Hisashi Takahashi

发表

Efficient asymmetric hydrogenation of α-aminoacetophenone derivatives leading to practical synthesis of ()-(−)-levamisole

K. Achiwa, T. Morimoto, H. Takeda, 1989 .

Novel pyridobenzimidazole derivatives exhibiting antifungal activity by the inhibition of beta-1,6-glucan synthesis.

A. Kitamura, K. Kawakami, R. Nakajima, 2010, Bioorganic & medicinal chemistry letters.

Efficient Asymmetric Hydrogenations of (Z)-2-Acetamidoacrylic Acid Derivatives with the Cationic Rhodium Complex of (2S,4S)-MOD-BPPM

K. Achiwa, Hisashi Takahashi, 1989 .

Identification of the 5,5-dioxo-7,8-dihydro-6H-thiopyrano[3,2-d]pyrimidine derivatives as highly selective PDE4B inhibitors.

Mizuki Takahashi, S. Sasaki, T. Mikkaichi, 2014, Bioorganic & medicinal chemistry letters.

Design, Synthesis, and Biological Evaluation of Novel 7-[(3 aS,7 aS)-3 a-Aminohexahydropyrano[3,4- c]pyrrol-2(3 H)-yl]-8-methoxyquinolines with Potent Antibacterial Activity against Respiratory Pathogens.

Hisashi Takahashi, T. Kitamura, S. Komoriya, 2018, Journal of medicinal chemistry.

Transition Metal Catalyzed [5 + 2] Cycloadditions of Vinylcyclopropanes and Alkynes: A Homolog of the Diels-Alder Reaction for the Synthesis of Seven-Membered Rings

P. Wender, Hisashi Takahashi, B. Witulski, 1995 .

Design, synthesis and biological evaluations of novel 7-[3-(1-aminocycloalkyl)pyrrolidin-1-yl]-6-desfluoro-8-methoxyquinolones with potent antibacterial activity against multi-drug resistant Gram-positive bacteria.

K. Kawakami, Hisashi Takahashi, H. Ohki, 2009, Bioorganic & medicinal chemistry.

Synthesis and antibacterial activity of novel 6-fluoro-1-[(1R,2S)-2-fluorocyclopropan-1-yl]-4-oxoquinoline-3-carboxylic acids bearing cyclopropane-fused 2-amino-8-azabicyclo[4.3.0]nonan-8-yl substituents at the C-7 position.

Hisashi Takahashi, H. Inagaki, M. Takemura, 2004, Bioorganic & medicinal chemistry letters.

Practical Synthesis of DQ-113, a New Quinolone Antibacterial Agent, by Using the Intramolecular Horner-Wadsworth-Emmons Reaction

K. Kawakami, Hisashi Takahashi, Toshiyuki Takeda, 2004 .

Synthesis and Structure−Activity Relationships of 5-Amino-6-fluoro-1-[(1R,2S)-2-fluorocyclopropan-1-yl]-8-methylquinolonecarboxylic Acid Antibacterials Having Fluorinated 7-[(3R)-3-(1-Aminocyclopropan-1-yl)pyrrolidin-1-yl] Substituents1

K. Kawakami, Hisashi Takahashi, H. Ohki, 2003 .

Dramatic Hydrogen Pressure and Triethylamine Effects on the Asymmetric Hydrogenation of Itaconic Acid Which Give a New Mechanistic Aspect on Asymmetric Induction

K. Achiwa, Hisashi Takahashi, 1987 .

Synthesis and application of a novel bisphosphine ligand, (−)-DIOCP, as an unsymmetrized diop to prove the general utility of new designing concept.

K. Achiwa, T. Morimoto, Hisashi Takahashi, 1987 .

Preparation of new chiral pyrrolidinebisphosphines as highly effective ligands for catalytic asymmetric synthesis of R-(−)-pantolactone

K. Achiwa, T. Morimoto, Hisashi Takahashi, 1986 .

Highly Effective Catalytic Asymmetric Hydrogenations of α-Keto Esters and an α-Keto Acetal with New Neutral Chiral Pyrrolidinebisphosphine-Rhodium Complexes

K. Achiwa, T. Morimoto, Hisashi Takahashi, 1987 .

Synthesis of a new chiral pyrrolidine ligand bearing two different types of phosphino groups and their effects on the asymmetric hydrogenation of ketopantolactone.

K. Achiwa, T. Morimoto, Hisashi Takahashi, 1986 .

Asymmetric reactions catalyzed by chiral metal complexes. 41. Highly efficient asymmetric hydrogenation of amino ketone derivatives leading to practical syntheses of (S)-propranolol and related compounds

S. Sakuraba, K. Achiwa, H. Takeda, 1990 .

The Effects of cis-Coordinating Phosphine of Chiral Bisphosphine–Rhodium Complexes on the Catalytic Activities in the Asymmetric Hydrogenation of Itaconic Acid

K. Achiwa, N. Yamamoto, H. Takeda, 1989 .

Practical asymmetric synthesis of (R)-(−)-phenylephrine hydrochloride catalyzed by (2R,4R)-MCCPM-rhodium complex

K. Achiwa, T. Morimoto, H. Takeda, 1989 .

Asymmetric reactions catalyzed by chiral metal complexes. XXXIV. The effects of cis-coordinating phosphine of chiral bisphosphine-rhodium complexes on the catalytic activities in the asymmetric hydrogenation of itaconic acid.

K. Achiwa, N. Yamamoto, H. Takeda, 1989 .

Efficient Asymmetric Hydrogenation of α-Amino Ketone Derivatives. A Highly Enantioselective Synthesis of Phenylephrine, Levamisole, Carnitine and Propranolol

S. Sakuraba, K. Achiwa, H. Takeda, 1995 .

Design, synthesis, and biological evaluations of novel 7-[7-amino-7-methyl-5-azaspiro[2.4]heptan-5-yl]-8-methoxyquinolines with potent antibacterial activity against respiratory pathogens.

Hisashi Takahashi, Y. Sugimoto, J. Kuroyanagi, 2013, Journal of medicinal chemistry.

Improved synthesis of DQ-113, a new quinolone antibacterial agent, utilizing the Reformatsky reaction

K. Sugita, Hisashi Takahashi, M. Itoh, 2003 .

Synthesis and biological evaluation of novel imidazol-1-ylacetic acid derivatives as non-brain penetrant bombesin receptor subtype-3 (BRS-3) agonists.

Y. Nagai, Yasuyuki Abe, K. Shimada, 2016, Bioorganic & medicinal chemistry letters.

Synthesis and biological evaluation of novel chiral diazepine derivatives as bombesin receptor subtype-3 (BRS-3) agonists incorporating an antedrug approach.

Y. Nagai, Yasuyuki Abe, K. Shimada, 2015, Bioorganic & medicinal chemistry.

Discovery of novel chiral diazepines as bombesin receptor subtype-3 (BRS-3) agonists with low brain penetration.

K. Shimada, Kazuhiro Yoshida, Hisashi Takahashi, 2014, Bioorganic & medicinal chemistry letters.

Novel Pyridobenzimidazole Derivatives Exhibiting Antifungal Activity by the Inhibition of β-1,6-Glucan Synthesis.

A. Kitamura, K. Kawakami, R. Nakajima, 2010 .