Isao Sakurada

发表

Discovery of novel aminobenzisoxazole derivatives as orally available factor IXa inhibitors.

T. Mizuno, K. Takeuchi, A. Hruza, 2017, Bioorganic & medicinal chemistry letters.

Development of a novel tricyclic class of potent and selective FIXa inhibitors.

J. Metzger, R. Berger, Hong Li, 2015, Bioorganic & medicinal chemistry letters.

Facile synthesis of bromo- and iodo-1,2,3-triazoles

Isao Sakurada, 2017 .

Structure-activity relationship study of novel NR2B-selective antagonists with arylamides to avoid reactive metabolites formation.

Kazunari Hattori, T. Honma, K. Ando, 2007, Bioorganic & medicinal chemistry letters.

Dichlorotin oxide-catalyzed new direct functionalization of olefins: synthesis of trans β-azidohydrins and 1,2-diols

M. Kanai, M. Shibasaki, Isao Sakurada, 2000 .

Direct Chlorohydrin and Acetoxy Alcohol Synthesis from Olefins Promoted by a Lewis Acid, Bis(trimethylsilyl) Peroxide and (CH3)3SiX

M. Shibasaki, R. Göttlich, Isao Sakurada, 2000 .

Discovery of novel and orally active NR2B-selective N-methyl-D-aspartate (NMDA) antagonists, pyridinol derivatives with reduced HERG binding affinity.

Kazunari Hattori, K. Ando, M. Kawai, 2007, Bioorganic & medicinal chemistry letters.

Discovery and preclinical characterization of 1-methyl-3-(4-methylpyridin-3-yl)-6-(pyridin-2-ylmethoxy)-1H-pyrazolo-[3,4-b]pyrazine (PF470): a highly potent, selective, and efficacious metabotropic glutamate receptor 5 (mGluR5) negative allosteric modulator.

J. Cianfrogna, A. Stepan, Daniel P. Walker, 2014, Journal of medicinal chemistry.

Development of a novel class of potent and selective FIXa inhibitors.

E. Sherer, K. Ellsworth, W. Geissler, 2015, Bioorganic & medicinal chemistry letters.

Discovery of (-)-6-[2-[4-(3-fluorophenyl)-4-hydroxy-1-piperidinyl]-1-hydroxyethyl]-3,4-dihydro-2(1H)-quinolinone--a potent NR2B-selective N-methyl D-aspartate (NMDA) antagonist for the treatment of pain.

Kazunari Hattori, Masaki Sudo, K. Ando, 2007, Bioorganic & medicinal chemistry letters.

Discovery and Characterization of (R)-6-Neopentyl-2-(pyridin-2-ylmethoxy)-6,7-dihydropyrimido[2,1-c][1,4]oxazin-4(9H)-one (PF-06462894), an Alkyne-Lacking Metabotropic Glutamate Receptor 5 Negative Allosteric Modulator Profiled in both Rat and Nonhuman Primates.

J. Cianfrogna, A. Stepan, Daniel P. Walker, 2017, Journal of medicinal chemistry.

Highly Potent , Selective , and E ffi cacious Metabotropic Glutamate Receptor 5 ( mGluR 5 ) Negative Allosteric Modulator

Ey, J. Cianfrogna, A. Stepan, 2014 .