Conrad Fischer

发表

Synthetic Modification within the "RPRL" Region of Apelin Peptides: Impact on Cardiovascular Activity and Stability to Neprilysin and Plasma Degradation.

J. Vederas, G. Oudit, C. Llorens-Cortes, 2017, Journal of medicinal chemistry.

Optimizing PEG-Extended Apelin Analogues as Cardioprotective Drug Leads: Importance of the KFRR Motif and Aromatic Head Group for Improved Physiological Activity.

J. Vederas, Weiqi Wang, G. Oudit, 2020, Journal of medicinal chemistry.

Metabolically stable apelin-analogues, incorporating cyclohexylalanine and homoarginine, as potent apelin receptor activators.

J. Vederas, G. Oudit, C. Llorens-Cortes, 2021, RSC medicinal chemistry.

A patent review of apelin receptor (APJR) modulators (2014-2019)

Conrad Fischer, 2020, Expert opinion on therapeutic patents.

Plasma kallikrein cleaves and inactivates apelin-17: Palmitoyl- and PEG-extended apelin-17 analogs as metabolically stable blood pressure-lowering agents.

J. Vederas, G. Oudit, C. Llorens-Cortes, 2019, European journal of medicinal chemistry.

The Metalloprotease Neprilysin Degrades and Inactivates Apelin Peptides

J. Vederas, G. Oudit, Wang Wang, 2016, Chembiochem : a European journal of chemical biology.

PLP-independent racemization: mechanistic and mutational studies of O-ureidoserine racemase (DcsC).

J. Vederas, Conrad Fischer, M. V. van Belkum, 2018, Organic & biomolecular chemistry.

Apelin directs endothelial cell differentiation and vascular repair following immune-mediated injury.

J. Vederas, A. Azad, Hao Zhang, 2019, The Journal of clinical investigation.

Isolation, expression and biochemical characterization of recombinant hyoscyamine-6β-hydroxylase from Brugmansia sanguinea - tuning the scopolamine production.

J. Vederas, Conrad Fischer, M. Kwon, 2018, MedChemComm.

N-Terminal Finger Stabilizes the S1 Pocket for the Reversible Feline Drug GC376 in the SARS-CoV-2 Mpro Dimer

J. Vederas, R. McKay, E. Arutyunova, 2021, Journal of Molecular Biology.

N-Terminal finger stabilizes the reversible feline drug GC376 in SARS-CoV-2 Mpro

J. Vederas, R. McKay, E. Arutyunova, 2021, bioRxiv.

2,2′-Dimethyl-4,4′-bipyridine

E. Weber, Wilhelm Seichter, Conrad Fischer, 2008, Acta crystallographica. Section E, Structure reports online.

Bridge-disubstituted calix[4]arenes obtained via a new preparative route. Synthesis and structural study

E. Weber, Wilhelm Seichter, Conrad Fischer, 2011 .

Unusual Behavior of a Calix[4]arene Featuring the Coexistence of Basic Cone and 1,2-Alternate Conformations in a Solvated Crystal

E. Weber, T. Gruber, Wilhelm Seichter, 2011 .

Calix[4]arenes featuring a direct lower rim attachment of dansyl groups. Synthesis, fluorescence properties and first report on crystal structures.

E. Weber, T. Gruber, Wilhelm Seichter, 2009, Organic & biomolecular chemistry.

Simple two step reaction towards a 2,7,14,21-tetraoxocalix[4]arene via bridge brominated intermediate

E. Weber, Wilhelm Seichter, Conrad Fischer, 2013 .

Bridge-substituted calix[4]arenes: syntheses, conformations and application.

E. Weber, T. Gruber, Wilhelm Seichter, 2011, Organic & biomolecular chemistry.

Influence of laterally attached alkyl groups on the conformational behaviour of a basic calix[4]arene: combined NMR, molecular mechanics and X-ray study

E. Weber, T. Gruber, Conrad Fischer, 2010 .

Conformational behaviour and first crystal structures of a calix[4]arene featuring a laterally positioned carboxylic acid function in unsolvated and solvent-complexed forms

E. Weber, T. Gruber, P. Bombicz, 2010 .

Bis-calix[4]arene-based podants using the bridge position as a constructive mode of subunit connection

E. Weber, Conrad Fischer, 2014, Journal of Inclusion Phenomena and Macrocyclic Chemistry.

Fluorescent chemosensors based on a new type of lower rim-dansylated and bridge-substituted calix[4]arenes

E. Weber, Wilhelm Seichter, Conrad Fischer, 2013 .

Easily accessible symmetrically and unsymmetrically bridge disubstituted tetrahydroxycalix[4]arenes in advantageous trans-cone conformation

