N. Inatomi

发表

Role of endogenous basic fibroblast growth factor in the healing of gastric ulcers in rats.

S. Szabó, J. Folkman, H. Satoh, 1997, Japanese journal of pharmacology.

High-Throughput Screening of Potassium-Competitive Acid Blockers

A. Hasuoka, M. Kajino, N. Inatomi, 2012, Journal of biomolecular screening.

Characterization of a Novel Potassium-Competitive Acid Blocker of the Gastric H,K-ATPase, 1-[5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl]-N-methylmethanamine Monofumarate (TAK-438)

G. Sachs, O. Vagin, E. Tokhtaeva, 2011, Journal of Pharmacology and Experimental Therapeutics.

Intracellular cyclic adenosine 3', 5'-monophosphate and relaxing effects of isoprenaline and papaverine on smooth muscle of intestine.

M. Uchida, K. Takagi, I. Takayanagi, 1972, Japanese journal of pharmacology.

EM574, an erythromycin derivative, is a motilin receptor agonist in the rabbit.

S. Ōmura, A. Shino, M. Sekiguchi, 1997, European journal of pharmacology.

Isolation and identification of EG-VEGF/prokineticins as cognate ligands for two orphan G-protein-coupled receptors.

S. Hinuma, Y. Shintani, H. Onda, 2002, Biochemical and biophysical research communications.

Indomethacin‐induced changes in canine gastric mucosal haemodynamics and haemoglobin oxygenation, and the effects of topical anti‐ulcer agents

T. Kamada, H. Satoh, N. Sato, 1986 .

Effects of TAK-637, a novel neurokinin-1 receptor antagonist, on colonic function in vivo.

H. Natsugari, Y. Ikeura, N. Inatomi, 2001, The Journal of pharmacology and experimental therapeutics.

Effects of anti-ulcer agents on thermal-cortisone-induced ulcers in rats.

Y. Ishihara, S. Okabe, N. Inatomi, 1979, Japanese journal of pharmacology.

Spizofurone (AG-629) increases gastric mucosal blood flow in dogs: a possible mechanism of its anti-ulcer effect.

H. Satoh, Y. Maki, N. Inatomi, 1985, European journal of pharmacology.

Mode of Action of Macrolides with Motilin Agonistic Activity—Motilides

S. Ōmura, Z. Itoh, N. Inatomi, 2003 .

EM574, an erythromycin derivative, improves delayed gastric emptying of semi-solid meals in conscious dogs.

S. Ōmura, S. Marui, Z. Itoh, 2000, European journal of pharmacology.

An erythromycin derivative, EM-523, induces motilin-like gastrointestinal motility in dogs.

S. Ōmura, H. Satoh, Y. Maki, 1989, The Journal of pharmacology and experimental therapeutics.

Motilides, macrolides with gastrointestinal motor stimulating activity. I. O-substituted and tertiary N-substituted derivatives of 8,9-anhydroerythromycin A 6,9-hemiacetal.

S. Ōmura, H. Toyoda, T. Sunazuka, 1989, Chemical & pharmaceutical bulletin.

Motilides, macrolides with gastrointestinal motor stimulating activity. II. Quaternary N-substituted derivatives of 8,9-anhydroerythromycin A 6,9-hemiacetal and 9,9-dihydroerythromycin A 6,9-epoxide.

S. Ōmura, H. Toyoda, T. Sunazuka, 1989, Chemical & pharmaceutical bulletin.

Bioactive metabolites of EM574 and EM523, erythromycin derivatives having strong gastrointestinal motor stimulating activity.

S. Ōmura, S. Harada, Y. Maeshiba, 1996, The Journal of antibiotics.

Antisecretory and antiulcer activities of a novel proton pump inhibitor AG-1749 in dogs and rats.

H. Satoh, Y. Maki, N. Nakamura, 1989, The Journal of pharmacology and experimental therapeutics.

Effects of the enantiomers of lansoprazole (AG-1749) on (H+ + K+)-ATPase activity in canine gastric microsomes and acid formation in isolated canine parietal cells.

