R. Bai

发表

Identification of Cysteine 354 of β-Tubulin as Part of the Binding Site for the A Ring of Colchicine (*)

A. Brossi, E. Hamel, R. Bai, 1996, The Journal of Biological Chemistry.

Structure-activity studies with chiral isomers and with segments of the antimitotic marine peptide dolastatin 10.

E. Hamel, G. Pettit, R. Bai, 1990, Biochemical pharmacology.

Identification of the cysteine residue of beta-tubulin alkylated by the antimitotic agent 2,4-dichlorobenzyl thiocyanate, facilitated by separation of the protein subunits of tubulin by hydrophobic column chromatography.

T. Liu, E. Hamel, C. Lin, 1989, Biochemistry.

Differential effects of active isomers, segments, and analogs of dolastatin 10 on ligand interactions with tubulin. Correlation with cytotoxicity.

E. Hamel, R. Luduena, G. Pettit, 1993, Biochemical pharmacology.

Dolastatin 15, a potent antimitotic depsipeptide derived from Dolabella auricularia. Interaction with tubulin and effects of cellular microtubules.

E. Hamel, G. Pettit, R. Bai, 1992, Biochemical pharmacology.

The spongistatins, potently cytotoxic inhibitors of tubulin polymerization, bind in a distinct region of the vinca domain.

Z. Cichacz, E. Hamel, G. Pettit, 1995, Biochemistry.

Dolastatin 10, a powerful cytostatic peptide derived from a marine animal. Inhibition of tubulin polymerization mediated through the vinca alkaloid binding domain.

E. Hamel, G. Pettit, R. Bai, 1990, Biochemical pharmacology.

Mechanism of action of the antimitotic drug 2,4-dichlorobenzyl thiocyanate: alkylation of sulfhydryl group(s) of beta-tubulin.

C. Duanmu, E. Hamel, R. Bai, 1989, Biochimica et biophysica acta.

Characterization of the interaction of cryptophycin 1 with tubulin: binding in the Vinca domain, competitive inhibition of dolastatin 10 binding, and an unusual aggregation reaction.

R. Schwartz, E. Hamel, G. Pettit, 1996, Cancer research.

Spongistatin 1, a highly cytotoxic, sponge-derived, marine natural product that inhibits mitosis, microtubule assembly, and the binding of vinblastine to tubulin.

Z. Cichacz, E. Hamel, G. Pettit, 1993, Molecular pharmacology.

Halichondrin B and homohalichondrin B, marine natural products binding in the vinca domain of tubulin. Discovery of tubulin-based mechanism of action by analysis of differential cytotoxicity data.

K D Paull, K. Paull, E. Hamel, 1991, The Journal of biological chemistry.

Binding of dolastatin 10 to tubulin at a distinct site for peptide antimitotic agents near the exchangeable nucleotide and vinca alkaloid sites.

E. Hamel, G. Pettit, R. Bai, 1990, The Journal of biological chemistry.

Interaction of dolastatin 10 with tubulin: induction of aggregation and binding and dissociation reactions.

E. Hamel, G. Pettit, M. Williams, 1995, Molecular pharmacology.