E. Weber, F. Katzsch, Conrad Fischer, 2013 .

Fine-tuning of packing architecture: symmetrically bridge-disubstituted tetramethoxycalix[4]arenes

E. Weber, P. Bombicz, Wilhelm Seichter, 2013, Structural Chemistry.

Bridge-Disubstituted Calix[4]arenes in the Rare 1,2-Alternate Conformation: Control of the Inclusion Behavior Depending on the Bridge Substituents

E. Weber, P. Bombicz, F. Katzsch, 2012 .

Structural conditions required for the bridge lithiation and substitution of a basic calix[4]arene

E. Weber, Wilhelm Seichter, Conrad Fischer, 2011, Beilstein journal of organic chemistry.

Comparative X-ray structural study of laterally mono-ethyl substituted 5,11,17,23-tetra-tert-butyl-25,26,27,28-tetra-methoxycalix[4]arene and its non-substituted parent compound including guest free and solvated forms. Chemical straightening of guest channels

E. Weber, P. Bombicz, Wilhelm Seichter, 2011 .

Fine tuning of crystal architecture by intermolecular interactions: synthon engineering

E. Weber, T. Gruber, P. Bombicz, 2014 .

Upper rim site lipophilic calix[4]arenes as receptors for natural terpenes and functionally related solvent molecules: combined crystal structure and QMB sensor study

E. Weber, T. Gruber, P. Bombicz, 2011 .

5,11,17,23-Tetra-tert-butyl-25,26,27,28-tetramethoxycalix[4]arene tetrahydrofuran solvate

E. Weber, T. Gruber, Wilhelm Seichter, 2007 .

5,11,17,23-Tetra-tert-butyl-25,26,27,28-tetramethoxycalix[4]arene dichloromethane hemisolvate

Tobias Gruber, Wilhelm Seichter, Edwin Weber, 2008, Acta crystallographica. Section E, Structure reports online.

2-(4-Bromobenzyl)-5,11,17,23-tetra-tert-butyl-25,26,27,28-tetramethoxycalix[4]arene

Wilhelm Seichter, Edwin Weber, Conrad Fischer, 2009, Acta crystallographica. Section E, Structure reports online.

Improved SARS-CoV-2 Mpro inhibitors based on feline antiviral drug GC376: Structural enhancements, increased solubility, and micellar studies

J. Vederas, E. Arutyunova, Justin Shields, 2021, European Journal of Medicinal Chemistry.

Feline coronavirus drug inhibits the main protease of SARS-CoV-2 and blocks virus replication

D. Lorne Tyrrell, John C. Vederas, Ryan T. McKay, 2020, Nature Communications.

Catalytic mechanism and properties of pyridoxal 5'-phosphate independent racemases: how enzymes alter mismatched acidity and basicity.

J. Vederas, Conrad Fischer, Yeong-Chan Ahn, 2019, Natural product reports.

Author Correction: Feline coronavirus drug inhibits the main protease of SARS-CoV-2 and blocks virus replication

J. Vederas, R. McKay, E. Arutyunova, 2020, Nature Communications.

Peptidomimetic α-Acyloxymethylketone Warheads with Six-Membered Lactam P1 Glutamine Mimic: SARS-CoV-2 3CL Protease Inhibition, Coronavirus Antiviral Activity, and in Vitro Biological Stability

J. Vederas, E. Arutyunova, Justin Shields, 2021, Journal of medicinal chemistry.

Catalytic Plasticity of Germacrene A Oxidase Underlies Sesquiterpene Lactone Diversification1 [OPEN].

D. Ro, Trinh-Don Nguyen, Conrad Fischer, 2019, Plant physiology.

Apelin protects against abdominal aortic aneurysm and the therapeutic role of neutral endopeptidase resistant apelin analogs

Doran S. Mix, J. Vederas, J. Penninger, 2019, Proceedings of the National Academy of Sciences.

Crystallization of Feline Coronavirus Mpro With GC376 Reveals Mechanism of Inhibition

J. Vederas, E. Arutyunova, H. Young, 2022, Frontiers in Chemistry.

Crystal structures of benzil monoximes controlled through configurational isomerism, molecular substitution and external complexation

E. Weber, A. Schwarzer, Wilhelm Seichter, 2011 .

Catalytic Plasticity of Germacrene A Oxidase Underlies Sesquiterpene Lactone Diversification1[OPEN]

D. Ro, Trinh-Don Nguyen, Conrad Fischer, 2019, Plant Physiology.

USMLE step 3

Conrad Fischer, S. Reichert, 2012 .

4′-Formylbenzo-15-crown-5

E. Weber, B. Ibragimov, Wilhelm Seichter, 2008, Acta crystallographica. Section E, Structure reports online.