T. Asano

发表

Effects of intrathecal administration of nicardipine and nifedipine on chronic cerebral vasospasm in dogs

K. Sugita, M. Takayasu, M. Shibuya, 1994, Journal of Clinical Neuroscience.

Neuroprotective properties of a protein kinase inhibitor against ischaemia‐induced neuronal damage in rats and gerbils

H. Hidaka, M. Shibuya, Y. Suzuki, 1996, British journal of pharmacology.

Wide therapeutic time window for fasudil neuroprotection against ischemia-induced delayed neuronal death in gerbils

I. Ikegaki, Y. Toshima, M. Iwasaki, 2007, Brain Research.

Endothelin and the production of cerebral vasospasm in dogs.

M. Shibuya, Y. Suzuki, S. Satoh, 1989, Biochemical and biophysical research communications.

Endothelin: a potential modulator of cerebral vasospasm.

K. Sugita, H. Hidaka, M. Shibuya, 1990, European journal of pharmacology.

Inhibition of Rho Kinase (ROCK) Leads to Increased Cerebral Blood Flow and Stroke Protection

M. Moskowitz, Hyung-Hwan Kim, J. Liao, 2005, Stroke.

Pharmacological profile of hydroxy fasudil as a selective rho kinase inhibitor on ischemic brain damage.

T. Kobayashi, T. Utsunomiya, K. Tsurui, 2001, Life sciences.

Rho-kinase-mediated pathway induces enhanced myosin light chain phosphorylations in a swine model of coronary artery spasm.

A. Takeshita, K. Kaibuchi, H. Shimokawa, 1999, Cardiovascular research.

Antianginal effects of hydroxyfasudil, a Rho‐kinase inhibitor, in a canine model of effort angina

H. Shimokawa, T. Utsunomiya, S. Satoh, 2001, British journal of pharmacology.

Involvement of Rho-kinase in vascular remodeling caused by long-term inhibition of nitric oxide synthesis in rats.

H. Shimokawa, T. Hattori, I. Ikegaki, 2001, European journal of pharmacology.

Enhanced myosin light chain phosphorylations as a central mechanism for coronary artery spasm in a swine model with interleukin-1beta.

A. Takeshita, H. Shimokawa, K. Egashira, 1997, Circulation.

A New Model of Cerebral Microthrombosis in Rats and the Neuroprotective Effect of a Rho-Kinase Inhibitor

S. Satoh, I. Ikegaki, Y. Toshima, 2000, Stroke.

Effects of vasopressin and oxytocin on canine cerebral circulation in vivo.

K. Sugita, M. Shibuya, Y. Suzuki, 1992, Journal of neurosurgery.

Wide therapeutic time window for Rho-kinase inhibition therapy in ischemic brain damage in a rat cerebral thrombosis model

M. Seto, I. Ikegaki, Y. Toshima, 2008, Brain Research.

Amelioration of endothelial damage/dysfunction is a possible mechanism for the neuroprotective effects of Rho-kinase inhibitors against ischemic brain damage

I. Ikegaki, K. Kawasaki, T. Asano, 2010, Brain Research Bulletin.

Effect of the intracellular calcium antagonist HA1004 on cerebral blood flow in rats.

H. Hidaka, M. Shibuya, Y. Suzuki, 1988, Neurologia medico-chirurgica.

Endothelin causes contraction of canine and bovine arterial smooth muscle in vitro and in vivo

K. Sugita, O. Rorstad, M. Shibuya, 1990, Acta Neurochirurgica.

Effects of calcitonin gene-related peptide on canine cerebral artery strips and the in-vivo vertebral blood flow in dogs

K. Sugita, M. Shibuya, Yoshio Suzuki, 1989, Naunyn-Schmiedeberg's Archives of Pharmacology.

The effects of HA compound calcium antagonists on delayed cerebral vasospasm in dogs.

