N. Shigematsu

发表

Fast Distinguishment of Unknown from Known Compounds. Dereplication of Natural Products Using LC/MS.

N. Shigematsu, 1997 .

Cloning and heterologous expression of P450Um-1, a novel bacterial P450 gene, for hydroxylation of immunosuppressive agent AS1387392

M. Hino, A. Fujie, N. Shigematsu, 2010, The Journal of Antibiotics.

Physiological analysis of bicozamycin high-producing Streptomyces griseoflavus used at industrial level.

K. Ochi, M. Okuhara, K. Umehara, 1988, The Journal of antibiotics.

Neamphamide A, a new HIV-inhibitory depsipeptide from the Papua New Guinea marine sponge Neamphius huxleyi.

L. Pannell, K. Gustafson, M. Boyd, 2004, Journal of natural products.

Microspinosamide, a new HIV-inhibitory cyclic depsipeptide from the marine sponge Sidonops microspinosa.

L. Pannell, K. Gustafson, M. Boyd, 2001, Journal of natural products.

Discovery of Novel Forkhead Box O1 Inhibitors for Treating Type 2 Diabetes: Improvement of Fasting Glycemia in Diabetic db/db Mice

T. Shimokawa, H. Tanaka, A. Shimaya, 2010, Molecular Pharmacology.

Site-specific structural transformation of the novel antifungal cyclic depsipeptide FR901469: synthesis and biological activity of FR203903.

A. Tanaka, A. Fujie, F. Ikeda, 2001, The Journal of antibiotics.

FR9Q1451, A NOVEL INHIBITOR OF HUMAN LEUKOCYTE ELASTASE FROM Flexibacter sp.

Kenichi Hayashi, M. Okuhara, H. Hatanaka, 1994 .

FR225659-binding proteins: identification as serine/threonine protein phosphatase PP1 and PP2A using high-performance affinity beads.

H. Handa, M. Hino, Y. Ohtsu, 2004, The Journal of antibiotics.

WS9326A, A NOVEL TACHYKININ ANTAGONIST ISOLATED

M. Okuhara, H. Imanaka, M. Kohsaka, 2006 .

FR901483, a novel immunosuppressant isolated from Cladobotryum sp. No. 11231. Taxonomy of the producing organism, fermentation, isolation, physico-chemical properties and biological activities.

M. Okuhara, K. Sakamoto, E. Tsujii, 1996, The Journal of antibiotics.

WF1 1899A, B AND C, NOVEL ANTIFUNGAL LIPOPEPTIDES I. TAXONOMY, FERMENTATION, ISOLATION AND PHYSICO-CHEMICAL PROPERTIES

Sakamoto, Seiji, Toshiro, 2006 .

WF11899A, B and C, novel antifungal lipopeptides. I. Taxonomy, fermentation, isolation and physico-chemical properties.

M. Okuhara, K. Sakamoto, A. Fujie, 1994, The Journal of antibiotics.

FR901469, a novel antifungal antibiotic from an unidentified fungus No. 11243. III. Structure determination.

A. Fujie, M. Hashimoto, S. Yoshimura, 2001, The Journal of antibiotics.

An expedient synthesis of the amide analog of the potent antifungal lipopeptidolactone FR901469

A. Tanaka, A. Fujie, D. Barrett, 2001 .

TAXONOMY OF THE PRODUCING ORGANISM, FERMENTATION, ISOLATION, PHYSICO-CHEMICAL PROPERTIES AND BIOLOGICAL ACTIVITIES

M. Okuhara, K. Sakamoto, E. Tsujii, 2006 .

FR901459, a novel immunosuppressant isolated from Stachybotrys chartarum No. 19392. Taxonomy of the producing organism, fermentation, isolation, physico-chemical properties and biological activities.

M. Okuhara, K. Sakamoto, E. Tsujii, 1993, The Journal of antibiotics.

FR901277, a novel inhibitor of human leukocyte elastase from Streptomyces resistomycificus. Producing organism, fermentation, isolation, physico-chemical and biological properties.

M. Okuhara, H. Hatanaka, M. Okamoto, 1993, The Journal of antibiotics.

Identification of 7α-hydroxy-3-oxo-4-cholestenoic acid in chronic subdural hematoma

K. Takakura, K. Nagata, Takao Shimizu, 1992 .

Biphenomycins A and B, novel peptide antibiotics. II. Structural elucidation of biphenomycins A and B.

H. Imanaka, H. Aoki, M. Hashimoto, 1985, The Journal of antibiotics.

Structure of lavendomycin, a new peptide antibiotic

M. Hashimoto, M. Ezaki, N. Shigematsu, 1985 .

Structure and synthesis of FR900490, a new immunomodulating peptide isolated from a fungus

H. Terano, N. Shigematsu, T. Shibata, 1988 .

Cytotoxic metabolites from a fungal adherent of a marine alga.

