T. Brooks

发表

Discovery and functional evaluation of diverse novel human CB(1) receptor ligands.

Nicolas Foloppe, N. Foloppe, G. Kennett, 2009, Bioorganic & medicinal chemistry letters.

Cell Cycle and Senescence Knockdown of PAK 4 or PAK 1 Inhibits the Proliferation of Mutant KRAS Colon Cancer Cells Independently of RAF / MEK / ERK and PI 3 K / AKT Signaling

A. Massey, T. Brooks, Hana Tabusa, 2012 .

Knockdown of PAK4 or PAK1 Inhibits the Proliferation of Mutant KRAS Colon Cancer Cells Independently of RAF/MEK/ERK and PI3K/AKT Signaling

A. Massey, T. Brooks, Hana Tabusa, 2012, Molecular Cancer Research.

Fatty acid amide hydrolase inhibitors. Surprising selectivity of chiral azetidine ureas.

Melanie H. Wong, S. Lightowler, G. Kennett, 2009, Bioorganic & medicinal chemistry letters.

XR5967, a novel modulator of plasminogen activator inhibitor-1 activity, suppresses tumor cell invasion and angiogenesis in vitro

N. Brünner, P. Charlton, Shouming Wang, 2004, Anti-cancer drugs.

Novel inhibitors of plasminogen activator inhibitor-1: development of new templates from diketopiperazines.

S. Wren, P. Charlton, J. Golec, 2002, Bioorganic & medicinal chemistry letters.

Synthesis and in vitro evaluation of a series of diketopiperazine inhibitors of plasminogen activator inhibitor-1.

P. Charlton, J. Golec, A. Folkes, 2001, Bioorganic & medicinal chemistry letters.

Antibodies to PAI-1 alter the invasive and migratory properties of human tumour cells in vitro

P. Quax, P. Charlton, J. Verheijen, 2004, Clinical & Experimental Metastasis.

Chk1 inhibition induces a DNA damage bystander effect in cocultured tumour cells.

A. Massey, J. Wayne, T. Brooks, 2021, DNA repair.

Fatty acid amide hydrolase inhibitors. 3: tetra-substituted azetidine ureas with in vivo activity.

Melanie H. Wong, S. Lightowler, G. Kennett, 2012, Bioorganic & medicinal chemistry letters.

Inhibition of Chk1 with the small molecule inhibitor V158411 induces DNA damage and cell death in an unperturbed S-phase

A. Massey, J. Wayne, T. Brooks, 2016, Oncotarget.

Discovery of a novel class of selective human CB1 inverse agonists.

Nicolas Foloppe, Stefania Leonardi, N. Foloppe, 2008, Bioorganic & medicinal chemistry letters.

Checkpoint Kinase 1 (Chk1) inhibition fails to activate the Stimulator of Interferon Genes (STING) innate immune signalling in a human coculture cancer system

A. Massey, J. Wayne, T. Brooks, 2021, Molecular Biomedicine.

Targeting DNA damage response pathways to activate the STING innate immune signaling pathway in human cancer cells

A. Massey, J. Wayne, T. Brooks, 2021, The FEBS journal.

Plasminogen Activator Inhibitor-1 Supports IL-8-Mediated Neutrophil Transendothelial Migration by Inhibition of the Constitutive Shedding of Endothelial IL-8/Heparan Sulfate/Syndecan-1 Complexes1

J. Shute, L. Marshall, T. Brooks, 2003, The Journal of Immunology.

Sulfate/Syndecan-1 Complexes Shedding of Endothelial IL-8/Heparan Migration by Inhibition of the Constitutive IL-8-Mediated Neutrophil Transendothelial Plasminogen Activator Inhibitor-1 Supports

P. Charlton, J. Shute, L. Marshall, 2003 .

Discovery and optimization of potent and selective functional antagonists of the human adenosine A2B receptor.

A. Knight, Melanie H. Wong, S. Lightowler, 2009, Bioorganic & medicinal chemistry letters.

Plasminogen Activator Inhibitor-1 Supports IL-8-Mediated Neutrophil Transendothelial Migration by Inhibition of the Constitutive Shedding of Endothelial IL-8/Heparan Sulfate/Syndecan-1 Complexes

P. Charlton, J. Shute, L. Marshall, 2003, The Journal of Immunology.