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M. Fukagawa, K. Takeda, I. Imazeki, 2006, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

Klotho is associated with VEGF receptor-2 and the transient receptor potential canonical-1 Ca2+ channel to maintain endothelial integrity

M. Shibuya, Y. Mori, H. Matsubara, 2010, Proceedings of the National Academy of Sciences.

Effects of atorvastatin on oxidized low-density lipoprotein, low-density lipoprotein subfraction distribution, and remnant lipoprotein in patients with mixed hyperlipoproteinemia.

A. Azuma, K. Takeda, M. Nakagawa, 2002, The American journal of cardiology.

Retardation of the development of hypertension in DOCA-salt rats by renal denervation.

H. Ijichi, H. Takahashi, M. Yoshimura, 1984, Japanese circulation journal.

Reduction of insulin resistance attenuates the development of hypertension in sucrose-fed SHR.

H. Itoh, J. Moriguchi, M. Kiyama, 1997, Life sciences.

Blockade of angiotensin II receptors inhibits the increase in blood pressure induced by insulin.

H. Itoh, J. Moriguchi, M. Kiyama, 1998, Journal of cardiovascular pharmacology.

Sympathetic activation and contribution of genetic factors in hypertension with neurovascular compression of the rostral ventrolateral medulla.

H. Itoh, R. Fukuyama, S. Fushiki, 1999, Journal of hypertension.

Hypotensive responses to centrally administered taurine in DOCA-salt hypertensive and spontaneously hypertensive rats.

H. Ijichi, H. Takahashi, M. Yoshimura, 1986, Japanese circulation journal.

Enhanced renal sympathetic nerve activity in response to salt loading in rats.

H. Ijichi, H. Takahashi, M. Yoshimura, 1986, Japanese circulation journal.

HMG-CoA reductase inhibition improves anti-aging klotho protein expression and arteriosclerosis in rats with chronic inhibition of nitric oxide synthesis.

H. Matsubara, T. Tatsumi, H. Narumiya, 2008, International journal of cardiology.

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H. Itoh, K. Takeda, T. Nakata, 1994, American journal of hypertension.

Pancreatic hormones in streptozotocin-diabetic rats

T. Tomita, J. Kimmel, R. Buñag, 1986, International journal of pancreatology : official journal of the International Association of Pancreatology.

Neurovascular compression of the rostral ventrolateral medulla related to essential hypertension.

H. Itoh, O. Kizu, K. Takeda, 1997, Hypertension.

Pulsatile compression of the rostral ventrolateral medulla in hypertension.

H. Itoh, K. Takeda, T. Maeda, 1997, Hypertension.

Effects of angiotensin II type 1 receptor antagonist on pressor responses to pulsatile compression of the rostral ventrolateral medulla in rats.

K. Takeda, S. Morimoto, M. Nakagawa, 2004, Hypertension research : official journal of the Japanese Society of Hypertension.

Streptozotocin Diabetic Rats Are Hypertensive Despite Reduced Hypothalamic Responsiveness

T. Tomita, S. Sasaki, 1982, Hypertension.

The effects of temocapril, a new angiotensin converting enzyme inhibitor, on the quality of life in hypertensive patients

T. Ogihara, R. Morishita, J. Higaki, 1992 .

Chronic angiotensin blockade with candesartan cilexetil in DOCA/salt hypertensive rats reduces cardiac hypertrophy and coronary resistance without affecting blood pressure.

H. Itoh, K. Takeda, T. Nakata, 1997, Hypertension research : official journal of the Japanese Society of Hypertension.

Acute effects of captopril on the baroreflex of normotensive and spontaneously hypertensive rats.

Y. Nakamura, M. Yoshimura, H. Ashizawa, 1986, Japanese heart journal.

The significance of duration of salt loading on cardiovascular response and urinary excretion of catecholamine in rats.

H. Ijichi, H. Takahashi, M. Yoshimura, 1986, Endocrinologia japonica.

Pressor response to compression of the ventrolateral medulla mediated by glutamate receptors.

H. Itoh, K. Takeda, K. Nakamura, 1999, Hypertension.

[Case of non-Hodgkin lymphoma with acute renal failure successfully treated with chemotherapy].

T. Kusaba, H. Narumiya, T. Hatta, 2004, Nihon Jinzo Gakkai shi.

Calcium suppresses central angiotensin II pressor response less in SHR.

H. Itoh, K. Takeda, M. Tanaka, 1992, Clinical and experimental hypertension. Part A, Theory and practice.

Enhanced norepinephrine release in hypothalamus from locus coeruleus in SHR.

H. Itoh, K. Takeda, M. Tanaka, 1991, Japanese heart journal.

Peripheral origin of plasma dopamine.

