Wenzhong Yan

发表

Dual-acting antitumor agents targeting the A2A adenosine receptor and histone deacetylases: Design and synthesis of 4-(furan-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-6-amine derivatives.

Hualiang Jiang, K. Wüthrich, Cheng-ying Xie, 2022, European journal of medicinal chemistry.

TSPA as a novel ATF6α translocation inducer efficiently ameliorates insulin sensitivity restoration and glucose homeostasis in db/db mice.

Xu Shen, J. Chen, Jinpei Zhou, 2018, Biochemical and biophysical research communications.

Cyclophilin A Associates with Enterovirus-71 Virus Capsid and Plays an Essential Role in Viral Infection as an Uncoating Regulator

Yuna Sun, Z. Rao, Lei Liu, 2014, PLoS pathogens.

Discovery of novel purine nucleoside derivatives as phosphodiesterase 2 (PDE2) inhibitors: Structure-based virtual screening, optimization and biological evaluation.

Hai-bin Luo, Jian Li, Yi-You Huang, 2018, Bioorganic & medicinal chemistry.

Long Residence Time at the Vasopressin V2 Receptor Translates into Superior Inhibitory Effects in Ex Vivo and In Vivo Models of Autosomal Dominant Polycystic Kidney Disease.

Ying Sun, Peng-Cheng Wang, Jianjun Cheng, 2022, Journal of medicinal chemistry.

Revisit ligand-receptor interaction at the human vasopressin V2 receptor: A kinetic perspective.

L. Peletier, D. Guo, Xudong Cao, 2020, European journal of pharmacology.

Discovery of Novel Small Molecule Anti-HCV Agents via the CypA Inhibitory Mechanism Using O-Acylation-Directed Lead Optimization

Hualiang Jiang, Jin Huang, Lei Liu, 2015, Molecules.

Synthesis of 3-substituted 1,5-aldehyde esters via an organocatalytic highly enantioselective conjugate addition of new carbonylmethyl 2-pyridinylsulfone to enals.

Hualiang Jiang, Fei Wang, Wei Wang, 2012, Chemical communications.

Discovery and optimization of 1,3,4-trisubstituted-pyrazolone derivatives as novel, potent, and nonsteroidal farnesoid X receptor (FXR) selective antagonists.

Ying Yu, Zhenting Gao, Wenzhong Yan, 2012, Journal of medicinal chemistry.

Identification, synthesis and pharmacological evaluation of novel anti-EV71 agents via cyclophilin A inhibition.

Hualiang Jiang, Jin Huang, Lei Liu, 2015, Bioorganic & medicinal chemistry letters.

2-Phenylcyclopropylmethylamine Derivatives as Dopamine D2 Receptor Partial Agonists: Design, Synthesis, and Biological Evaluation.

Jianjun Cheng, Ruiquan Liu, Wenzhong Yan, 2021, Journal of medicinal chemistry.

Design and synthesis of tri-substituted pyrimidine derivatives as bifunctional tumor immunotherapeutic agents targeting both A2A adenosine receptors and histone deacetylases

Jianjun Cheng, Ruiquan Liu, Jinfeng Zhang, 2023, Chinese Chemical Letters.

Structure-Based Design of Dual-Acting Compounds Targeting Adenosine A2A Receptor and Histone Deacetylase as Novel Tumor Immunotherapeutic Agents.

Hualiang Jiang, Guisheng Zhong, Suwen Zhao, 2021, Journal of medicinal chemistry.

Tumor Immunotherapy Using A2A Adenosine Receptor Antagonists

K. Wüthrich, Wenwen Duan, Jianjun Cheng, 2020, Pharmaceuticals.

Biased Ligands of G Protein-Coupled Receptors (GPCRs): Structure-Functional Selectivity Relationships (SFSRs) and Therapeutic Potential.

J. McCorvy, Jianjun Cheng, Wenzhong Yan, 2018, Journal of medicinal chemistry.

Optical-Controlled Kinetic Switch: Fine-Tuning of the Residence Time of an Antagonist Binding to the Vasopressin V2 Receptor in In Vitro, Ex Vivo, and In Vivo Models of ADPKD.

Jianjun Cheng, Wenzhong Yan, Xiaoke Gu, 2022, Journal of medicinal chemistry.

Design and Synthesis of Triazole-Containing HDAC Inhibitors That Induce Antitumor Effects and Immune Response.

Cheng-ying Xie, Wenwen Duan, Jianjun Cheng, 2023, Journal of medicinal chemistry.

Design and Synthesis of Bitopic 2-Phenylcyclopropylmethylamine (PCPMA) Derivatives as Selective Dopamine D3 Receptor Ligands.

Xi-Ping Huang, Jian Sun, Suwen Zhao, 2020, Journal of medicinal chemistry.