T. Focken

发表

NBI-921352, a first-in-class, NaV1.6 selective, sodium channel inhibitor that prevents seizures in Scn8a gain-of-function mice, and wild-type mice and rats

Angela Hussainkhel, S. Decker, Matthew Waldbrook, 2021, bioRxiv.

Synthesis of iridium complexes with new planar chiral chelating phosphinyl-imidazolylidene ligands and their application in asymmetric hydrogenation

C. Bolm, G. Raabe, T. Focken, 2004 .

Lewis-acid catalyzed formation of dihydropyrans

S. Hanessian, T. Focken, R. Oza, 2011 .

Total synthesis of jerangolid A.

S. Hanessian, T. Focken, R. Oza, 2010, Organic letters.

Application of cyclic phosphonamide reagents in the total synthesis of natural products and biologically active molecules

S. Hanessian, T. Focken, 2014, Beilstein journal of organic chemistry.

Stereoselective synthesis of pyridinones: application to the synthesis of (-)-barrenazines.

A. Charette, T. Focken, 2006, Organic letters.

Stereoselective Lateral Functionalization of Monosubstituted [2.2]Paracyclophanes by Directed ortho‐Metalation−Homologous Anionic Fries Rearrangement

V. Snieckus, H. Hopf, I. Dix, 2001 .

Synthesis of Chiral Cyrhetrenes and Their Application in Asymmetric Catalysis

C. Bolm, G. Raabe, Lukas Hintermann, 2004 .

Total synthesis of (+)-ambruticin S: probing the pharmacophoric subunit.

R. Beaudegnies, S. Hanessian, Dougal J. Ritson, 2010, The Journal of organic chemistry.

Synthesis of iridium complexes with novel planar chiral chelating imidazolylidene ligands

C. Bolm, G. Raabe, T. Focken, 2003 .

Design of Conformationally Constrained Acyl Sulfonamide Isosteres: Identification of N-([1,2,4]Triazolo[4,3- a]pyridin-3-yl)methane-sulfonamides as Potent and Selective hNaV1.7 Inhibitors for the Treatment of Pain.

D. Sutherlin, D. Hackos, A. D. White, 2018, Journal of medicinal chemistry.

Structural basis of Nav1.7 inhibition by an isoform-selective small-molecule antagonist

Jun Li, Christine Tam, Daniel F. Ortwine, 2015, Science.

Identification of Selective Acyl Sulfonamide-Cycloalkylether Inhibitors of the Voltage-Gated Sodium Channel (NaV) 1.7 with Potent Analgesic Activity.

Benjamin D. Sellers, D. Sutherlin, D. Hackos, 2018, Journal of medicinal chemistry.

Identification of CNS-Penetrant Aryl Sulfonamides as Isoform-Selective NaV1.6 Inhibitors with Efficacy in Mouse Models of Epilepsy.

R. DeVita, S. Decker, Matthew Waldbrook, 2019, Journal of medicinal chemistry.

Discovery of Aryl Sulfonamides as Isoform-Selective Inhibitors of NaV1.7 with Efficacy in Rodent Pain Models.

Shifeng Liu, R. Oballa, D. Sutherlin, 2016, ACS medicinal chemistry letters.

Discovery of Acyl-sulfonamide Nav1.7 Inhibitors GDC-0276 and GDC-0310.

D. Sutherlin, Jun Chen, D. Hackos, 2021, Journal of medicinal chemistry.

NaV1.6 inhibition drives the efficacy of voltage-gated sodium channel inhibitors to prevent electrically induced seizures in both wild type and Scn8aN1768D/+ gain-of-function mice

Wei Zhang, Angela Hussainkhel, Matthew Waldbrook, 2023, bioRxiv.

Molecular pharmacology of selective Nav1.6 and dual Nav1.6 and Nav1.2 channel inhibitors that suppress excitatory neuronal activity ex vivo

P. Ruben, Matthew Waldbrook, R. R. Parrish, 2023, bioRxiv.