H. Satoh, N. Inatomi, H. Nagaya, 1991, Biochemical pharmacology.

1-[5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl]-N-methylmethanamine Monofumarate (TAK-438), a Novel and Potent Potassium-Competitive Acid Blocker for the Treatment of Acid-Related Diseases

M. Kajino, Y. Tsukimi, N. Inatomi, 2010, Journal of Pharmacology and Experimental Therapeutics.

Discovery of a novel pyrrole derivative 1-[5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl]-N-methylmethanamine fumarate (TAK-438) as a potassium-competitive acid blocker (P-CAB).

Terufumi Takagi, Terufumi Takagi, Teruki Hamada, 2012, Journal of medicinal chemistry.

Antiphosphodiesterase activity and nonspecific smooth muscle relaxation tested on intestinal smooth muscles.

K. Takagi, I. Takayanagi, N. Inatomi, 1975, Japanese journal of pharmacology.

Intracellular cyclic AMP level and intestinal smooth muscle relaxation.

M. Uchida, K. Takagi, I. Takayanagi, 1974, European journal of pharmacology.

Anti-oxytocin actions of papaverine, aspaminol and isoprenaline on the rat uterus and intracellular cyclin adenosine 3,5-monophosphate level.

K. Takagi, T. Uruno, I. Takayanagi, 1973, Japanese journal of pharmacology.

Discovery, synthesis, and structure-activity relations of 3,4-dihydro-1H-spiro(naphthalene-2,2'-piperidin)-1-ones as potassium-competitive acid blockers.

Terufumi Takagi, T. Imaeda, F. Itoh, 2017, Bioorganic & medicinal chemistry.

Discovery, synthesis, and biological evaluation of novel pyrrole derivatives as highly selective potassium-competitive acid blockers.

Terufumi Takagi, A. Hasuoka, M. Kajino, 2012, Bioorganic & medicinal chemistry.

Differences in the antisecretory actions of the proton pump inhibitor AG-1749 (lansoprazole) and the histamine H2-receptor antagonist famotidine in rats and dogs.

H. Satoh, N. Inatomi, H. Nagaya, 1991, Japanese journal of pharmacology.

Macrolides with gastrointestinal motor stimulating activity.

S. Ōmura, H. Toyoda, T. Sunazuka, 1987, Journal of medicinal chemistry.

Characteristics of the Novel Potassium-Competitive Acid Blocker Vonoprazan Fumarate (TAK-438)

Y. Sakurai, Y. Tagawa, Masatoshi Karashima, 2016, Advances in Therapy.

Microbial conversion of EM574 and EM523, gastrointestinal motor stimulating agents.

S. Ōmura, S. Tanida, S. Harada, 1996, The Journal of antibiotics.

Comparison of the motor-stimulating action of EM523, an erythromycin derivative, and prostaglandin F2 alpha in conscious dogs.

S. Ōmura, H. Satoh, Z. Itoh, 1993, Japanese journal of pharmacology.

[Motilide, motilin-like macrolides].

S. Ōmura, Z. Itoh, N. Inatomi, 1993, Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme.

Effects of a proton pump inhibitor, AG-1749 (lansoprazole), on reflux esophagitis and experimental ulcers in rats.

H. Satoh, A. Shino, N. Inatomi, 1991, Japanese journal of pharmacology.

Effects of tachykinin NK1 receptor antagonists on the viscerosensory response caused by colorectal distention in rabbits.

Y. Ikeura, N. Inatomi, S. Okano, 2002, The Journal of pharmacology and experimental therapeutics.

Novelty stress increases fecal pellet output in mongolian gerbils: effects of several drugs.

N. Inatomi, H. Nagaya, S. Okano, 2005, Journal of pharmacological sciences.

Effects of TAK-480, a novel tachykinin NK(2)-receptor antagonist, on visceral hypersensitivity in rabbits and ricinoleic acid-induced defecation in guinea pigs.

