Inhibition with a Selective, Luminogenic Hydrogen Sulfide Sensor.

G. Thatcher, Lawrence W. Miller, K. Ratia, 2017, Chemistry.

SAR Study on Estrogen Receptor α/β Activity of (Iso)flavonoids: Importance of Prenylation, C-Ring (Un)Saturation, and Hydroxyl Substituents.

J. Bolton, B. Dietz, G. Vollmer, 2020, Journal of agricultural and food chemistry.

Replacement of a Naphthalene Scaffold in Kelch-like ECH-Associated Protein 1 (KEAP1)/Nuclear Factor (Erythroid-derived 2)-like 2 (NRF2) Inhibitors.

Haranatha R. Potteti, Aleksej Krunic, P. R. Lazzara, 2018, Journal of medicinal chemistry.

Selective Human Estrogen Receptor Partial Agonists (ShERPAs) for Tamoxifen-Resistant Breast Cancer.

J. Katzenellenbogen, G. Thatcher, D. Tonetti, 2016, Journal of medicinal chemistry.

A Set of Time-Resolved Fluorescence Resonance Energy Transfer Assays for the Discovery of Inhibitors of Estrogen Receptor-Coactivator Binding

R. Dingledine, J. Katzenellenbogen, H. Fu, 2009, Journal of biomolecular screening.

Visualizing cancer and response to therapy in vivo using Cy5.5-labeled factor VIIa and anti-tissue factor antibody

J. Ndungu, J. Snyder, D. Brat, 2015, Journal of drug targeting.

An Innovation 10 Years in the Making: The Stories in the Pages of ACS Medicinal Chemistry Letters.

G. La Regina, W. Pomerantz, Zhengqiu Li, 2022, ACS medicinal chemistry letters.

Liver S9 Fraction-Derived Metabolites of Curcumin Analogue UBS109.

J. Snyder, Shijun Zhu, M. Shoji, 2014, ACS medicinal chemistry letters.

A Small Molecule Coordinates Symbiotic Behaviors in a Host Organ

Katherine E. Zink, Mark J. Mandel, Laura M. Sanchez, 2021, mBio.

Antiviral Atropisomers: Conformational Energy Surfaces by NMR for Host-Directed Myxovirus Blockers

Gordon Wells, James P. Snyder, Aiming Sun, 2014, J. Chem. Inf. Model..

Minireview: Not picking pockets: nuclear receptor alternate-site modulators (NRAMs).

J. Katzenellenbogen, C. Mayne, T. Moore, 2010, Molecular endocrinology.

Asymmetric synthesis of host-directed inhibitors of myxoviruses

J. Ndungu, J. Snyder, P. Thepchatri, 2013, Beilstein journal of organic chemistry.

Molecular basis for the disruption of Keap1–Nrf2 interaction via Hinge & Latch mechanism

T. Mizushima, Takafumi Suzuki, Masayuki Yamamoto, 2021, Communications biology.

Tumor Angiogenesis Therapy Using Targeted Delivery of Paclitaxel to the Vasculature of Breast Cancer Metastases

Daniel J Brat, Aiming Sun, James P Snyder, 2014, Journal of drug delivery.

Steroid receptor/coactivator binding inhibitors: An update

P. R. Lazzara, Kornelia J. Skowron, B. P. David, 2019, Molecular and Cellular Endocrinology.

Chapter 21 Inhibitors of Nuclear Hormone Receptor/Coactivator Interactions

J. Katzenellenbogen, T. Moore, 2009 .

Estrogen receptor alpha/co-activator interaction assay: TR-FRET.

J. Katzenellenbogen, J. R. Gunther, T. Moore, 2015, Methods in molecular biology.

Probing the topological tolerance of multimeric protein interactions: evaluation of an estrogen/synthetic ligand for FK506 binding protein conjugate.

J. Katzenellenbogen, J. R. Gunther, T. Moore, 2010, Bioconjugate chemistry.

A Cell-Permeable Stapled Peptide Inhibitor of the Estrogen Receptor/Coactivator Interaction.

J. Frasor, Jeanne M. Danes, J. Stender, 2018, ACS chemical biology.

Novel curcumin analogue UBS109 potently stimulates osteoblastogenesis and suppresses osteoclastogenesis: involvement in Smad activation and NF-κB inhibition.

J. Snyder, M. Shoji, Aiming Sun, 2012, Integrative biology : quantitative biosciences from nano to macro.

Synthetic curcumin analog EF31 inhibits the growth of head and neck squamous cell carcinoma xenografts.

J. Snyder, G. Sica, F. Khuri, 2012, Integrative biology : quantitative biosciences from nano to macro.

A recombinant Cedar virus based high-throughput screening assay for henipavirus antiviral discovery.

C. Broder, Lijun Rong, R. Cattaneo, 2021, Antiviral research.

Charting the sequence-activity landscape of peptide inhibitors of translation termination

D. Klepacki, A. Mankin, N. Vázquez-Laslop, 2021, Proceedings of the National Academy of Sciences.

Isoquinoline Kelch-like ECH-Associated Protein 1-Nuclear Factor (Erythroid-derived 2)-like 2 (KEAP1-NRF2) Inhibitors with High Metabolic Stability.

K. Ratia, A. Ankireddy, P. R. Lazzara, 2019, Journal of medicinal chemistry.

Stapled Peptides with γ-Methylated Hydrocarbon Chains for the Estrogen Receptor/Coactivator Interaction.

E. Tajkhorshid, G. Greene, S. Fanning, 2016, Angewandte Chemie.

The isoquinoline PRL-295 increases the thermostability of Keap1 and disrupts its interaction with Nrf2

Takafumi Suzuki, Masayuki Yamamoto, Sharadha Dayalan Naidu, 2021, iScience.

Detection of thermal shift in cellular Keap1 by protein-protein interaction inhibitors using immunoblot- and fluorescence microplate-based assays

A. Dinkova-Kostova, S. Dayalan Naidu, D. Dikovskaya, 2022, STAR protocols.

Non-electrophilic modulators of the canonical Keap1/Nrf2 pathway.

B. Richardson, T. Moore, A. D. Jain, 2015, Bioorganic & medicinal chemistry letters.

A "cross-stitched" peptide with improved helicity and proteolytic stability.

E. Tajkhorshid, G. Greene, S. Fanning, 2018, Organic & biomolecular chemistry.

Mapping the energy landscape of PROTAC-mediated protein-protein interactions

Michael E. Johnson, Tasneem M. Vaid, T. Moore, 2021, bioRxiv.

Structure-Activity Relationships of the Antimicrobial Peptide Natural Product Apidaecin.

D. Klepacki, A. Mankin, Y. Polikanov, 2023, Journal of medicinal chemistry.

Peptide-Drug Conjugates: An Emerging Direction for the Next Generation of Peptide Therapeutics.

T. Moore, Trevor T Dean, A'Lester C Allen, 2024, Journal of medicinal chemistry.

N-Substituted Pyrrole-Based Heterocycles as Broad-Spectrum Filoviral Entry Inhibitors.

N. Peet, J. J. Patten, T. Moore, 2024, Journal of medicinal chemistry.

An orally active entry inhibitor of influenza A viruses protects mice and synergizes with oseltamivir and baloxavir marboxil

Lijun Rong, Ping Li, Ruikun Du, 2024, Science advances.