A. Numata, C. Takahashi, Y. Takai, 1995, Phytochemistry.

Papuamides A-D, HIV-inhibitory and cytotoxic depsipeptides from the sponges Theonella mirabilis and Theonella swinhoei, collected in Papua New Guinea

L. Pannell, K. Gustafson, M. Boyd, 1999 .

FR1 12123, A NEW OLIGOPEPTIDE ANTIBIOTIC FROM STREP TOM YCES VIRID O CHROMO GENES TAXONOMY, FERMENTATION, ISOLATION, PHYSICO-CHEMICAL PROPERTIES, STRUCTURE AND BIOLOGICAL ACTIVITY

M. Okuhara, H. Imanaka, A. Fujie, 2006 .

R1128 substances, novel non-steroidal estrogen-receptor antagonists produced by a Streptomyces. II. Physico-chemical properties and structure determination.

M. Okuhara, T. Goto, M. Kohsaka, 1993, The Journal of antibiotics.

FR112123, a new oligopeptide antibiotic from Streptomyces viridochromogenes. Taxonomy, fermentation, isolation, physico-chemical properties, structure and biological activity.

M. Okuhara, H. Imanaka, M. Hino, 1990, The Journal of antibiotics.

A novel antifungal antibiotic, FR-900848. I. Production, isolation, physico-chemical and biological properties.

M. Okuhara, M. Kohsaka, M. Yoshida, 1990, The Journal of antibiotics.

Biphenomycin C, a precursor of biphenomycin A in mixed culture.

H. Imanaka, M. Yamashita, K. Umehara, 1993, The Journal of antibiotics.

Structures of five components of the actinomycin Z complex from Streptomyces fradiae, two of which contain 4-chlorothreonine.

L. Pannell, A. Mauger, H. Lackner, 2000, Journal of natural products.

FR901228, a novel antitumor bicyclic depsipeptide produced by Chromobacterium violaceum No. 968. II. Structure determination.

H. Tanaka, Hirokazu Tanaka, N Shigematsu, 1994, The Journal of antibiotics.

WS-9659 A AND B, NOVEL TESTOSTERONE 5α-REDUCTASE INHIBITORS ISOLATED FROM A STREPTOMYCES

M. Kohsaka, M. Hashimoto, S. Kiyoto, 1989 .

The novel gluconeogenesis inhibitors FR225659 and FR225656 from Helicomyces sp. No. 19353. III. Structure determination.

M. Hino, Y. Ohtsu, S. Yoshimura, 2003, The Journal of antibiotics.

Structure and synthesis of an immunoactive lipopeptide, WS1279, of microbial origin.

Y. Tsuda, T. Goto, M. Hashimoto, 1991, Chemical and pharmaceutical bulletin.

Structure and synthesis of an immunoactive lipopeptide, WS1279, of microbial origin.

Y. Tsuda, M. Tanaka, T. Goto, 1990, Chemical and pharmaceutical bulletin.

WS9761 A and B: new non-steroidal androgen-receptor antagonists produced by a Streptomyces.

M. Okuhara, H. Nakajima, T. Goto, 1993, The Journal of antibiotics.

WS9326A, a novel tachykinin antagonist isolated from Streptomyces violaceusniger no. 9326. I. Taxonomy, fermentation, isolation, physico-chemical properties and biological activities.

M. Okuhara, H. Imanaka, M. Kohsaka, 1992, The Journal of antibiotics.

Structure of WS-43708A, a novel cyclic peptide antibiotic

M. Hashimoto, M. Ezaki, N. Shigematsu, 1985 .

BIPHENOMYClNS A AND B, NOVEL PEPTIDE ANTIBIOTICS II. STRUCTURAL ELUClDATION OF BIPHENOMYClNS A AND B

H. Aoki, M. Hashimoto, M. Ezaki, 2006 .

Novobiocin, an antagonist of leukotriene B4.

M. Okuhara, H. Hatanaka, M. Okamoto, 1992, The Journal of antibiotics.

WS79089A, B and C, new endothelin converting enzyme inhibitors isolated from Streptosporangium roseum. No. 79089. Taxonomy, fermentation, isolation, physico-chemical properties and biological activities.

M. Okuhara, K. Sakamoto, S. Kiyoto, 1994, The Journal of antibiotics.

Napyradiomycins A and B1: non-steroidal estrogen-receptor antagonists produced by a Streptomyces.

M. Okuhara, T. Goto, M. Kohsaka, 1993, The Journal of antibiotics.

Further phloroglucinol derivatives in the fruits of Mallotus japonicus

I. Kouno, N. Kawano, N. Shigematsu, 1985 .

II. PHYSICO-CHEMICAL PROPERTIES AND STRUCTURE DETERMINATION

Toshio, M. Okuhara, Shigehiro, 2006 .

Simultaneous assay of the activities of two key enzymes in cholesterol metabolism by gas chromatography-mass spectrometry.

N. Shigematsu, A. Honda, N. Tanaka, 1991, Journal of chromatography.

WS-9659 A and B, novel testosterone 5 alpha-reductase inhibitors isolated from a Streptomyces. II. Structural elucidation of WS-9659 A and B.

M. Kohsaka, M. Hashimoto, S. Kiyoto, 1989, The Journal of antibiotics.

Total synthesis of WS9326A, a potent tachykinin antagonist from Streptomyces violaceoniger.

H. Tanaka, S. Okada, N. Shigematsu, 1997, Chemical & pharmaceutical bulletin.