N. Shuart

发表

NBI-921352, a first-in-class, NaV1.6 selective, sodium channel inhibitor that prevents seizures in Scn8a gain-of-function mice, and wild-type mice and rats

Angela Hussainkhel, S. Decker, Matthew Waldbrook, 2021, bioRxiv.

Biomonitoring brevetoxin exposure in mammals using blood collection cards.

M. Busman, J. Ramsdell, P. Moeller, 2001, Environmental health perspectives.

Synaptosomes as a platform for loading nanoparticles into synaptic vesicles.

Kristi L. Budzinski, Jennifer C. Gadd, D. Chiu, 2011, ACS chemical neuroscience.

Inhibitory effects of cannabidiol on voltage-dependent sodium currents

P. Ruben, S. Goodchild, R. Dean, 2018, The Journal of Biological Chemistry.

Molecular mechanism for 3:1 subunit stoichiometry of rod cyclic nucleotide-gated ion channels

W. N. Zagotta, Y. Haitin, N. Shuart, 2011, Nature communications.

Selective NaV1.7 Antagonists with Long Residence Time Show Improved Efficacy against Inflammatory and Neuropathic Pain.

D. Sutherlin, D. Hackos, S. Decker, 2018, Cell reports.

Design of Conformationally Constrained Acyl Sulfonamide Isosteres: Identification of N-([1,2,4]Triazolo[4,3- a]pyridin-3-yl)methane-sulfonamides as Potent and Selective hNaV1.7 Inhibitors for the Treatment of Pain.

D. Sutherlin, D. Hackos, A. D. White, 2018, Journal of medicinal chemistry.

Identification of CNS-Penetrant Aryl Sulfonamides as Isoform-Selective NaV1.6 Inhibitors with Efficacy in Mouse Models of Epilepsy.

R. DeVita, S. Decker, Matthew Waldbrook, 2019, Journal of medicinal chemistry.

Discovery of Aryl Sulfonamides as Isoform-Selective Inhibitors of NaV1.7 with Efficacy in Rodent Pain Models.

Shifeng Liu, R. Oballa, D. Sutherlin, 2016, ACS medicinal chemistry letters.

NaV1.6 inhibition drives the efficacy of voltage-gated sodium channel inhibitors to prevent electrically induced seizures in both wild type and Scn8aN1768D/+ gain-of-function mice

Wei Zhang, Angela Hussainkhel, Matthew Waldbrook, 2023, bioRxiv.

Molecular pharmacology of selective Nav1.6 and dual Nav1.6 and Nav1.2 channel inhibitors that suppress excitatory neuronal activity ex vivo

P. Ruben, Matthew Waldbrook, R. R. Parrish, 2023, bioRxiv.

Expanding the genotype-phenotype spectrum in SCN8A-related disorders

M. Demos, M. Hebbar, L. Armstrong, 2024, BMC neurology.

Expanding the genotype-phenotype spectrum in SCN8A-related disorders

M. Demos, M. Hebbar, M. Connolly, 2023, Research square.