H. Hidaka, M. Takayasu, M. Shibuya, 1986, Journal of neurosurgery.

Fasudil attenuates interstitial fibrosis in rat kidneys with unilateral ureteral obstruction.

H. Shimokawa, K. Shiraiwa, I. Ikegaki, 2002, European journal of pharmacology.

Effects of Rho-kinase inhibitor on vasopressin-induced chronic myocardial damage in rats.

H. Shimokawa, I. Ikegaki, Y. Toshima, 2002, Life sciences.

Fasudil, a protein kinase inhibitor, prevents the development of endothelial injury and neutrophil infiltration in a two-haemorrhage canine subarachnoid model

Yasuhiro Yamamoto, M. Shibuya, Yoshio Suzuki, 1999, Journal of Clinical Neuroscience.

Long-term inhibition of Rho-kinase induces a regression of arteriosclerotic coronary lesions in a porcine model in vivo.

A. Takeshita, K. Kaibuchi, H. Shimokawa, 2001, Cardiovascular research.

Vascular alpha1-adrenoceptor subtype selectivity and alpha1-blocker-induced orthostatic hypotension.

G. Tsujimoto, K. Shibata, A. Hirasawa, 1998, Japanese journal of pharmacology.

Antiischemic properties of fasudil in experimental models of vasospastic angina.

H. Shimokawa, I. Ikegaki, T. Asano, 2001, Japanese journal of pharmacology.

Demonstration of elevation and localization of Rho-kinase activity in the brain of a rat model of cerebral infarction.

M. Seto, Kazuo Yano, T. Hattori, 2008, European journal of pharmacology.

Increased leukocyte ROCK activity in patients after acute ischemic stroke

Farzaneh A. Sorond, J. Liao, S. Feske, 2009, Brain Research.

The effects of an intracellular calcium antagonist HA 1077 on delayed cerebral vasospasm in dogs

H. Hidaka, M. Takayasu, M. Shibuya, 2005, Acta Neurochirurgica.

Blockade of intracellular actions of calcium may protect against ischaemic damage to the gerbil brain

K. Sugita, H. Hidaka, M. Shibuya, 1991, British journal of pharmacology.

Blockade ofintracellular actions ofcalcium may protectagainst ischaemic damagetothegerbil brain

H. Hidaka, D. Mochizuki, I. Ikegaki, 1991 .

The effects of HA1077 on the cerebral circulation after subarachnoid haemorrhage in dogs

K. Sugita, H. Hidaka, M. Shibuya, 2005, Acta Neurochirurgica.

Antivasospastic effects of hydroxyfasudil, a Rho-kinase inhibitor, after subarachnoid hemorrhage.

M. Takayasu, M. Shibuya, Kazuo Yano, 2012, Journal of pharmacological sciences.

Vasodilator actions of HA1077 in vitro and in vivo putatively mediated by the inhibition of protein kinase

H. Hidaka, M. Shibuya, Y. Suzuki, 1989, British journal of pharmacology.

Mechanism of action of a novel antivasospasm drug, HA1077.

H. Hidaka, M. Takayasu, M. Shibuya, 1987, The Journal of pharmacology and experimental therapeutics.

Evidence of a direct cellular protective effect of Rho-kinase inhibitors on endothelin-induced cardiac myocyte hypertrophy.

H. Shimokawa, I. Ikegaki, K. Kawasaki, 2012, Biochemical and biophysical research communications.

Inhibition of neutrophil migration by a protein kinase inhibitor for the treatment of ischemic brain infarction.

T. Kobayashi, J. Yoshida, M. Shibuya, 1999, Japanese journal of pharmacology.

Thromboxane A2 synthetase inhibitor failed to ameliorate the arterial narrowing during the chronic phase of cerebral vasospasm.

M. Shibuya, Y. Suzuki, S. Satoh, 1997, Life sciences.

Effects of neuropeptide Y on canine cerebral circulation.

