L. R. Hughes

发表

Non-steroidal antiandrogens. Design of novel compounds based on an infrared study of the dominant conformation and hydrogen-bonding properties of a series of anilide antiandrogens.

P. J. Taylor, A. T. Glen, J. Morris, 1991, Journal of medicinal chemistry.

Receptor binding and biological activity of steroidal and nonsteroidal antiandrogens.

A. T. Glen, A. Wakeling, B. Furr, 1981, Journal of steroid biochemistry.

Phase I trial of ZD1694, a new folate-based thymidylate synthase inhibitor, in patients with solid tumors.

S. Clarke, J. Verweij, I. Judson, 1996, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

Raltitrexed (TomudexTM), a Highly Polyglutamatable Antifolate Thymidylate Synthase Inhibitor

A. Jackman, T. Stephens, F. T. Boyle, 1999 .

Stereoselective synthesis of (.+-.)-indolizidines 167B, 205A, and 207A. Enantioselective synthesis of (-)-indolizidine 209B

A. Holmes, S. F. Williams, A. Smith, 1988 .

The pharmacokinetics of the quinazoline antifolate ICID 1694 in mice and rats

D. Newell, A. Calvert, D. Jodrell, 2004, Cancer Chemotherapy and Pharmacology.

Quinazoline antifolate thymidylate synthase inhibitors: benzoyl ring modifications in the C2-methyl series.

A. Jackman, A. Calvert, J. Oldfield, 1990, Journal of medicinal chemistry.

Thymidylate synthase: a target for anticancer drug design.

D. Newell, A. Jackman, A. Calvert, 1989, Advances in enzyme regulation.

Quinazoline antifolate thymidylate synthase inhibitors: alkyl, substituted alkyl, and aryl substituents in the C2 position.

A. Jackman, A. Calvert, R. C. Smith, 1990, Journal of medicinal chemistry.

Quinazoline antifolate thymidylate synthase inhibitors: heterocyclic benzoyl ring modifications.

A. Hayter, A. Jackman, A. Calvert, 1991, Journal of medicinal chemistry.

Quinazoline antifolate thymidylate synthase inhibitors: replacement of glutamic acid in the C2-methyl series.

A. Jackman, A. Calvert, R. Kimbell, 1995, Journal of medicinal chemistry.

Syntheses and thymidylate synthase inhibitory activity of the poly-gamma-glutamyl conjugates of N-[5-[N-(3,4-dihydro-2-methyl-4-oxoquinazolin-6-ylmethyl)-N-methylamino ]-2-thenoyl]-L-glutamic acid (ICI D1694) and other quinazoline antifolates.

A. Calvert, A. Jackman, L. R. Hughes, 1992, Journal of medicinal chemistry.

Quinazoline antifolate thymidylate synthase inhibitors: bridge modifications and conformationally restricted analogues in the C2-methyl series.

A. Hayter, A. Jackman, A. Calvert, 1991, Journal of medicinal chemistry.

Quinazoline antifolate thymidylate synthase inhibitors: nitrogen, oxygen, sulfur, and chlorine substituents in the C2 position.

A. Hayter, A. Jackman, A. Calvert, 1989, Journal of medicinal chemistry.

Quinazoline Antifolate Thymidylate Synthase Inhibitor That Is a Potent Inhibitor of LI 210 Tumor Cell Growth in Vitro and in Vivo : A New Agent for Clinical Study 1

I. Judson, A. Jackman, A. Calvert, 2006 .

Wittig reactions on unprotected aldohexoses: formation of optically active tetrahydrofurans and tetrahydropyrans

B. J. Wright, A. H. Davidson, L. R. Hughes, 1988 .

Identification of C‐glycopyranosides and C‐glycofuranosides by 13C NMR and 1H NMR. Complete assignment of their spectral data using carbon–proton chemical shift correlation spectroscopy

B. J. Wright, A. H. Davidson, L. R. Hughes, 1988 .

The synthesis of optically active tetrahydropyrans by the addition of a stabilised Witting reagent to pyranose sugars

G. Procter, A. H. Davidson, L. R. Hughes, 1985 .

Total synthesis of the antileukaemic lignan (+/-)-steganacin.

D. Becker, L. R. Hughes, R. A. Raphael, 1977, Journal of the Chemical Society. Perkin transactions 1.

Synthesis of the antileukaemic lignan precursor (±) steganone

L. R. Hughes, R. A. Raphael, 1976 .

BIOMIMETIC POLYENE CYCLIZATIONS. PARTICIPATION OF THE PHENYLACETYLENIC GROUP AS A TERMINATOR AND THE FORMATION OF C/D CIS STEROIDAL PRODUCTS

W. S. Johnson, A. Shenvi, L. R. Hughes, 1979 .

Synthetic studies on ambruticin: Determination of the absolute stereochemistry by a chiral synthesis of the cyclopropane ring

G. Procter, A. H. Davidson, L. R. Hughes, 1981 .

Participation of the allylsilane group as a terminator of biomimetic polyene cyclizations to form steroid-like products

W. S. Johnson, R. Schmid, L. R. Hughes, 1979 .

Nonsteroidal progestins and antiprogestins related to flutamide

J. Woodburn, B. Furr, M. Dukes, 2000, Steroids.

Quinoline antifolate thymidylate synthase inhibitors: variation of the C2- and C4-substituents.

A. Barker, A. Jackman, P. Warner, 1992, Journal of medicinal chemistry.

Technical Report Abstracts

J. Bensted, L. R. Hughes, S. Clinton, 1993, Environmental Health Perspectives.

Thymidylate Synthase Inhibition of Modified Quinazoline Antifolates

A. Barker, A. Jackman, P. Warner, 1992 .

The renal effects of N10-propargyl-5,8-dideazafolic acid (CB3717) and a non-nephrotoxic analogue ICI D1694, in mice.

D. Newell, J. Bensted, A. Calvert, 1991, British Journal of Cancer.

ICI D1694, a quinazoline antifolate thymidylate synthase inhibitor that is a potent inhibitor of L1210 tumor cell growth in vitro and in vivo: a new agent for clinical study.

I. Judson, A. Jackman, A. Calvert, 1991, Cancer research.

Additions and Corrections - Biomimetic Polyene Cyclizations. A Comparison of the Phenylacetylenic and Styryl Terminators in Influencing the Stereoselectivity of Processes Leading to Steroidal Products

L. R. Hughes, J. Carlson, W. Johnson, 1979 .

Quinazoline-based thymidylate synthase inhibitors: relationship between structural modifications and polyglutamation.

L. Brunton, A. Jackman, V. Bavetsias, 1995, Anti-cancer drug design.