H. Takahashi, S. Sasaki, A. Inoue, 1985, Japanese circulation journal.

Centrally-induced vasopressor responses to ouabain are augmented in spontaneously hypertensive rats.

H. Ijichi, H. Takahashi, M. Yoshimura, 1983, Clinical and experimental hypertension. Part A, Theory and practice.

Paraventricular nucleus lesions attenuate the development of hypertension in DOCA/salt-treated rats.

H. Itho, K. Takeda, T. Nakata, 1989, American journal of hypertension.

Effective treatment of acute theophylline intoxication with both direct hemoperfusion and hemodialysis

H. Matsubara, M. Okigaki, T. Kusaba, 2005 .

Sympathetic inhibition and attenuation of spontaneous hypertension by PVN lesions in rats

H. Itoh, K. Takeda, T. Nakata, 1991, Brain Research.

Renal denervation inhibits hypothalamo-sympathetic nerve system in normotensive and hypertensive rats.

H. Ijichi, H. Takahashi, M. Yoshimura, 1985, Japanese circulation journal.

Sympathetic and pressor hyperresponsiveness to intracisternal injections of hypertonic NaCl in DOCA hypertensive rats.

H. Ijichi, H. Takahashi, M. Yoshimura, 1981, Japanese circulation journal.

Comparative effects of candesartan and enalapril on augmented vasoconstrictive responses to endothelin-1 in coronary vessels of spontaneously hypertensive rats.

J. Moriguchi, T. Hatta, K. Takeda, 2002, American journal of hypertension.

Modulation of endothelin-1 coronary vasoconstriction in spontaneously hypertensive rats by the nitric oxide system.

H. Itoh, J. Moriguchi, M. Kiyama, 2000, American journal of hypertension.

PULSATILE COMPRESSION OF THE ROSTRAL VENTROLATERAL MEDULLA AS A CAUSE OF HYPERTENSION

H. Itoh, K. Takeda, T. Nakata, 1997 .

Effect of L-Arginine on Endothelium-Dependent Coronary Vasodilatory Reserve in Spontaneously Hypertensive Rats

T. Hatta, K. Takeda, T. Nakata, 2000 .

ROLE OF NITRIC OXIDE IN IMPAIRED CORONARY CIRCULATION AND IMPROVEMENT BY ANGIOTENSIN II RECEPTOR ANTAGONIST IN SPONTANEOUSLY HYPERTENSIVE RATS

H. Itoh, K. Takeda, K. Nakamura, 1995, Clinical and experimental pharmacology & physiology. Supplement.

Contrasting effects of angiotensin type 1 and 2 receptors on nitric oxide release under pressure.

R. Fukuyama, S. Fushiki, T. Hatta, 2002, Hypertension research : official journal of the Japanese Society of Hypertension.

Sarcoid granulomatous interstitial nephritis and sarcoid abdominal aortic aneurysms.

K. Kanda, H. Yaku, M. Okigaki, 2005, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

Central effect of captopril on baroreflex.

H. Ijichi, Y. Nakamura, K. Takeda, 1987, Clinical and experimental hypertension. Part A, Theory and practice.

[Inhibitory effects of dopamine biosynthesis on the development of spontaneous hypertension in rats].

Y. Nakamura, H. Takahashi, M. Yoshimura, 1986, Nihon Jinzo Gakkai shi.

Centrally-induced vasopressor responses to sodium-potassium adenosine triphosphatase inhibitor, ouabain, may be mediated via angiotensin II in the anteroventral third ventricle in the brain.

H. Ijichi, H. Takahashi, M. Yoshimura, 1984, Japanese circulation journal.

Clonidine improves central attenuation of the baroreflex in spontaneously hypertensive rats.

H. Itoh, K. Takeda, T. Nakata, 1993, Japanese heart journal.

Attenuated cardiovascular and sympathetic nerve responses to aortic nerve stimulation in DOCA-salt hypertensive rats.

Y. Nakamura, K. Takeda, M. Nakagawa, 1988, Journal of hypertension.

ROLE OF BAROREFLEX AND CENTRAL α2‐ADRENERGIC RECEPTOR SYSTEMS IN THE DIURNAL VARIATION OF BLOOD PRESSURE AND HEART RATE IN NORMOTENSIVE AND HYPERTENSIVE RATS

H. Itoh, Kazue Nakamura, K. Takeda, 1995, Clinical and experimental pharmacology & physiology. Supplement.

Association of Pressure Induced Hypertension with Specific Area of Ventrolateral Surface of Medulla Oblongata and Catecholamine Neurons

K. Kurokawa, H. Yamada, S. Morimoto, 2001 .

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Nitric oxide is an excitatory modulator in the rostral ventrolateral medulla in rats.