M. Takayasu, M. Shibuya, Y. Suzuki, 1988, European journal of pharmacology.

Effect of Fasudil HCl, a protein kinase inhibitor, on cerebral vasospasm.

M. Shibuya, T. Asano, Y. Sasaki, 2001, Acta neurochirurgica. Supplement.

Naftopidil, a novel alpha1-adrenoceptor antagonist, displays selective inhibition of canine prostatic pressure and high affinity binding to cloned human alpha1-adrenoceptors.

G. Tsujimoto, K. Shibata, G Tsujimoto, 1999, Japanese journal of pharmacology.

A Protein Kinase Inhibitor, Fasudil (AT‐877): A Novel Approach to Signal Transduction Therapy

Yasuharu Sasaki, Toshio Asano, Ichiro Ikegaki, 1998 .

The role of platelets in the development of cerebral vasospasm

A. Saito, M. Shibuya, Yoshio Suzuki, 1991, Brain Research Bulletin.

The Inhibitory Effect of Recombinant Human Soluble Thrombomodulin on Initiation and Extension of Coagulation

E. Sugimoto, T. Asano, M. Mohri, 1999, Thrombosis and Haemostasis.

Adaptive properties of the b-wave and the PIII in the perfused isolated carp retina.

T. Asano, 1977, The Japanese journal of physiology.

TEA prevents the decline of the duration of the action potential in hypoxic cardiac muscle.

Y. Kasuya, K. Shigenobu, T. Asano, 1985, Japanese journal of pharmacology.

Correspondence Between Neurological Deficit, Cerebral Infarct Size, and Rho-Kinase Activity in a Rat Cerebral Thrombosis Model

H. Kuriyama, Yuki Yoshino, M. Seto, 2009, Journal of Molecular Neuroscience.

Effects of hypoxia and metabolic inhibitors on the electrical and mechanical activities of isolated guinea pig papillary muscles.

Y. Kasuya, K. Shigenobu, T. Asano, 1981, Journal of pharmacobio-dynamics.

Prostacyclin Does Not Inhibit Rho-Kinase: An Implication for the Treatment of Pulmonary Hypertension

K. Kaibuchi, H. Shimokawa, T. Uwatoku, 2005, Journal of cardiovascular pharmacology.

HA1077, a novel calcium antagonistic antivasospasm drug, increases both cerebral blood flow and glucose metabolism in conscious rats.

K. Sako, Y. Yonemasu, T. Asano, 1991, European journal of pharmacology.

Fasudil protects cultured N1E-115 cells against lysophosphatidic acid-induced neurite retraction through inhibition of Rho-kinase

I. Ikegaki, K. Kawasaki, T. Asano, 2011, Brain Research Bulletin.

Effects of Neuropeptide Y and Calcitonin Gene-Related Peptide on Local Cerebral Blood Flow in Rat Striatum

M. Shibuya, T. Okada, I. Ikegaki, 1989, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

The effects of HA1077, a novel protein kinase inhibitor, on reductions of cerebral blood flow and glucose metabolism following acute and/or chronic bilateral carotid artery ligation in Wistar rats

K. Sako, Y. Yonemasu, T. Asano, 2004, Experimental Brain Research.

Effects of hypoxia and reoxygenation on tissue ATP level and electrical and mechanical function of isolated guinea pig ventricular muscles.

Y. Kasuya, K. Shigenobu, T. Asano, 1984, Journal of Pharmacobio-Dynamics.

Protein kinase activity in canine basilar arteries after subarachnoid hemorrhage.

H. Hidaka, M. Takayasu, M. Shibuya, 1988, Neurosurgery.

A New Model of Cerebral Microthrombosis in Rats and the Neuroprotective Effect of a Rho-Kinase Inhibitor

I. Ikegaki, Y. Toshima, T. Asano, 2000, Stroke.

Hemorheological abnormalities in experimental cerebral ischemia and effects of protein kinase inhibitor on blood fluidity.

I. Ikegaki, T. Asano, S. Satoh, 2000, Life sciences.