Takahiro Tanaka, A. Tanaka, M. Toyoda, 2012, Journal of pharmacological sciences.

Establishment and validation of a rabbit model for in vivo pharmacodynamic screening of tachykinin NK2 antagonists.

Takahiro Tanaka, M. Yamaguchi, H. Kamiguchi, 2012, Journal of pharmacological sciences.

Potassium-competitive acid blockers: Advanced therapeutic option for acid-related diseases.

Y. Sakurai, N. Inatomi, Jun Matsukawa, 2016, Pharmacology & therapeutics.

Identification of a novel fluoropyrrole derivative as a potassium-competitive acid blocker with long duration of action.

Teruki Hamada, T. Imaeda, F. Itoh, 2017, Bioorganic & medicinal chemistry.

A Study Comparing the Antisecretory Effect of TAK-438, a Novel Potassium-Competitive Acid Blocker, with Lansoprazole in Animals

M. Kajino, T. Takeuchi, N. Inatomi, 2011, Journal of Pharmacology and Experimental Therapeutics.

EM-523, an erythromycin derivative, and motilin show similar contractile activity in isolated rabbit intestine.

S. Ōmura, H. Satoh, S. Marui, 1990, The Journal of pharmacology and experimental therapeutics.

A comparative study on the modes of action of TAK-438, a novel potassium-competitive acid blocker, and lansoprazole in primary cultured rabbit gastric glands.

M. Kajino, N. Inatomi, Jun Matsukawa, 2011, Biochemical pharmacology.

The effects of varying acidity on Helicobacter pylori growth and the bactericidal efficacy of ampicillin

G. Sachs, D. Scott, E. Marcus, 2012, Alimentary pharmacology & therapeutics.

Radiographic Localization Study of a Novel Potassium-Competitive Acid Blocker, Vonoprazan, in the Rat Gastric Mucosa

Y. Tagawa, N. Inatomi, Akifumi Kogame, 2016, Digestive Diseases and Sciences.

Exploration of pyrrole derivatives to find an effective potassium-competitive acid blocker with moderately long-lasting suppression of gastric acid secretion.

Ikuo Fujimori, F. Itoh, Y. Fujioka, 2017, Bioorganic & medicinal chemistry.

Spizofurone, a new anti-ulcer agent, increases alkaline secretion in isolated bullfrog duodenal mucosa.

H. Satoh, Y. Maki, N. Inatomi, 1986, European journal of pharmacology.

Gastric mucosal protection by spizofurone.

H. Satoh, Y. Maki, N. Inatomi, 1985, European journal of pharmacology.

monofumarate (TAK-438), A Novel and Potent Potassium-Competitive Acid Blocker for the Treatment of Acid-Related Diseases. Authors

M. Kajino, Y. Tsukimi, N. Inatomi, 2010 .

Effect of prostaglandins on mucosal blood flow and aspirin-induced damage in the canine stomach.

Y. Maki, N. Inatomi, 1983, Japanese journal of pharmacology.

[Effects of lansoprazole on indomethacin-induced gastric bleeding and mucosal lesions in rats].

H. Satoh, S. Asano, I. Murakami, 1996, Nihon yakurigaku zasshi. Folia pharmacologica Japonica.

[Effects of intravenous lansoprazole on acute gastric mucosal lesions and acid secretion].

H. Satoh, S. Asano, I. Murakami, 1996, Nihon yakurigaku zasshi. Folia pharmacologica Japonica.

Synthetic studies of five-membered heteroaromatic derivatives as potassium-competitive acid blockers (P-CABs).

Terufumi Takagi, A. Hasuoka, F. Itoh, 2015, Bioorganic & medicinal chemistry letters.

Vagus-dependent and vagus-independent mechanisms of action of the erythromycin derivative EM574 and motilin in dogs.

S. Ōmura, S. Marui, Z. Itoh, 1996, Japanese journal of pharmacology.

Role of xanthine oxidase in ethanol-induced lipid peroxidation in rats.

C. Lieber, S. Kato, J. Alderman, 1990, Gastroenterology.