H. Itoh, Kazue Nakamura, S. Fushiki, 2000, American journal of hypertension.

Pressor response to pulsatile compression of the rostral ventrolateral medulla mediated by nitric oxide and c‐fos expression

H. Itoh, K. Takeda, T. Nakata, 2000, British journal of pharmacology.

EFFECTS OF GAMMA‐LINOLENIC AND EICOSAPENTAENOIC ACIDS ON BLOOD PRESSURE IN SHR

H. Itoh, K. Takeda, K. Nakamura, 1995, Clinical and experimental pharmacology & physiology. Supplement.

Central attenuation of baroreflex by angiotensin II in normotensive and spontaneously hypertensive rats.

Y. Nakamura, K. Takeda, T. Nakata, 1988, American journal of hypertension.

Pressor Responses to Intracisternal Injection of Hypertonic NaCl in Rats

H. Ijichi, H. Takahashi, M. Yoshimura, 1984, Journal of cardiovascular pharmacology.

Central baroreflex regulation by the renal nerves in anesthetized rats.

Y. Nakamura, H. Itoh, K. Takeda, 1989, Japanese circulation journal.

Young borderline hypertensives are hyperreactive to mental arithmetic stress: spectral analysis of R-R intervals.

H. Itoh, H Itoh, K. Takeda, 1995, Journal of the autonomic nervous system.

Insulin reverses hypertension and hypothalamic depression in streptozotocin diabetic rats.

R. Buñag, S. Sasaki, 1983, Hypertension.

Hypotension and hypothalamic depression produced by intracerebroventricular injections of GABA in spontaneously hypertensive rats.

H. Ijichi, Y. Nakamura, M. Yoshimura, 1986, Japanese circulation journal.

The role of the hypothalamic nitric oxide in the pressor responses elicited by acute environmental stress in awake rats.

H. Itoh, J. Moriguchi, T. Hatta, 2002, Life sciences.

Centrally induced vasopressor and sympathetic nerve responses to carbachol in rats.

H. Ijichi, H. Takahashi, M. Yoshimura, 1984, Japanese circulation journal.

Sustained-release diltiazem overdose

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Antihypertensive effect of taurine on salt-induced hypertension.

H. Itoh, M. Nakagawa, K. Takeda, 1994, Advances in experimental medicine and biology.

Unique association of pheochromocytoma with contralateral nonfunctioning adrenal cortical adenoma.

H. Itoh, J. Moriguchi, K. Takeda, 1998, American journal of hypertension.

Effects of angiotensin I converting enzyme (ACE) related substances upon the vascular prostacyclin generation.

Y. Nakamura, M. Nakagawa, H. Takamatsu, 1987, Agents and actions. Supplements.

KCl inhibits hypothalamic activity to attenuate hypertension in DOCA-salt rats.

H. Ijichi, H. Takahashi, M. Yoshimura, 1984, Japanese circulation journal.

Effects of pravastatin on exercise electrocardiography test performance and cardiovascular mortality and morbidity in patients with hypercholesterolemia: Lipid Intervention Study in Kyoto.

A. Azuma, K. Takeda, J. Asayama, 2002, Circulation journal : official journal of the Japanese Circulation Society.

Crossover trial of simvastatin versus pravastatin in patients with primary hypercholesterolemia.

H. Itoh, K. Kuriyama, K. Takeda, 1997, Journal of cardiovascular pharmacology.

HMG-CoA reductase inhibitors up-regulate anti-aging klotho mRNA via RhoA inactivation in IMCD3 cells.

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Reduction of white coat effect by cilnidipine in essential hypertension.

H. Itoh, J. Moriguchi, K. Takeda, 2001, American journal of hypertension.

Decreases in blood pressure and sympathetic nerve activity by microvascular decompression of the rostral ventrolateral medulla in essential hypertension.

K. Takeda, M. Saito, S. Morimoto, 1999, Stroke.

Centrally induced vasodepressor and sympathetic nerve responses to taurine.

H. Ijichi, H. Takahashi, M. Yoshimura, 1985, Japanese circulation journal.

Central Attenuation of Aortic Baroreceptor Reflex in Prehypertensive DOCA‐Salt‐Loaded Rats

K. Takeda, S. Sasaki, J. Hayashi, 1988, Hypertension.

Chronic sucrose ingestion induces mild hypertension and tachycardia in rats.

T. Tomita, R. Buñag, S. Sasaki, 1983, Hypertension.

Effects of Angiotensin I Converting Enzyme (ACE)-Related Substances on Prostacyclin Generation and ACE Activity of Human Vascular Endothelial Cells and Rat Aortic Rings

H. Ijichi, M. Nakagawa, H. Takamatsu, 1987, Journal of cardiovascular pharmacology.

Alteration of Response to Neuropeptide Y in the Nucleus Tractus Solitarius of Spontaneously Hypertensive Rats

H. Itoh, K. Takeda, T. Nakata, 1994, Hypertension.

Altered noradrenergic projection to hypothalamus via baroreflex in spontaneously hypertensive rats.

