C. W. Sigel

发表

Use of 1-H nuclear magnetic resonance spectroscopy for sequence and configuration analysis of cyclic tetrapeptides. The structure of Tentoxin-1,2a--d.

W. L. Meyer, L. Kuyper, R. Jones, 1975, Journal of the American Chemical Society.

Reaction of biological thiols with the tumor inhibitor jatrophone. Inhibition of RNA polymerase.

J. Lillehaug, K. Kleppe, S. M. Kupchan, 1973, Biochimica et biophysica acta.

Bruceantin, a new potent antileukemic simaroubolide from Brucea antidysenterica.

S. M. Kupchan, C. W. Sigel, R. W. Britton, 1973, The Journal of organic chemistry.

The role of dietary nitrate and nitrite in the reductive deamination of sulfadiazine by the rat, guinea pig, and neonatal calf.

J. L. Woolley, C. W. Sigel, 1982, Life sciences.

High‐Performance Liquid Chromatographic Assay for the Simultaneous Measurement of Trimethoprim and Sulfamethoxazole in Plasma or Urine

J. L. Woolley, C. W. Sigel, D. Deangelis, 1990, Therapeutic drug monitoring.

Specific TLC determination of trimethoprim and sulfamethoxazole in plasma.

G. Hitchings, M. Grace, C. A. Nichol, 1974, Journal of pharmaceutical sciences.

Metabolism of a novel antitumor agent, crisnatol, by a human hepatoma cell line, Hep G2, and hepatic microsomes. Characterization of metabolites.

J. Shockcor, S. Chang, S. Chang, 1991, Biochemical pharmacology.

The structure of tentoxin

W. L. Meyer, G. E. Templeton, C. I. Grable, 1971 .

Preclinical biochemical pharmacology and toxicology of piritrexim, a lipophilic inhibitor of dihydrofolate reductase.

B. Everitt, M. Collier, N. Clendeninn, 1987, NCI monographs : a publication of the National Cancer Institute.

2,4-Diamino-5-benzylpyrimidines and analogs as antibacterial agents. 9. Lipophilic trimethoprim analogs as antigonococcal agents

B. Roth, D. Baccanari, M. Grace, 1988 .

Disposition, metabolism, and excretion of the anticancer agent crisnatol in the rat.

L. Taylor, J. L. Woolley, C. W. Sigel, 1991, Drug metabolism and disposition: the biological fate of chemicals.

II. Novel deaminated sulfadiazine metabolites in neonatal calf tissue, plasma, and urine following oral treatment of 14C-sulfadiazine.

J. L. Woolley, C. W. Sigel, C. Wels, 1980, Life sciences.

Specific TLC tissue residue determination of sulfadiazine following fluorescamine derivatization.

C. A. Nichol, J. L. Woolley, C. W. Sigel, 1975, Journal of pharmaceutical sciences.

Synthesis and antitumor activity of 2,4-diamino-6-(2,5-dimethoxybenzyl)-5-methylpyrido[2,3-d]pyrimidine.

S. Lee, C. A. Nichol, D. Duch, 1980, Journal of medicinal chemistry.

Lipophilic Inhibitors of Dihydrofolate Reductase

C. A. Nichol, D. Duch, C. W. Sigel, 1984 .

Lipid-soluble inhibitors of dihydrofolate reductase. III: Quantitative thin-layer and high-performance liquid chromatographic methods for measuring plasma concentrations of the antifolate, 2,4-diamino-6-(2,5-dimethoxybenzyl)-5-methylpyrido-[2,3-d]pyrimidine.

C. W. Sigel, R. G. Foss, 1982, Journal of pharmaceutical sciences.

SYNTHESIS AND ANTITUMOR ACTIVITY OF 2,4‐DIAMINO‐6‐(2,5‐DIMETHOXYBENZYL)‐5‐METHYLPYRIDO(2,3‐D)PYRIMIDINE

Shuliang Lee, C. A. Nichol, D. Duch, 1980 .

Structure and stereochemistry of jatrophone, a novel macrocyclic diterpenoid tumor inhibitor.

C. Gilmore, S. M. Kupchan, R. Bryan, 1976, Journal of the American Chemical Society.

2,4-Diamino-5-benzylpyrimidines and analogues as antibacterial agents. 5. 3',5'-Dimethoxy-4'-substituted-benzyl analogues of trimethoprim.

B. Roth, R. Ferone, S. Bushby, 1981, Journal of medicinal chemistry.

Tumor inhibitors. LXV. Bersenogenin, berscillogenin, and 3-epiberscillogenin, three new cytotoxic bufadienolides from Bersama abyssinica.

R. J. Hemingway, S. M. Kupchan, J. L. Moniot, 1971, The Journal of organic chemistry.

Jatrophone, a novel macrocyclic diterpenoid tumor inhibitor from Jatropha gossypiifolia

S. M. Kupchan, R. Haltiwanger, R. Bryan, 1970 .

Terpenoids.Cis-trans- andtrans-cis- Nepetalactones

R. Bates, C. W. Sigel, 1963, Experientia.

Tumor inhibitors—XXXIII

R. J. Hemingway, S. M. Kupchan, J. R. Knox, 1969 .

Baquiloprim, a new antifolate antibacterial: in vitro activity and pharmacokinetic properties in cattle.

R. Ferone, H. R. Wilson, C. W. Sigel, 1993, Research in veterinary science.

Tumor inhibitors. XXXVI. Eupatin and eupatoretin, two cytotoxic flavonols from Eupatorium semiserratum

S. M. Kupchan, J. R. Knox, C. W. Sigel, 1969 .

Disposition and Metabolism of Trimethoprim, Tetroxoprim, Sulfamethoxazole, and Sulfadiazine

C. W. Sigel, 1983 .

Datiscoside, a novel antileukemic cucurbitacin glycoside from Datisca glomerata.

S. M. Kupchan, R. Restivo, R. Bryan, 1972, Journal of the American Chemical Society.

The isolation and structural elucidation of bruceantin and bruceantinol, new potent antileukemic quassinoids from Brucea antidysenterica.

S. M. Kupchan, C. W. Sigel, R. W. Britton, 1975, The Journal of organic chemistry.

A new fluorescence assay of trimethoprim and metabolites using quantitative thin-layer chromatography.

M. Grace, C. W. Sigel, 1973, Journal of chromatography.

Lipid-soluble inhibitors of dihydrofolate reductase. I. Kinetics, tissue distribution, and extent of metabolism of pyrimethamine, metoprine, and etoprine in the rat, dog, and man.

W. Brenckman, R. Deangelis, C. A. Nichol, 1978, Drug metabolism and disposition: the biological fate of chemicals.

Pharmacokinetics of trimethoprim and sulfadiazine in the dog: urine concentrations after oral administration.

S. Bushby, J. L. Woolley, C. W. Sigel, 1981, American journal of veterinary research.

Diterpenoid total synthesis, an A→B→C approach. IV. Total synthesis of methyl -dehydroabietate

W. L. Meyer, C. W. Sigel, 1967 .

Datiscacin, a novel cytotoxic cucurbitacin 20-acetate from Datisca glomerata.

S. M. Kupchan, C. W. Sigel, G. Tsou, 1973, The Journal of organic chemistry.

Competitive protein binding assay for piritrexim.

J L Woolley, C W Sigel, J L Ringstad, 1989, Journal of pharmaceutical sciences.

Solvent Effects on the Precision of Sample Application in Quantitative Thin-Layer Chromatography

R. Deangelis, C. W. Sigel, M. Robinson, 1980 .

Development of pharmacokinetic models for sulfonamides in food animals: metabolic depletion profile of sulfadiazine in the calf.

J. L. Woolley, C. W. Sigel, 1982, American Journal of Veterinary Research.

USE OF (1)H NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY FOR SEQUENCE AND CONFIGURATION ANALYSIS OF CYCLIC TETRAPEPTIDES. THE STRUCTURE OF TENTOXIN

W. L. Meyer, L. Kuyper, G. E. Templeton, 1975 .

Metabolism of trimethoprim in man and measurement of a new metabolite: a new fluorescence assay.

M. Grace, C. A. Nichol, C. W. Sigel, 1973, The Journal of infectious diseases.

Experimental induction of Proteus mirabilis cystitis in the pony and evaluation of therapy with trimethoprim-sulfadiazine.

T. Divers, O. Murch, C. W. Sigel, 1981, American journal of veterinary research.

Serum concentrations of trimethoprim and sulfadiazine following oral paste administration to the horse.

T. Divers, O. Murch, C. W. Sigel, 1981, American journal of veterinary research.

Lipid-soluble diaminopyrimidine inhibitors of dihydrofolate reductase.

C. A. Nichol, J. L. Woolley, C. W. Sigel, 1977, Cancer treatment reports.

The Application of Cross-Scanning to Conventional Thin-Layer Chromatography

R. Welch, R. Deangelis, C. W. Sigel, 1980 .

Metabolism and disposition by the rat of 35S-sulfadiazine alone and in the presence of trimethoprim.

J. L. Woolley, C. W. Sigel, 1979, Drug metabolism and disposition: the biological fate of chemicals.