Y. Nakamura, H. Itoh, K. Takeda, 1991, American Journal of Hypertension.

GABAB-ergic stimulation in hypothalamic pressor area induces larger sympathetic and cardiovascular depression in spontaneously hypertensive rats.

H. Itoh, K. Takeda, K. Nakamura, 1996, American journal of hypertension.

Central GABA-ergic stimulation attenuates hypertension and hypothalamic hyperactivity in spontaneously hypertensive rats.

H. Takahashi, M. Yoshimura, S. Kambara, 1986, Journal of hypertension. Supplement : official journal of the International Society of Hypertension.

Hypothalamic pressor responses and salt-induced hypertension in Dahl rats.

R. Buñag, S. Sasaki, J. Butterfield, 1983, Hypertension.

Central attenuation of baroreflex precedes the development of hypertension in DOCA-salt-treated rats.

Y. Nakamura, K. Takeda, T. Nakata, 1988, American journal of hypertension.

Effects of salt and DOCA on hypothalamic and baroreflex control of blood pressure.

Y. Nakamura, K. Takeda, T. Nakata, 1988, Clinical and experimental hypertension. Part A, Theory and practice.

CENTRALLY-INDUCED VASOPRESSOR RESPONSES

H. Ijichi, Hakuo Takahashi, M. Yoshimura, 1984 .

Augmented central cholinergic mechanisms in spontaneously hypertensive rats. Involvement of deranged noradrenergic mechanisms in the brain.

H. Ijichi, H. Takahashi, M. Yoshimura, 1984, Japanese heart journal.

The role of prostaglandins in the regulation of blood pressure with special reference to vascular reactivity.

H. Ijichi, H. Takahashi, M. Yoshimura, 1984, Japanese circulation journal.

Role of the central nervous system in the development of hypertension produced by chronic nitric oxide blockade in rats.

H. Itoh, T. Hatta, K. Takeda, 2001, Hypertension research : official journal of the Japanese Society of Hypertension.

Comparative studies of angiotensin converting enzyme inhibitors with and without the SH-radical.

M. Nakagawa, K. Takeda, H. Tsuji, 1991, American Journal of Hypertension.

Inhibitory guanine nucleotide regulatory protein alpha-subunits in brain of spontaneously hypertensive rats.

K. Kuriyama, M. Nakagawa, S. Sasaki, 1996, Life sciences.

Retardation of the development of hypertension in DOCA salt rats by taurine supplement.

H. Takahashi, M. Yoshimura, K. Takeda, 1988, Cardiovascular research.

Central γ-aminobutyric acid stimulation attenuates pressor responses to intracisternal injection of hypertonic NaCl in rats

M. Nakagawa, S. Sasaki, Y. Yoneda, 1993 .

Chronic Central GABAergic Stimulation Attenuates Hypothalamic Hyperactivity and Development of Spontaneous Hypertension in Rats

K. Takeda, T. Nakata, M. Nakagawa, 1990, Journal of cardiovascular pharmacology.

The role of hypothalamo-sympathetic nerve system to maintain high blood pressure in DOCA hypertensive rats.

H. Ijichi, M. Yoshimura, R. Buñag, 1980, Japanese circulation journal.

Augmentation of Pulse Wave Velocity Precedes Vascular Structural Changes of the Aorta in Rats Treated with N ω-Nitro-L-Arginine Methyl Ester

M. Okigaki, T. Kusaba, H. Narumiya, 2005, Hypertension Research.

Effect of manidipine, a novel calcium channel blocker, on quality of life in hypertensive patients.

T. Ogihara, H. Mikami, M. Nagano, 1992, Blood pressure. Supplement.

Effect of sodium loading and depletion on vascular reactivity and prostacyclin generation.

H. Ijichi, M. Yoshimura, Y. Kajita, 1980, Japanese circulation journal.

FUNCTIONAL ALTERATION OF THE GABAB RECEPTOR IN THE BRAIN OF SPONTANEOUSLY HYPERTENSIVE RATS

K. Kuriyama, K. Takeda, M. Nakagawa, 1995, Clinical and experimental pharmacology & physiology. Supplement.

HYPOTHALAMIC AND MEDULLARY GABAA AND GABAb‐ERGIC SYSTEMS DIFFERENTLY REGULATE SYMPATHETIC AND CARDIOVASCULAR SYSTEMS

H. Itoh, K. Takeda, K. Nakamura, 1995, Clinical and experimental pharmacology & physiology. Supplement.